Search Results - "Wieckowski, Sebastien"

Exhaustion of tumor-specific CD8⁺ T cells in metastases from melanoma patients by Baitsch, Lukas, Baumgaertner, Petra, Devêvre, Estelle, Raghav, Sunil K, Legat, Amandine, Barba, Leticia, Wieckowski, Sébastien, Bouzourene, Hanifa, Deplancke, Bart, Romero, Pedro, Rufer, Nathalie, Speiser, Daniel E

“…In chronic viral infections, CD8⁺ T cells become functionally deficient and display multiple molecular alterations. In contrast, only little is known of self-…”
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Toward a Better Understanding of Bioassays for the Development of Biopharmaceuticals by Exploring the Structure-Antibody-Dependent Cellular Cytotoxicity Relationship in Human Primary Cells by Wieckowski, Sébastien, Avenal, Cécile, Orjalo, Jr, Arturo V, Gygax, Daniel, Cymer, Florian

“…Pharmaceutical manufacturing relies on rigorous methods of quality control of drugs and in particular of the physico-chemical and functional characterizations…”
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GEF-H1 Signaling upon Microtubule Destabilization Is Required for Dendritic Cell Activation and Specific Anti-tumor Responses by Kashyap, Abhishek S., Fernandez-Rodriguez, Laura, Zhao, Yun, Monaco, Gianni, Trefny, Marcel P., Yoshida, Naohiro, Martin, Kea, Sharma, Ashwani, Olieric, Natacha, Shah, Pankaj, Stanczak, Michal, Kirchhammer, Nicole, Park, Sung-Moo, Wieckowski, Sebastien, Laubli, Heinz, Zagani, Rachid, Kasenda, Benjamin, Steinmetz, Michel O., Reinecker, Hans-Christian, Zippelius, Alfred

“…Dendritic cell (DC) activation is a critical step for anti-tumor T cell responses. Certain chemotherapeutics can influence DC function. Here we demonstrate…”
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Quantitative TCR:pMHC Dissociation Rate Assessment by NTAmers Reveals Antimelanoma T Cell Repertoires Enriched for High Functional Competence by Gannon, Philippe O, Wieckowski, Sébastien, Baumgaertner, Petra, Hebeisen, Michaël, Allard, Mathilde, Speiser, Daniel E, Rufer, Nathalie

“…Experimental models demonstrated that therapeutic induction of CD8 T cell responses may offer protection against tumors or infectious diseases providing that T…”
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Therapeutic efficacy of the F8-IL2 immunocytokine in a metastatic mouse model of lung adenocarcinoma by Wieckowski, Sébastien, Hemmerle, Teresa, Prince, Spasenja Savic, Schlienger, Béatrice Dolder, Hillinger, Sven, Neri, Dario, Zippelius, Alfred

“…Highlights • The F8-IL2 immunocytokine was evaluated in a metastatic mouse model of NSCLC. • F8-IL2 induced locally a favorable immunologic anti-tumor…”
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Single cell analysis reveals similar functional competence of dominant and nondominant CD8 T-cell clonotypes by Speiser, Daniel E, Wieckowski, Sébastien, Gupta, Bhawna, Iancu, Emanuela M, Baumgaertner, Petra, Baitsch, Lukas, Michielin, Olivier, Romero, Pedro, Rufer, Nathalie

“…Immune protection from infectious diseases and cancer is mediated by individual T cells of different clonal origin. Their functions are tightly regulated but…”
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TCRep 3D: an automated in silico approach to study the structural properties of TCR repertoires by Leimgruber, Antoine, Ferber, Mathias, Irving, Melita, Hussain-Kahn, Hamid, Wieckowski, Sébastien, Derré, Laurent, Rufer, Nathalie, Zoete, Vincent, Michielin, Olivier

“…TCRep 3D is an automated systematic approach for TCR-peptide-MHC class I structure prediction, based on homology and ab initio modeling. It has been…”
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Enhanced cytotoxicity and decreased CD8 dependence of human cancer-specific cytotoxic T lymphocytes after vaccination with low peptide dose by Lövgren, Tanja, Baumgaertner, Petra, Wieckowski, Sébastien, Devêvre, Estelle, Guillaume, Philippe, Luescher, Immanuel, Rufer, Nathalie, Speiser, Daniel E.

“…In mice, vaccination with high peptide doses generates higher frequencies of specific CD8+ T cells, but with lower avidity compared to vaccination with lower…”
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Simultaneous Coexpression of Memory-related and Effector-related Genes by Individual Human CD8 T Cells Depends on Antigen Specificity and Differentiation by GUPTA, Bhawna, IANCU, Emanuela M, GANNON, Philippe O, WIECKOWSKI, Sébastien, BAITSCH, Lukas, SPEISER, Daniel E, RUFER, Nathalie

“…Phenotypic and functional cell properties are usually analyzed at the level of defined cell populations but not single cells. Yet, large differences between…”
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Profile of a Serial Killer : Cellular and Molecular Approaches to Study Individual Cytotoxic T-Cells following Therapeutic Vaccination by Iancu, Emanuela M., Baumgaertner, Petra, Wieckowski, Sébastien, Speiser, Daniel E., Rufer, Nathalie

