Search Results - "Wielinga, P. Y"

Toll-like receptor 2-deficient mice are protected from insulin resistance and beta cell dysfunction induced by a high-fat diet by Ehses, J. A, Meier, D. T, Wueest, S, Rytka, J, Boller, S, Wielinga, P. Y, Schraenen, A, Lemaire, K, Debray, S, Van Lommel, L, Pospisilik, J. A, Tschopp, O, Schultze, S. M, Malipiero, U, Esterbauer, H, Ellingsgaard, H, Rütti, S, Schuit, F. C, Lutz, T. A, Böni-Schnetzler, M, Konrad, D, Donath, Marc Y

“…Aims/hypothesis Inflammation contributes to both insulin resistance and pancreatic beta cell failure in human type 2 diabetes. Toll-like receptors (TLRs) are…”
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Metabolic stress-induced inflammation plays a major role in the development of osteoarthritis in mice by Gierman, L. M., van der Ham, F., Koudijs, A., Wielinga, P. Y., Kleemann, R., Kooistra, T., Stoop, R., Kloppenburg, M., van Osch, G. J. V. M., Stojanovic-Susulic, V., Huizinga, T. W., Zuurmond, A.-M.

“…Objective Obesity is associated with systemic inflammation and is a risk factor for osteoarthritis (OA) development. We undertook this study to test the…”
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Modulation of the satiating effect of amylin by central ghrelin, leptin and insulin by Osto, M, Wielinga, P.Y, Alder, B, Walser, N, Lutz, T.A

“…Abstract Amylin is a pancreatic hormone that is considered to be a satiating signal acting on neurons of the area postrema (AP) in the hindbrain. The adiposity…”
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Surgical removal of inflamed epididymal white adipose tissue attenuates the development of non-alcoholic steatohepatitis in obesity by Mulder, P, Morrison, M C, Wielinga, P Y, van Duyvenvoorde, W, Kooistra, T, Kleemann, R

“…Background: Non-alcoholic fatty liver disease (NAFLD) is strongly associated with abdominal obesity. Growing evidence suggests that inflammation in specific…”
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Butyrate restores HFD-induced adaptations in brain function and metabolism in mid-adult obese mice by Arnoldussen, I A C, Wiesmann, M, Pelgrim, C E, Wielemaker, E M, van Duyvenvoorde, W, Amaral-Santos, P L, Verschuren, L, Keijser, B J F, Heerschap, A, Kleemann, R, Wielinga, P Y, Kiliaan, A J

“…Objective: Midlife obesity affects cognition and increases risk of developing dementia. Recent data suggest that intake of the short chain fatty acid butyrate…”
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Intervention with a caspase-1 inhibitor reduces obesity-associated hyperinsulinemia, non-alcoholic steatohepatitis and hepatic fibrosis in LDLR−/−.Leiden mice by Morrison, M C, Mulder, P, Salic, K, Verheij, J, Liang, W, van Duyvenvoorde, W, Menke, A, Kooistra, T, Kleemann, R, Wielinga, P Y

“…Background/Objectives: Non-alcoholic steatohepatitis (NASH) is a serious liver condition, closely associated with obesity and insulin resistance. Recent…”
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Lipid ratios representing SCD1, FADS1, and FADS2 activities as candidate biomarkers of early growth and adiposity by Olga, L., van Diepen, J.A., Bobeldijk-Pastorova, I., Gross, G., Prentice, P.M., Snowden, S.G., Furse, S., Kooistra, T., Hughes, I.A., Schoemaker, M.H., van Tol, E.A.F., van Duyvenvoorde, W., Wielinga, P.Y., Ong, K.K., Dunger, D.B., Kleemann, R., Koulman, A.

“…Altered lipid metabolism in early life has been associated with subsequent weight gain and predicting this could aid in obesity prevention and risk management…”
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The passive coping Roman Low Avoidance rat, a non-obese rat model for insulin resistance by Boersma, G.J, Scheurink, A.J.W, Wielinga, P.Y, Steimer, T.J, Benthem, L

“…Abstract The aim of the study was develop to an animal model that links coping style to insulin resistance. We hypothesized that the psychogenetically selected…”
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Neonatal capsaicin causes compensatory adjustments to energy homeostasis in rats by van de Wall, E.H.E.M., Wielinga, P.Y., Strubbe, J.H., van Dijk, G.

“…Several mechanisms involved in ingestive behavior and neuroendocrine activity rely on vagal afferent neuronal signaling. Seemingly contradictory to this idea…”
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Chronic central infusion of amylin lowers body weight gain independent of initial body weight in chow fed rats but not in rats after 3 weeks of Ensure super(()R) feeding by Wielinga, P Y, Muff, S, Munz, M, Woods, S C, Lutz, T A

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In-vitro and in-vlvo antagonistic action of an anti-amylln Spiegelmer by Bilik, K U, Ergven, E, Klussmann, S, Jarosch, F, Wielinga, P Y, Lutz, T A, Riediger, T

“…The anorectic and dipsogenic effects of the pancreatic hormone amylin are mediated by the area postrema and the subfornical organ. We tested the effectiveness…”
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Central modulation of the feeding response to amylin by leptin and insulin by Osto, M., Wielinga, P.Y., Alder, B., Walser, N., Lutz, T.A.

“…Amylin is a pancreatic hormone, which is considered a satiating signal acting on neurons of the area postrema (AP). The orexigenic hormone ghrelin and the…”
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Neonatal capsaicin causes compensatory adjustments to energy homeostasis in rats: Making sense of food by VAN DE WALL, E. H. E. M, WIELINGA, P. Y, STRUBBE, J. H, VAN DIJK, G

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Hydroxycitric acid delays intestinal glucose absorption in rats by Wielinga, Peter Y, Wachters-Hagedoorn, Renate E, Bouter, Brenda, van Dijk, Theo H, Stellaard, Frans, Nieuwenhuizen, Arie G, Verkade, Henkjan J, Scheurink, Anton J W

“…In this study, we investigated in rats if hydroxycitric acid (HCA) reduces the postprandial glucose response by affecting gastric emptying or intestinal…”
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