Search Results - "Wiedmann, Felix"

Two-Pore-Domain Potassium (K 2P -) Channels: Cardiac Expression Patterns and Disease-Specific Remodelling Processes by Wiedmann, Felix, Frey, Norbert, Schmidt, Constanze

“…Two-pore-domain potassium (K -) channels conduct outward K currents that maintain the resting membrane potential and modulate action potential repolarization…”
Get full text

Small Conductance Ca2 +-Activated K+ (SK) Channel mRNA Expression in Human Atrial and Ventricular Tissue: Comparison Between Donor, Atrial Fibrillation and Heart Failure Tissue by Darkow, Elisa, Nguyen, Thong T., Stolina, Marina, Kari, Fabian A., Schmidt, Constanze, Wiedmann, Felix, Baczkó, István, Kohl, Peter, Rajamani, Sridharan, Ravens, Ursula, Peyronnet, Rémi

“…In search of more efficacious and safe pharmacological treatments for atrial fibrillation (AF), atria-selective antiarrhythmic agents have been promoted that…”
Get full text

Antiarrhythmic Properties of Ranolazine: Inhibition of Atrial Fibrillation Associated TASK-1 Potassium Channels by Ratte, Antonius, Wiedmann, Felix, Kraft, Manuel, Katus, Hugo A, Schmidt, Constanze

“…Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia and one of the major causes of cardiovascular morbidity and mortality. Despite good…”
Get full text

The Experimental TASK-1 Potassium Channel Inhibitor A293 Can Be Employed for Rhythm Control of Persistent Atrial Fibrillation in a Translational Large Animal Model by Wiedmann, Felix, Beyersdorf, Christoph, Zhou, Xiao-Bo, Kraft, Manuel, Foerster, Kathrin I, El-Battrawy, Ibrahim, Lang, Siegfried, Borggrefe, Martin, Haefeli, Walter E, Frey, Norbert, Schmidt, Constanze

“…Upregulation of the two-pore-domain potassium channel TASK-1 (hK 3.1) was recently described in patients suffering from atrial fibrillation (AF) and resulted…”
Get full text

MicroRNAs Regulate TASK-1 and Are Linked to Myocardial Dilatation in Atrial Fibrillation by Wiedmann, Felix, Kraft, Manuel, Kallenberger, Stefan, Büscher, Antonius, Paasche, Amelie, Blochberger, Pablo L, Seeger, Timon, Jávorszky, Natasa, Warnecke, Gregor, Arif, Rawa, Kremer, Jamila, Karck, Matthias, Frey, Norbert, Schmidt, Constanze

“…Background Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia. However, underlying molecular mechanisms are insufficiently understood…”
Get full text

A porcine large animal model of radiofrequency ablation-induced left bundle branch block by Wiedmann, Felix, Jamros, Max, Herlt, Valerie, Paasche, Amelie, Kraft, Manuel, Beck, Moritz, Prüser, Merten, Erkal, Atilla, Harder, Maren, Zaradzki, Marcin, Soethoff, Jasmin, Karck, Matthias, Frey, Norbert, Schmidt, Constanze

“…Electrocardiographic (ECG) features of left bundle branch (LBB) block (LBBB) can be observed in up to 20%-30% of patients suffering from heart failure with…”
Get full text

Atrial fibrillation and heart failure-associated remodeling of two-pore-domain potassium (K2P) channels in murine disease models: focus on TASK-1 by Wiedmann, Felix, Schulte, Jan S., Gomes, Bruna, Zafeiriou, Maria-Patapia, Ratte, Antonius, Rathjens, Franziska, Fehrmann, Edda, Scholz, Beatrix, Voigt, Niels, Müller, Frank Ulrich, Thomas, Dierk, Katus, Hugo A., Schmidt, Constanze

“…Understanding molecular mechanisms involved in atrial tissue remodeling and arrhythmogenesis in atrial fibrillation (AF) is essential for developing specific…”
Get full text

Inhibition of cardiac two-pore-domain K+ (K2P) channels--an emerging antiarrhythmic concept by Schmidt, Constanze, Wiedmann, Felix, Schweizer, Patrick A, Katus, Hugo A, Thomas, Dierk

“…Effective and safe pharmacological management of cardiac arrhythmia still constitutes a major clinical challenge. Outward potassium currents mediated by…”
Get full text

Pharmacologic TWIK-Related Acid-Sensitive K+ Channel (TASK-1) Potassium Channel Inhibitor A293 Facilitates Acute Cardioversion of Paroxysmal Atrial Fibrillation in a Porcine Large Animal Model by Wiedmann, Felix, Beyersdorf, Christoph, Zhou, Xiaobo, Büscher, Antonius, Kraft, Manuel, Nietfeld, Jendrik, Walz, Teo Puig, Unger, Laura A, Loewe, Axel, Schmack, Bastian, Ruhparwar, Arjang, Karck, Matthias, Thomas, Dierk, Borggrefe, Martin, Seemann, Gunnar, Katus, Hugo A, Schmidt, Constanze

“…Background The tandem of P domains in a weak inward rectifying K+ channel (TWIK)-related acid-sensitive K channel (TASK-1; hK 3.1) two-pore-domain potassium…”
Get full text

