Search Results - "Wieland, Heike"

Osteoarthritis - an untreatable disease? by Wieland, Heike A, Michaelis, Martin, Kirschbaum, Bernhard J, Rudolphi, Karl A

“…Osteoarthritis is a painful and disabling disease that affects millions of patients. Its aetiology is largely unknown, but is most likely multi-factorial…”
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In Vivo Imaging of MMP‐13 Activity Using a Specific Polymer‐FRET Peptide Conjugate Detects Early Osteoarthritis and Inhibitor Efficacy by Duro‐Castano, Aroa, Lim, Ngee Han, Tranchant, Isabelle, Amoura, Mehdi, Beau, Fabrice, Wieland, Heike, Kingler, Otmar, Herrmann, Matthias, Nazaré, Marc, Plettenburg, Oliver, Dive, Vincent, Vicent, María J., Nagase, Hideaki

“…Imaging early molecular changes in osteoarthritic (OA) joints is instrumental for the development of disease‐modifying drugs. To this end, a fluorescent…”
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Biodynamer Nano-Complexes and -Emulsions for Peptide and Protein Drug Delivery by Liu, Yun, Hamm, Timo, Eichinger, Thomas Ralf, Kamm, Walter, Wieland, Heike Andrea, Loretz, Brigitta, Hirsch, Anna K H, Lee, Sangeun, Lehr, Claus-Michael

“…Therapeutic proteins and peptides offer great advantages compared to traditional synthetic molecular drugs. However, stable protein loading and precise control…”
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BIIE0246: A selective and high affinity neuropeptide Y Y2 receptor antagonist by Doods, Henri, Gaida, Wolfram, Wieland, Heike A, Dollinger, Horst, Schnorrenberg, Gerd, Esser, Franz, Engel, Wolfhard, Eberlein, Wolfgang, Rudolf, Klaus

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Effects of the neuropeptide Y Y2 receptor antagonist BIIE0246 on presynaptic inhibition by neuropeptide Y in rat hippocampal slices by WEISER, Thomas, WIELAND, Heike A, DOODS, Henri N

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Four amino acid exchanges convert a diazepam-insensitive, inverse agonist-preferring GABAA receptor into a diazepam-preferring GABAA receptor by Wieland, Heike A, Lueddens, Hartmut

“…Benzodiazepines (BZ) exert their effects through GABAA receptors, which belong to the superfamily of ligand-gated ion channels. Coexpression of recombinant…”
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The first highly potent and selective non-peptide neuropeptide Y Y1 receptor antagonist: BIBP3226 by Rudolf, K, Eberlein, W, Engel, W, Wieland, H A, Willim, K D, Entzeroth, M, Wienen, W, Beck-Sickinger, A G, Doods, H N

“…The design and subsequent in vitro and in vivo biological characterisation of the first potent and selective non-peptide neuropeptide Y Y1 receptor antagonist,…”
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Ala31-Aib32:  Identification of the Key Motif for High Affinity and Selectivity of Neuropeptide Y at the Y5-Receptor by Cabrele, Chiara, Wieland, Heike A, Koglin, Norman, Stidsen, Carsten, Beck-Sickinger, Annette G

“…The turn-inducing sequence Ala-Aib introduced into positions 31 and 32 of neuropeptide Y (NPY) and its analogues has been identified as the key structure for…”
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Distinct pharmacological properties of second generation HDAC inhibitors with the benzamide or hydroxamate head group by Beckers, Thomas, Burkhardt, Carmen, Wieland, Heike, Gimmnich, Petra, Ciossek, Thomas, Maier, Thomas, Sanders, Karl

“…Advanced second generation inhibitors of histone deacetylases (HDAC) are currently used in clinical development. This study aimed at comparing the…”
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Characterisation of Neuropeptide Y Receptor Subtypes by Synthetic NPY Analogues and by Anti-receptor Antibodies by Eckard, Christophe P., Cabrele, Chiara, Wieland, Heike A., Beck-Sickinger, Annette G.

“…Neuropeptide Y (NPY), a 36-mer neuromodulator, binds to the receptors Y1, Y2, Y4 and Y5 with nanomolar affinity. They all belong to the rhodopsin-like…”
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Validation of a diffusion chamber as in vitro system for the analysis of compound diffusibility through cartilage tissue by Kreiselmeier, Alexander, Ulmer, Wolfgang, Stöve, Johannes, Wieland, Heike A., Gerwin, Nicole, Bartnik, Eckart, Schudok, Manfred, Heute, Steffen, Breitenfelder, Michael, Scharf, Hanns-Peter, Schwarz, Markus L.R.

