Search Results - "Wieczorek, David F."

Cardiac myosin light chain phosphorylation and inotropic effects of a biased ligand, TRV120023, in a dilated cardiomyopathy model by Tarigopula, Madhusudhan, Davis, 3rd, Robert T, Mungai, Paul T, Ryba, David M, Wieczorek, David F, Cowan, Conrad L, Violin, Jonathan D, Wolska, Beata M, Solaro, R John

“…Therapeutic approaches to treat familial dilated cardiomyopathy (DCM), which is characterized by depressed sarcomeric tension and susceptibility to…”
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Molecular and Functional Characterization of a Novel Cardiac-Specific Human Tropomyosin Isoform by RAJAN, Sudarsan, JAGATHEESAN, Ganapathy, DUBE, Dipak K, PETRASHEVSKAYA, Natalia, HERR, Andrew B, HULLIN, Roger, LIGGETT, Stephen B, WOLSKA, Beata M, SOLARO, R. John, WIECZOREK, David F, KARAM, Chehade N, ALVES, Marco L, BODI, Ilona, SCHWARTZ, Arnold, BULCAO, Christian F, D'SOUZA, Karen M, AKHTER, Shahab A, BOIVIN, Greg P

“…Tropomyosin (TM), an essential actin-binding protein, is central to the control of calcium-regulated striated muscle contraction. Although TPM1alpha (also…”
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Prevention of Cardiac Hypertrophy in Mice by Calcineurin Inhibition by Sussman, Mark A., Lim, Hae W., Gude, Natalie, Taigen, Tyler, Olson, Eric N., Robbins, Jeffrey, Colbert, Melissa C., Gualberto, Antonio, Wieczorek, David F., Molkentin, Jeffery D.

“…Hypertrophic cardiomyopathy (HCM) is an inherited form of heart disease that affects 1 in 500 individuals. Here it is shown that calcineurin, a…”
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Microarray analysis of active cardiac remodeling genes in a familial hypertrophic cardiomyopathy mouse model rescued by a phospholamban knockout by Rajan, Sudarsan, Pena, James R, Jegga, Anil G, Aronow, Bruce J, Wolska, Beata M, Wieczorek, David F

“…Familial hypertrophic cardiomyopathy (FHC) is a disease characterized by ventricular hypertrophy, fibrosis, and aberrant systolic and/or diastolic function…”
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Divergent Regulation of the Sarcomere and the Cytoskeleton by Schevzov, Galina, Fath, Thomas, Vrhovski, Bernadette, Vlahovich, Nicole, Rajan, Sudarsan, Hook, Jeff, Joya, Josephine E., Lemckert, Frances, Puttur, Franz, Lin, Jim J.-C., Hardeman, Edna C., Wieczorek, David F., O'Neill, Geraldine M., Gunning, Peter W.

“…The existence of a feedback mechanism regulating the precise amounts of muscle structural proteins, such as actin and the actin-associated protein tropomyosin…”
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N-acetylcysteine reverses diastolic dysfunction and hypertrophy in familial hypertrophic cardiomyopathy by Wilder, Tanganyika, Ryba, David M, Wieczorek, David F, Wolska, Beata M, Solaro, R John

“…S-glutathionylation of cardiac myosin-binding protein C (cMyBP-C) induces Ca(2+) sensitization and a slowing of cross-bridge kinetics as a result of increased…”
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Investigations into tropomyosin function using mouse models by Jagatheesan, Ganapathy, Rajan, Sudarsan, Wieczorek, David F

“…Abstract Tropomyosin plays a key role in controlling calcium regulated sarcomeric contraction through its interactions with actin and the troponin complex. The…”
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Tropomyosin pseudo-phosphorylation results in dilated cardiomyopathy by Rajan, Sudarsan, Jagatheesan, Ganapathy, Petrashevskaya, Natalia, Biesiadecki, Brandon J., Warren, Chad M., Riddle, Tara, Liggett, Stephen, Wolska, Beata M., Solaro, R. John, Wieczorek, David F.

“…Phosphorylation of cardiac sarcomeric proteins plays a major role in the regulation of the physiological performance of the heart. Phosphorylation of thin…”
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Microarray analysis of gene expression during early stages of mild and severe cardiac hypertrophy by Rajan, Sudarsan, Williams, Sarah S, Jagatheesan, Ganapathy, Ahmed, Rafeeq P. H, Fuller-Bicer, Geraldine, Schwartz, Arnold, Aronow, Bruce J, Wieczorek, David F

“…1 Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati College of Medicine, Cincinnati, Ohio 2 Division of Biomedical…”
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Identification of two new regions in the N‐terminus of cardiac troponin T that have divergent effects on cardiac contractile function by Mamidi, Ranganath, Mallampalli, Sri Lakshmi, Wieczorek, David F., Chandra, Murali