Current Drug Treatment Strategies for Atrial Fibrillation and TASK-1 Inhibition as an Emerging Novel Therapy Option by Kraft, Manuel, Büscher, Antonius, Wiedmann, Felix, L'hoste, Yannick, Haefeli, Walter E, Frey, Norbert, Katus, Hugo A, Schmidt, Constanze

“…Atrial fibrillation (AF) is the most common sustained arrhythmia with a prevalence of up to 4% and an upwards trend due to demographic changes. It is…”
Get full text

Treatment of a Paroxysmal Atrioventricular Block by Implantation of a Bipolar, Single-Chamber Cardiac Pacemaker in a Donkey by Heun, Frederik, Niebuhr, Tobias, Gutierrez Bautista, Alvaro, Wiedmann, Felix, Verhaar, Nicole, Kästner, Sabine, Feige, Karsten, Schmidt, Constanze

“…Case Summary: A two-year-old donkey presented with recurrent syncope. Electrocardiography revealed periods without any atrioventricular conduction and without…”
Get full text

Axial Tubule Junctions Activate Atrial Ca2+ Release Across Species by Brandenburg, Sören, Pawlowitz, Jan, Fakuade, Funsho E., Kownatzki-Danger, Daniel, Kohl, Tobias, Mitronova, Gyuzel Y., Scardigli, Marina, Neef, Jakob, Schmidt, Constanze, Wiedmann, Felix, Pavone, Francesco S., Sacconi, Leonardo, Kutschka, Ingo, Sossalla, Samuel, Moser, Tobias, Voigt, Niels, Lehnart, Stephan E.

“…Rationale: Recently, abundant axial tubule (AT) membrane structures were identified deep inside atrial myocytes (AMs). Upon excitation, ATs rapidly activate…”
Get full text

N-Glycosylation of TREK-1/hK2P2.1 Two-Pore-Domain Potassium (K2P) Channels by Wiedmann, Felix, Schlund, Daniel, Faustino, Francisco, Kraft, Manuel, Ratte, Antonius, Thomas, Dierk, Katus, Hugo A., Schmidt, Constanze

“…Mechanosensitive hTREK-1 two-pore-domain potassium (hK2P2.1) channels give rise to background currents that control cellular excitability. Recently, TREK-1…”
Get full text

Identification of the A293 (AVE1231) Binding Site in the Cardiac Two-Pore-Domain Potassium Channel TASK-1: a Common Low Affinity Antiarrhythmic Drug Binding Site by Wiedmann, Felix, Kiper, Aytug K, Bedoya, Mauricio, Ratte, Antonius, Rinné, Susanne, Kraft, Manuel, Waibel, Maximilian, Anad, Priya, Wenzel, Wolfgang, González, Wendy, Katus, Hugo A, Decher, Niels, Schmidt, Constanze

“…The two-pore-domain potassium channel TASK-1 regulates atrial action potential duration. Due to the atrium-specific expression of TASK-1 in the human heart and…”
Get full text

A Simple, Non-Invasive Score to Predict Paroxysmal Atrial Fibrillation by Kallenberger, Stefan M, Schmid, Christian, Wiedmann, Felix, Mereles, Derliz, Katus, Hugo A, Thomas, Dierk, Schmidt, Constanze

“…Paroxysmal atrial fibrillation (pAF) is a major risk factor for stroke but remains often unobserved. To predict the presence of pAF, we developed model scores…”
Get full text

Simultaneous Quantification and Pharmacokinetic Characterization of Doxapram and 2-Ketodoxapram in Porcine Plasma and Brain Tissue by Kraft, Manuel, Foerster, Kathrin I, Wiedmann, Felix, Sauter, Max, Paasche, Amelie, Blochberger, Pablo L, Yesilgöz, Baran, L'hoste, Yannick, Frey, Norbert, Haefeli, Walter E, Burhenne, Jürgen, Schmidt, Constanze

“…Atrial fibrillation (AF) is an arrhythmia associated with an increased stroke risk and mortality rate. Current treatment options leave unmet needs in AF…”
Get full text

Novel drug therapies for atrial fibrillation by Wiedmann, Felix, Schmidt, Constanze

“…Atrial fibrillation is the most common sustained arrhythmia and imposes a substantial burden on patients and health-care providers. Clinical evidence suggests…”
Get full text

Comment on: ‘Physiological and pathophysiological roles of the KCNK3 potassium channel in the pulmonary circulation and the heart’ by Saint‐Martin Willer et al by Prüser, Merten, Wiedmann, Felix, Schmidt, Constanze

Get full text

Inhibition of the potassium channel TASK-1 in human atria to reduce arrhythmogenesis by Hegner, Philipp, Schuh, Manuel, Wiedmann, Felix, Camboni, Daniele, Schmid, Christof, Maier, Lars Siegfried, Schmidt, Constanze, Wagner, Stefan

Get full text

Mechanosensitive TREK-1 two-pore-domain potassium (K2P) channels in the cardiovascular system by Wiedmann, Felix, Rinné, Susanne, Donner, Birgit, Decher, Niels, Katus, Hugo A., Schmidt, Constanze

“…TWIK-related K+ channel (TREK-1) two-pore-domain potassium (K2P) channels mediate background potassium currents and regulate cellular excitability in many…”
Get full text