Search Results - "Wiedau‐Pazos, Martina"

Assessment of feasibility and utility of universal referral to specialty palliative care in a multidisciplinary amyotrophic lateral sclerosis clinic: A cohort study by Hafer, Julia, Jensen, Sarah, Wiedau‐Pazos, Martina, Mehta, Ambereen K.

“…Introduction Although the value of palliative care integration in multidisciplinary amyotrophic lateral sclerosis (ALS) clinics has been increasingly…”
Get full text

Long‐term edaravone efficacy in amyotrophic lateral sclerosis: Post‐hoc analyses of Study 19 (MCI186‐19) by Shefner, Jeremy, Heiman‐Patterson, Terry, Pioro, Erik P., Wiedau‐Pazos, Martina, Liu, Shawn, Zhang, Jeffrey, Agnese, Wendy, Apple, Stephen

“…Background In a Phase 3 study, amyotrophic lateral sclerosis (ALS) patients experienced significantly less physical functional decline with 24‐week edaravone…”
Get full text

Longitudinal specialty palliative care for people with amyotrophic lateral sclerosis using a universal referral method by Jensen, Sarah, Hafer, Julia, Wiedau‐Pazos, Martina, Mehta, Ambereen K.

Get full text

Mexiletine for muscle cramps in amyotrophic lateral sclerosis: A randomized, double‐blind crossover trial by Oskarsson, Björn, Moore, Dan, Mozaffar, Tahseen, Ravits, John, Wiedau‐Pazos, Martina, Parziale, Nicholas, Joyce, Nanette C., Mandeville, Ross, Goyal, Namita, Cudkowicz, Merit E., Weiss, Michael, Miller, Robert G., McDonald, Craig M.

“…ABSTRACT Introduction: More than 90% of amyotrophic lateral sclerosis (ALS) patients have muscle cramps, but evidence‐based treatments have not been available…”
Get full text

Directed Differentiation of Human‐Induced Pluripotent Stem Cells Generates Active Motor Neurons by Karumbayaram, Saravanan, Novitch, Bennett G., Patterson, Michaela, Umbach, Joy A., Richter, Laura, Lindgren, Anne, Conway, Anne E., Clark, Amander T., Goldman, Steve A., Plath, Kathrin, Wiedau‐pazos, Martina, Kornblum, Harley I., Lowry, William E.

“…The potential for directed differentiation of human‐induced pluripotent stem (iPS) cells to functional postmitotic neuronal phenotypes is unknown. Following…”
Get full text

Induction of Nrf2 and xCT are involved in the action of the neuroprotective antibiotic ceftriaxone in vitro by Lewerenz, Jan, Albrecht, Philipp, Tien, Mai-Ly Tran, Henke, Nadine, Karumbayaram, Saravanan, Kornblum, Harley I, Wiedau-Pazos, Martina, Schubert, Dave, Maher, Pamela, Methner, Axel

“…In amyotrophic lateral sclerosis, down-regulation of the astrocyte-specific glutamate excitatory amino acid transporter 2 is hypothesized to increase…”
Get full text

IL-17A is increased in the serum and in spinal cord CD8 and mast cells of ALS patients by Fiala, Milan, Chattopadhay, Madhuri, La Cava, Antonio, Tse, Eric, Liu, Guanghao, Lourenco, Elaine, Eskin, Ascia, Liu, Philip T, Magpantay, Larry, Tse, Stephen, Mahanian, Michelle, Weitzman, Rachel, Tong, Jason, Nguyen, Caroline, Cho, Tiffany, Koo, Patrick, Sayre, James, Martinez-Maza, Otoniel, Rosenthal, Mark J, Wiedau-Pazos, Martina

“…The contribution of inflammation to neurodegenerative diseases is increasingly recognized, but the role of inflammation in sporadic amyotrophic lateral…”
Get full text

Edaravone efficacy in amyotrophic lateral sclerosis with reduced forced vital capacity: Post-hoc analysis of Study 19 (MCI186-19) [clinical trial NCT01492686] by Brooks, Benjamin Rix, Heiman-Patterson, Terry, Wiedau-Pazos, Martina, Liu, Shawn, Zhang, Jeffrey, Apple, Stephen

“…Edaravone slowed the rate of functional decline in subjects with amyotrophic lateral sclerosis (ALS) in phase 3 study MCI186-19 (Study 19). One of the Study 19…”
Get full text

Transcriptome analysis in whole blood reveals increased microbial diversity in schizophrenia by Olde Loohuis, Loes M., Mangul, Serghei, Ori, Anil P. S., Jospin, Guillaume, Koslicki, David, Yang, Harry Taegyun, Wu, Timothy, Boks, Marco P., Lomen-Hoerth, Catherine, Wiedau-Pazos, Martina, Cantor, Rita M., de Vos, Willem M., Kahn, René S., Eskin, Eleazar, Ophoff, Roel A.