“…The validation of a diffusion chamber comprising a donor and a receptor side separated by a cartilage membrane was undertaken according to the basic principles…”
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Characterization of the NPGP receptor and identification of a novel short mRNA isoform in human hypothalamus by Laemmle, Baerbel, Schindler, Marcus, Beilmann, Mario, Hamilton, Bradford S, Doods, Henri N, Wieland, Heike A

“…Recently, an orphan G protein coupled receptor (GPCR) termed NPGPR was described. A shorter variant of this receptor lacking exon 1 was shown to have…”
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Modified, cyclic dodecapeptide analog of neuropeptide Y is the smallest full agonist at the human Y2 receptor by Rist, Beate, Zerbe, Oliver, Ingenhoven, Nikolaus, Scapozza, Leonardo, Peers, Chris, Vaughan, Peter F.T, McDonald, Ruth L, Wieland, Heike A, Beck-Sickinger, Annette G

“…In order to stabilize the C‐terminal dodecapeptide of neuropeptide Y (NPY) we replaced Leu28 and Thr32 by Lys and Glu, respectively, and subsequently linked…”
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The SK‐N‐MC cell line expresses an orexin binding site different from recombinant orexin 1‐type receptor by Wieland, Heike A., Söll, Richard M., Doods, Henri N., Stenkamp, Dirk, Hurnaus, Rudolf, Lämmle, Bärbel, Beck‐Sickinger, Annette G.

“…Orexin A and B (also known as hypocretins), two recently discovered neuropeptides, play an important role in food intake, sleep/wake cycle and neuroendocrine…”
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BIBP 3226, the first selective neuropeptide Y1 receptor antagonist: A review of its pharmacological properties by Doods, Henri N., Wieland, Heike A., Engel, Wolfhard, Eberlein, Wolfgang, Willim, Klaus-Dieter, Entzeroth, Michael, Wienen, Wolfgang, Rudolf, Klaus

“…Based on the assumption that the pharmacophoric groups interacting with the Y1 receptor are located in the C-terminal part of neuropeptide Y, low molecular…”
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A homogeneous cellular histone deacetylase assay suitable for compound profiling and robotic screening by Ciossek, Thomas, Julius, Heiko, Wieland, Heike, Maier, Thomas, Beckers, Thomas

“…Most cellular assays that quantify the efficacy of histone deacetylase (HDAC) inhibitors measure hyperacetylation of core histone proteins H3 and H4. Here we…”
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Trithiocarbonates as a Novel Class of HDAC Inhibitors: SAR Studies, Isoenzyme Selectivity, and Pharmacological Profiles by Dehmel, Florian, Weinbrenner, Steffen, Julius, Heiko, Ciossek, Thomas, Maier, Thomas, Stengel, Thomas, Fettis, Kamal, Burkhardt, Carmen, Wieland, Heike, Beckers, Thomas

“…Inhibitors of histone deacetylases (HDAC) are currently developed for the treatment of cancer. These include compounds with a sulfur containing head group like…”
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Divalent cations influencing neuropeptide Y receptor subtype binding in rat hippocampus and cortex membranes as well as in recombinant cells by Wieland, Heike A, Willim, K, Doods, Henri N

“…At least six types of neuropeptide Y (NPY) receptors (Y1–Y6) have been pharmacologically distinguished of which only the Y1, Y2, Y4 and Y5 subtypes have been…”
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CENTRAL CATHEPSIN B INHIBITION BY CA074 DOES NOT ALTER THE LEVELS OF NEUROTOXIC Aβ SPECIES IN THE BRAIN OF HAPP-LON MICE by Heym, Roland Gerhard, Awwad, Khader, Giaisi, Simone, Weiss, Sabine, Wieland, Heike, Schulz, Michael, Jantos, Katja, Kling, Andreas, Fang, Zhizhou, Louise van der Kam, Elizabeth, Hornberger, Wilfried, Buck, Kerstin

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P3‐039: Central Cathepsin B Inhibition by CA074 Does Not Alter the Levels of Neurotoxic Aβ Species in the Brain of Happ‐Lon Mice by Heym, Roland Gerhard, Awwad, Khader, Giaisi, Simone, Weiss, Sabine, Wieland, Heike, Schulz, Michael, Jantos, Katja, Kling, Andreas, Fang, Zhizhou, Louise van der Kam, Elizabeth, Hornberger, Wilfried, Buck, Kerstin

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