Search Results - "Wiegand, Frank"

Treatment patterns of patients diagnosed with major depressive disorder and suicidal ideation or attempt: a U.S. population-based study utilizing real-world data by Kern, David M, Cepeda, M Soledad, Wiegand, Frank

“…There is a knowledge gap regarding the treatment patterns of patients with major depressive disorder (MDD) who experience suicidal ideation or a suicide…”
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Estimating Prevalence and Healthcare Utilization for Treatment-Resistant Depression in Japan: A Retrospective Claims Database Study by Mahlich, Jörg, Tsukazawa, Sunny, Wiegand, Frank

“…Background Major depressive disorders (MDDs) including treatment-resistant depression (TRD) are common disabling conditions, but data on their epidemiology in…”
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Serial Analysis of Gene Expression Identifies Metallothionein-II as Major Neuroprotective Gene in Mouse Focal Cerebral Ischemia by Trendelenburg, George, Prass, Konstantin, Priller, Josef, Kapinya, Krisztian, Polley, Andreas, Muselmann, Claudia, Ruscher, Karsten, Kannbley, Ute, Schmitt, Armin O, Castell, Stefanie, Wiegand, Frank, Meisel, Andreas, Rosenthal, Andre, Dirnagl, Ulrich

“…We applied serial analysis of gene expression (SAGE) to study differentially expressed genes in mouse brain 14 hr after the induction of focal cerebral…”
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The DTA “Base Format”: A TEI Subset for the Compilation of a Large Reference Corpus of Printed Text from Multiple Sources by Haaf, Susanne, Geyken, Alexander, Wiegand, Frank

“…In this article we describe the DTA “Base Format” (DTABf), a strict subset of the TEI P5 tag set. The purpose of the DTABf is to provide a balance between…”
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Measuring the Correctness of Double-Keying: Error Classification and Quality Control in a Large Corpus of TEI-Annotated Historical Text by Haaf, Susanne, Wiegand, Frank, Geyken, Alexander

“…Among mass digitization methods, double-keying is considered to be the one with the lowest error rate. This method requires two independent transcriptions of a…”
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ZK200775: A Phosphonate Quinoxalinedione AMPA Antagonist for Neuroprotection in Stroke and Trauma by Turski, Lechoslaw, Huth, Andreas, Sheardown, Malcolm, McDonald, Fiona, Neuhaus, Roland, Schneider, Herbert H., Dirnagl, Ulrich, Wiegand, Frank, Jacobsen, Poul, Ottow, Eckhard

“…Stroke and head trauma are worldwide public health problems and leading causes of death and disability in humans, yet, no adequate neuroprotective treatment is…”
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Induction of tolerance in rat cortical neurons: hypoxic preconditioning by Bruer, Ulrike, Weih, Markus K, Isaev, Nikolaj K, Meisel, Andreas, Ruscher, Karsten, Bergk, Alexandra, Trendelenburg, George, Wiegand, Frank, Victorov, Ilya V, Dirnagl, Ulrich

“…Sublethal ischemia leads to increased tolerance against subsequent prolonged cerebral ischemia in vivo. In the present study we modeled preconditioning…”
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105. Intranasal 5-MeO-DMT: Safety, PK and Effect on Altered States of Consciousness in Healthy Volunteers by Rucker, James, Seynaeve, Mathieu, Young, Allan H., Roberts, Claire, Suttle, Ben, Yamamoto, Takahiro, Ermakova, Anna O., Dunbar, Fiona, Wiegand, Frank

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Physicians in the pharmaceutical industry: their roles, motivations, and perspectives by Sweiti, Hussein, Wiegand, Frank, Bug, Christoph, Vogel, Martin, Lavie, Frederic, Winiger-Candolfi, Ivo, Schuier, Maximilian

“…•Clinicians may often be unaware of career opportunities outside of patient care.•Structures of pharmaceutical companies may vary based on therapeutic focus &…”
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Phase 1, placebo-controlled, single ascending dose trial to evaluate the safety, pharmacokinetics and effect on altered states of consciousness of intranasal BPL-003 (5-methoxy-N,N-dimethyltryptamine benzoate) in healthy participants by Rucker, James Jonathan, Roberts, Claire, Seynaeve, Mathieu, Young, Allan H., Suttle, Ben, Yamamoto, Takahiro, Ermakova, Anna O., Dunbar, Fiona, Wiegand, Frank