“…Key points To elucidate the cardiac‐specific role of the highly acidic extended N‐terminus of cardiac troponin T (cTnT), the following deletions were made in…”
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Sphingosine-1-Phosphate Receptor Modulator, FTY720, Improves Diastolic Dysfunction and Partially Reverses Atrial Remodeling in a Tm-E180G Mouse Model Linked to Hypertrophic Cardiomyopathy by Ryba, David M, Warren, Chad M, Karam, Chehade N, Davis, 3rd, Robert T, Chowdhury, Shamim A K, Alvarez, Manuel G, McCann, Maximilian, Liew, Chong Wee, Wieczorek, David F, Varga, Peter, Solaro, R John, Wolska, Beata M

“…Hypertrophic cardiomyopathy (HCM) is a genetic cardiovascular disorder, primarily involving mutations in sarcomeric proteins. HCM patients present with…”
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Myocardial Infarction-induced N-terminal Fragment of Cardiac Myosin-binding Protein C (cMyBP-C) Impairs Myofilament Function in Human Myocardium by Witayavanitkul, Namthip, Ait Mou, Younss, Kuster, Diederik W.D., Khairallah, Ramzi J., Sarkey, Jason, Govindan, Suresh, Chen, Xin, Ge, Ying, Rajan, Sudarsan, Wieczorek, David F., Irving, Thomas, Westfall, Margaret V., de Tombe, Pieter P., Sadayappan, Sakthivel

“…Myocardial infarction (MI) is associated with depressed cardiac contractile function and progression to heart failure. Cardiac myosin-binding protein C, a…”
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Early sensitization of myofilaments to Ca2+ prevents genetically linked dilated cardiomyopathy in mice by Alves, Marco L, Warren, Chad M, Simon, Jillian N, Gaffin, Robert D, Montminy, Eric M, Wieczorek, David F, Solaro, R John, Wolska, Beata M

“…Dilated cardiomoypathies (DCM) are a heterogeneous group of inherited and acquired diseases characterized by decreased contractility and enlargement of cardiac…”
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The role of tropomyosin in the regulation of myocardial contraction and relaxation by Wolska, Beata M, Wieczorek, David M F

“…Studies over the last 30 years have demonstrated the essential nature of the evolutionarily highly conserved tropomyosin (TM) protein. TM-deficient cells…”
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Functional Importance of the Carboxyl-terminal Region of Striated Muscle Tropomyosin by Jagatheesan, Ganapathy, Rajan, Sudarsan, Petrashevskaya, Natalia, Schwartz, Arnold, Boivin, Greg, Vahebi, Susan, DeTombe, Pieter, Solaro, R John, Labitzke, Erin, Hilliard, George, Wieczorek, David F

“…Striated muscle tropomyosin (TM) interacts with actin and the troponin complex to regulate calcium-mediated muscle contraction. Previous work by our laboratory…”
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The role of tropomyosin in heart disease by Wieczorek, David F, Jagatheesan, Ganapathy, Rajan, Sudarsan

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Desensitization of myofilaments to Ca2+ as a therapeutic target for hypertrophic cardiomyopathy with mutations in thin filament proteins by Alves, Marco L, Dias, Fernando A L, Gaffin, Robert D, Simon, Jillian N, Montminy, Eric M, Biesiadecki, Brandon J, Hinken, Aaron C, Warren, Chad M, Utter, Megan S, Davis, Rd, Robert T, Sakthivel, Sadayappan, Robbins, Jeffrey, Wieczorek, David F, Solaro, R John, Wolska, Beata M

“…Hypertrophic cardiomyopathy (HCM) is a common genetic disorder caused mainly by mutations in sarcomeric proteins and is characterized by maladaptive myocardial…”
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Conserved Asp-137 Is Important for both Structure and Regulatory Functions of Cardiac α-Tropomyosin (α-TM) in a Novel Transgenic Mouse Model Expressing α-TM-D137L by Yar, Sumeyye, Chowdhury, Shamim A.K., Davis, Robert T., Kobayashi, Minae, Monasky, Michelle M., Rajan, Sudarsan, Wolska, Beata M., Gaponenko, Vadim, Kobayashi, Tomoyoshi, Wieczorek, David F., Solaro, R. John

“…α-Tropomyosin (α-TM) has a conserved, charged Asp-137 residue located in the hydrophobic core of its coiled-coil structure, which is unusual in that the…”
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Ablation of plasma membrane Ca(2+)-ATPase isoform 4 prevents development of hypertrophy in a model of hypertrophic cardiomyopathy by Prasad, Vikram, Lorenz, John N, Lasko, Valerie M, Nieman, Michelle L, Jiang, Min, Gao, Xu, Rubinstein, Jack, Wieczorek, David F, Shull, Gary E

“…The mechanisms linking the expression of sarcomeric mutant proteins to the development of pathological hypertrophy in hypertrophic cardiomyopathy (HCM) remain…”
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Decreasing Tropomyosin Phosphorylation Rescues Tropomyosin-induced Familial Hypertrophic Cardiomyopathy by Schulz, Emily M., Wilder, Tanganyika, Chowdhury, Shamim A.K., Sheikh, Hajer N., Wolska, Beata M., Solaro, R. John, Wieczorek, David F.

“…Increased calcium uptake can rescue congenital cardiomyopathies. Results: Decreasing tropomyosin phosphorylation increases phospholamban phosphorylation and…”
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