Search Results - "Wiederrecht, Gregory J."

Immunopharmacology of rapamycin by Abraham, R T, Wiederrecht, G J

“…The potent immunosuppressive drugs FK506 and rapamycin interfere with signal transduction pathways required for T cell activation and growth. The distinct…”
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A Novel FK506 Binding Protein Can Mediate the Immunosuppressive Effects of FK506 and Is Associated with the Cardiac Ryanodine Receptor (∗) by Lam, Elsa, Martin, Mary M., Timerman, Anthony P., Sabers, Candace, Fleischer, Sidney, Lukas, Thomas, Abraham, Robert T., O'Keefe, Stephen J., O'Neill, Edward A., Wiederrecht, Gregory J.

“…FK506, an immunosuppressant that prolongs allograft survival, is a co-drug with its intracellular receptor, FKBP12. The FKBP12•FK506 complex inhibits…”
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Partnership between small biotech and big pharma by Wiederrecht, Gregory J, Hill, Raymond G, Beer, Margaret S

“…The process involved in the identification and development of novel breakthrough medicines at big pharma has recently undergone significant changes, in part…”
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Tissue Distribution and Abundance of Human FKBP51, an FK506-Binding Protein That Can Mediate Calcineurin Inhibition by Baughman, Gail, Wiederrecht, Gregory J., Chang, Fon, Martin, Mary M., Bourgeois, Suzanne

“…We previously described the isolation of an FK506-binding protein, FKBP51, that is predominantly expressed in murine T cells and is capable of mediating…”
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FKBP51, a novel T-cell-specific immunophilin capable of calcineurin inhibition by Baughman, Gail, Wiederrecht, Gregory J., Campbell, N. Faith, Martin, Mary M., Bourgeois, Suzanne

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Cryoelectron microscopy resolves FK506-binding protein sites on the skeletal muscle ryanodine receptor by Wagenknecht, T., Grassucci, R., Berkowitz, J., Wiederrecht, G.J., Xin, H.B., Fleischer, S.

“…A 12-kDa immunophilin (FKBP12) is an integral component of the skeletal muscle ryanodine receptor (RyR). The RyR is a hetero-oligomeric complex with structural…”
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IMMUNOPHARMACOLOGY OF RAPAMYCIN 1 by Abraham, Robert T, Wiederrecht, Gregory J

“…The potent immunosuppressive drugs FK506 and rapamycin interfere with signal transduction pathways required for T cell activation and growth. The distinct…”
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Inhibition of calcineurin by a novel FK-506-binding protein by SEWELL, T. J, LAM, E, SIGAL, N. H, WIEDERRECHT, G. J, MARTIN, M. M, LESZYK, J, WEIDNER, J, CALAYCAY, J, GRIFFIN, P, WILLIAMS, H, HUNG, S, CRYAN, J

“…FK-506, a potent immunosuppressive drug, acts during the commitment phase of T-lymphocyte activation to block a subset of calcium-associated events necessary…”
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A tacrolimus-related immunosuppressant with biochemical properties distinct from those of tacrolimus by PETERSON, L. B, CRYAN, J. G, WYVRATT, M, SIGAL, N. H, WILLIAMSON, A. R, WIEDERRECHT, G. J, ROSA, R, MARTIN, M. M, WILUSZ, M. B, SINCLAIR, P. J, WONG, F, PARSONS, J. N, O'KEEFE, S. J, PARSONS, W. H

“…Tacrolimus (FK506) is an immunosuppressive drug 50-100 times more potent than cyclosporine (CsA), the current mainstay of organ transplant rejection therapy…”
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A Filter-Based, 96-Well Microtiter Plate Calcineurin Phosphatase Assay by Martin, Mary M., Wiederrecht, Gregory J.

“…A rapid, sensitive, and specific filter-based assay for calcineurin phosphatase that utilizes a 96-well microtiter plate format throughout is described. In…”
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Affinity Purification of the Ryanodine Receptor/Calcium Release Channel from Fast Twitch Skeletal Muscle Based on Its Tight Association with FKBP12 by Xin, H.B., Timerman, A.P., Onoue, H., Wiederrecht, G.J., Fleischer, S.

“…The ryanodine receptor (RyR)/calcium release channel isolated from skeletal muscle terminal cisternae (TC) of sarcoplasmic reticulum (SR) is tightly associated…”
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C32-O-imidazol-2-yl-methyl ether derivatives of the immunosuppressant ascomycin with improved therapeutic potential by Goulet, Mark T., McAlpine, Shelli R., Staruch, Mary Jo, Koprak, Samuel, Dumont, Francis J., Cryan, John G., Wiederrecht, Gregory J., Rosa, Raymond, Wilusz, Mary Beth, Peterson, Laurence B., Wyvratt, Matthew J., Parsons, William H.

“…A series of C32-O-aralkyl ether derivatives of the FK-506 related macrolide ascomycin have been prepared based on an earlier reported C32-O-cinnamyl ether…”
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C32-O-phenalkyl ether derivatives of the immunosuppressant ascomycin: a tether length study by Goulet, Mark T., Sinclair, Peter J., Wong, Frederick, Staruch, Mary Jo, Dumont, Francis J., Cryan, John G., Wiederrecht, Gregory J., Wyvratt, Matthew J., Parsons, William H.

“…A tether length study of C32-O-phenalkyl ether derivatives of ascomycin was conducted wherein it was determined that a 2-carbon tether provides optimum in…”
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Potent immunosuppressive C32-O-arylethyl ether derivatives of ascomycin with reduced toxicity by Armstrong, Helen M., Wong, Frederick, Holmes, Mark A., Sinclair, Peter J., Goulet, Mark T., Dumont, Francis J., Staruch, MaryJo, Koprak, Samuel, Peterson, Laurence B., Rosa, Raymond, Wilusz, Mary Beth, Wiederrecht, Gregory J., Cryan, John G., Wyvratt, Matthew J., Parsons, William H.

“…The synthesis of C32-O-arylethyl ether derivatives of ascomycin that possess equivalent immunosuppressant activity but reduced toxicity, compared to FK-506, is…”
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Mechanism of action of rapamycin: new insights into the regulation of G1-phase progression in eukaryotic cells by Wiederrecht, G J, Sabers, C J, Brunn, G J, Martin, M M, Dumont, F J, Abraham, R T

“…The immunosuppressant drug, rapamycin (RAP), is a potent inhibitor of IL-2-dependent T-cell proliferation. The antiproliferative effect of RAP is mediated…”
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