“…The role of the human microbiome in health and disease is increasingly appreciated. We studied the composition of microbial communities present in blood across…”
Get full text

Resurgent Na+ Current Offers Noise Modulation in Bursting Neurons by Venugopal, Sharmila, Seki, Soju, Terman, David H, Pantazis, Antonios, Olcese, Riccardo, Wiedau-Pazos, Martina, Chandler, Scott H

“…Neurons utilize bursts of action potentials as an efficient and reliable way to encode information. It is likely that the intrinsic membrane properties of…”
Get full text

Charcot-Marie-Tooth disease CMT4A: GDAP1 increases cellular glutathione and the mitochondrial membrane potential by Noack, Rebecca, Frede, Svenja, Albrecht, Philipp, Henke, Nadine, Pfeiffer, Annika, Knoll, Katrin, Dehmel, Thomas, Meyer zu Hörste, Gerd, Stettner, Mark, Kieseier, Bernd C., Summer, Holger, Golz, Stefan, Kochanski, Andrzej, Wiedau-Pazos, Martina, Arnold, Susanne, Lewerenz, Jan, Methner, Axel

“…Mutations in GDAP1 lead to recessively or dominantly inherited peripheral neuropathies (Charcot-Marie-Tooth disease, CMT), indicating that GDAP1 is essential…”
Get full text

Integrative gene–tissue microarray-based approach for identification of human disease biomarkers: application to amyotrophic lateral sclerosis by Kudo, Lili C., Parfenova, Liubov, Vi, Nancy, Lau, Kimbley, Pomakian, Justine, Valdmanis, Paul, Rouleau, Guy A., Vinters, Harry V., Wiedau-Pazos, Martina, Karsten, Stanislav L.

“…Advances in genomics and proteomics permit rapid identification of disease-relevant genes and proteins. Challenges include biological differences between…”
Get full text

A Genomic Screen for Modifiers of Tauopathy Identifies Puromycin-Sensitive Aminopeptidase as an Inhibitor of Tau-Induced Neurodegeneration by Karsten, Stanislav L., Sang, Tzu-Kang, Gehman, Lauren T., Chatterjee, Shreyasi, Liu, Jiankai, Lawless, George M., Sengupta, Soma, Berry, Robert W., Pomakian, Justine, Oh, Hyun S., Schulz, Cordula, Hui, Koon-Sea, Wiedau-Pazos, Martina, Vinters, Harry V., Binder, Lester I., Geschwind, Daniel H., Jackson, George R.

“…Neurofibrillary tangles (NFT) containing tau are a hallmark of neurodegenerative diseases, including Alzheimer's disease (AD). NFT burden correlates with…”
Get full text

Wnt-pathway activation during the early stage of neurodegeneration in FTDP-17 mice by Wiedau-Pazos, Martina, Wong, Eugene, Solomon, Esther, Alarcon, Maricela, Geschwind, Daniel H

“…Abstract Glycogen synthase kinase-3beta (GSK-3β), a key component of the Wnt signaling pathway, has been recognized as an important tau kinase with a potential…”
Get full text

Altered Reactivity of Superoxide Dismutase in Familial Amyotrophic Lateral Sclerosis by Wiedau-Pazos, Martina, Goto, Joy J., Rabizadeh, Shahrooz, Gralla, Edith B., Roe, James A., Lee, Michael K., Valentine, Joan S., Bredesen, Dale E.

“…A subset of individuals with familial amyotrophic lateral sclerosis (FALS) possesses dominantly inherited mutations in the gene that encodes copper-zinc…”
Get full text

Human embryonic stem cell-derived motor neurons expressing SOD1 mutants exhibit typical signs of motor neuron degeneration linked to ALS by Karumbayaram, Saravanan, Kelly, Theresa K, Paucar, Andres A, Roe, Anne J T, Umbach, Joy A, Charles, Andrew, Goldman, Steven A, Kornblum, Harley I, Wiedau-Pazos, Martina

“…Human embryonic stem cell (hESC)-derived neurons have the potential to model neurodegenerative disorders. Here, we demonstrate the expression of a mutant gene,…”
Get full text

Puromycin-sensitive aminopeptidase (PSA/NPEPPS) impedes development of neuropathology in hPSA/TAUP301L double-transgenic mice by Kudo, Lili C., Parfenova, Liubov, Ren, Guijie, Vi, Nancy, Hui, Maria, Ma, Zhongcai, Lau, Kimbley, Gray, Michelle, Bardag-Gorce, Fawzia, Wiedau-Pazos, Martina, Hui, Koon-Sea, Karsten, Stanislav L.

Get full text

Circuit-Specific Early Impairment of Proprioceptive Sensory Neurons in the SOD1(G93A) Mouse Model for ALS by Seki, Soju, Yamamoto, Toru, Quinn, Kiara, Spigelman, Igor, Pantazis, Antonios, Olcese, Riccardo, Wiedau-Pazos, Martina, Chandler, Scott H., Venugopal, Sharmila

“…Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease in which motor neurons degenerate, resulting in muscle atrophy, paralysis, and fatality…”
Get full text

Circuit-Specific Early Impairment of Proprioceptive Sensory Neurons in the SOD1G93A Mouse Model for ALS by Seki, Soju, Yamamoto, Toru, Quinn, Kiara, Spigelman, Igor, Pantazis, Antonios, Olcese, Riccardo, Wiedau-Pazos, Martina, Chandler, Scott H, Venugopal, Sharmila

“…Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease in which motor neurons degenerate, resulting in muscle atrophy, paralysis, and fatality…”
Get full text

Palliative Care Consults in an Inpatient Setting for Patients With Amyotrophic Lateral Sclerosis by Mehta, Ambereen K., Jackson, Nicholas J., Wiedau-Pazos, Martina

“…Background: Limited data about the frequency and outcomes of palliative care (PC) specialty consultations for patients with amyotrophic lateral sclerosis (ALS)…”
Get full text