“…Aims: To investigate the safety, tolerability, pharmacokinetics (PK) and pharmacodynamics (PD) of BPL-003, a novel intranasal benzoate salt formulation of…”
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Managing Esketamine Treatment Frequency Toward Successful Outcomes: Analysis of Phase 3 Data by Nijs, Michel, Wajs, Ewa, Aluisio, Leah, Turkoz, Ibrahim, Daly, Ella, Janik, Adam, Borentain, Stephane, Singh, Jaskaran B, DiBernardo, Allitia, Wiegand, Frank

“…Esketamine nasal spray was recently approved for treatment-resistant depression. The current analysis evaluated the impact of symptom-based treatment frequency…”
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Psychedelics for Medicinal Use: How Will This Alter the Collective Laboratory Consciousness? by Cotten, Steven W, Strathmann, Frederick G, Barrett, Frederick S, Labay, Laura, Mullally, James, Sherwood, Alexander M, Wiegand, Frank

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Intravenous Esketamine in Adult Treatment-Resistant Depression: A Double-Blind, Double-Randomization, Placebo-Controlled Study by Singh, Jaskaran B, Fedgchin, Maggie, Daly, Ella, Xi, Liwen, Melman, Caroline, De Bruecker, Geert, Tadic, Andre, Sienaert, Pascal, Wiegand, Frank, Manji, Husseini, Drevets, Wayne C, Van Nueten, Luc

“…Abstract Background The purpose of this study was to assess the efficacy and safety and to explore the dose response of esketamine intravenous (IV) infusion in…”
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Topiramate for Treating Alcohol Dependence: A Randomized Controlled Trial by Johnson, Bankole A, Rosenthal, Norman, Capece, Julie A, Wiegand, Frank, Mao, Lian, Beyers, Karen, McKay, Amy, Ait-Daoud, Nassima, Anton, Raymond F, Ciraulo, Domenic A, Kranzler, Henry R, Mann, Karl, O’Malley, Stephanie S, Swift, Robert M, Topiramate for Alcoholism Advisory Board and the Topiramate for Alcoholism Study Group, for the

“…CONTEXT Hypothetically, topiramate can improve drinking outcomes among alcohol-dependent individuals by reducing alcohol's reinforcing effects through…”
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Effect of Sleep Disturbance on Efficacy of Esketamine in Treatment-Resistant Depression: Findings from Randomized Controlled Trials by Borentain, Stephane, Williamson, David, Turkoz, Ibrahim, Popova, Vanina, McCall, William V, Mathews, Maju, Wiegand, Frank

“…To evaluate the relationship of sleep disturbance to the antidepressant effects of esketamine. Two double-blind, 4-week studies randomized adults with…”
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Efficacy, tolerability, and safety of rapid initiation of topiramate versus phenytoin in patients with new‐onset epilepsy: A randomized double‐blind clinical trial by Ramsay, Eugene, Faught, Edward, Krumholz, Allan, Naritoku, Dean, Privitera, Michael, Schwarzman, Lesley, Mao, Lian, Wiegand, Frank, Hulihan, Joseph

“…Summary Purpose:  To evaluate topiramate (TPM) and phenytoin (PHT) monotherapy following rapid oral initiation in new‐onset epilepsy. Methods:  Randomized,…”
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Placebo Response Changes Depending on the Neuropathic Pain Syndrome: Results of a Systematic Review and Meta-Analysis by Cepeda, M. Soledad, Berlin, Jesse A., Gao, C. Yuying, Wiegand, Frank, Wada, D. Russell

“…Objective.  To compare placebo responses in neuropathic pain syndromes. Design.  Systematic literature review and meta‐analysis. Setting and Patients. …”
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Population pharmacodynamic modeling of various extended-release formulations of methylphenidate in children with attention deficit hyperactivity disorder via meta-analysis by Kimko, Holly, Gibiansky, Ekaterina, Gibiansky, Leonid, Starr, H. Lynn, Berwaerts, Joris, Massarella, Joseph, Wiegand, Frank

“…Placebo and pharmacodynamic (PD) models were developed which link temporal measures of efficacy in children with attention deficit hyperactivity disorder…”
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Carisbamate in essential tremor: Brief report of a proof of concept study by Elble, Rodger J., Biondi, David M., Ascher, Steve, Wiegand, Frank, Hulihan, Joseph

“…The efficacy and safety of carisbamate, an investigational neuromodulator currently in development for epilepsy, were examined in a multicenter, randomized,…”
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A multicenter, outpatient, open-label study to evaluate the dosing, effectiveness, and safety of topiramate as monotherapy in the treatment of epilepsy in clinical practice by Sankar, Raman, Ramsay, Eugene, McKay, Amy, Hulihan, Joseph, Wiegand, Frank

“…Abstract This 24-week, multicenter, open-label trial was designed to evaluate the dosing, effectiveness, and safety of topiramate monotherapy for epilepsy and…”
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