“…T-cell vaccination may prevent or treat cancer and infectious diseases, but further progress is required to increase clinical efficacy. Step-by-step…”
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Cellular uptake of functionalized carbon nanotubes is independent of functional group and cell type by Kostarelos, Kostas, Prato, Maurizio, Bianco, Alberto, Lacerda, Lara, Pastorin, Giorgia, Wu, Wei, Wieckowski, Sébastien, Luangsivilay, Jacqueline, Godefroy, Sylvie, Pantarotto, Davide, Briand, Jean-Paul, Muller, Sylviane

“…The development of nanomaterials for biomedical and biotechnological applications is an area of research that holds great promise and intense interest, and…”
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Immunomodulatory consequences of ODN CpG-polycation complexes by Partidos, Charalambos D., Hoebeke, Johan, Wieckowski, Sébastien, Chaloin, Olivier, Bianco, Alberto, Moreau, Emmanuel, Briand, Jean-Paul, Desgranges, Claude, Muller, Sylviane

“…Immunostimulatory ODN CpGs have extensively been tested as adjuvants and immunotherapeutics and hold a lot of promise for human use. In our studies we took…”
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Rationally-designed multivalent architectures for mimicking homotrimers of CD40L, a member of the TNF superfamily by Guichard, Gilles, Trouche, Nathalie, Wieckowski, Sébastien, Sun, Weimin, Chaloin, Olivier, Bianco, Alberto, Hoebeke, Johan, Schneider, Pascal, Fournel, Sylvie

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Cooperativity in the Interaction of Synthetic CD40L Mimetics with CD40 and Its Implication in Cell Signaling by Wieckowski, Sébastien, Trouche, Nathalie, Chaloin, Olivier, Guichard, Gilles, Fournel, Sylvie, Hoebeke, Johan

“…CD40 ligand (CD40L) and CD40 are members of the tumor necrosis factor (TNF) and TNF receptor superfamilies, respectively. Their interaction is crucial for the…”
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Targeted Delivery of Amphotericin B to Cells by Using Functionalized Carbon Nanotubes by Wu, Wei, Wieckowski, Sébastien, Pastorin, Giorgia, Benincasa, Monica, Klumpp, Cédric, Briand, Jean-Paul, Gennaro, Renato, Prato, Maurizio, Bianco, Alberto

“…Tasty tubes: Multiwalled carbon nanotubes functionalized with fluorescein isothiocyanate and amphotericin B (AmB) have been shown to be rapidly internalized by…”
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A phase 1 trial extension to assess immunologic efficacy and safety of prime-boost vaccination with VXM01, an oral T cell vaccine against VEGFR2, in patients with advanced pancreatic cancer by Schmitz-Winnenthal, Friedrich H., Hohmann, Nicolas, Schmidt, Thomas, Podola, Lilli, Friedrich, Tobias, Lubenau, Heinz, Springer, Marco, Wieckowski, Sébastien, Breiner, Klaus M., Mikus, Gerd, Büchler, Markus W., Keller, Anne-Valerie, Koc, Ruhan, Springfeld, Christoph, Knebel, Phillip, Bucur, Mariana, Grenacher, Lars, Haefeli, Walter E., Beckhove, Philipp

“…VXM01 is a first-in-kind orally applied tumor vaccine based on live attenuated Salmonella typhi carrying an expression plasmid encoding VEGFR2, an antigen…”
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Fine Structural Variations of αβTCRs Selected by Vaccination with Natural versus Altered Self-Antigen in Melanoma Patients by Wieckowski, Sébastien, Baumgaertner, Petra, Corthesy, Patricia, Voelter, Verena, Romero, Pedro, Speiser, Daniel E., Rufer, Nathalie

“…Immunotherapy of cancer is often performed with altered “analog” peptide Ags optimized for HLA class I binding, resulting in enhanced immunogenicity, but the…”
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Tumor Antigen-Specific FOXP3+ CD4 T Cells Identified in Human Metastatic Melanoma: Peptide Vaccination Results in Selective Expansion of Th1-like Counterparts by JANDUS, Camilla, BIOLEY, Gilles, SPEISER, Daniel E, ROMERO, Pedro, DOJCINOVIC, Danijel, DERRE, Laurent, BAITSCH, Lukas, WIECKOWSKI, Sébastien, RUFER, Nathalie, KWOK, William W, TIERCY, Jean-Marie, LUESCHER, Immanuel F

“…We have previously shown that vaccination of HLA-A2 metastatic melanoma patients with the analogue Melan-A(26-35(A27L)) peptide emulsified in a mineral oil…”
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Small Multivalent Architectures Mimicking Homotrimers of the TNF Superfamily Member CD40L:  Delineating the Relationship between Structure and Effector Function by Trouche, Nathalie, Wieckowski, Sébastien, Sun, Weimin, Chaloin, Olivier, Hoebeke, Johan, Fournel, Sylvie, Guichard, Gilles

“…Synthetic multivalent ligands, owing to the presence of multiple copies of a recognition motif attached to a central scaffold, can mediate clustering of cell…”
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Cutting edge: small molecule CD40 ligand mimetics promote control of parasitemia and enhance T cells producing IFN-gamma during experimental Trypanosoma cruzi infection by Habib, Mohammed, Noval Rivas, Magali, Chamekh, Mustapha, Wieckowski, Sébastien, Sun, Weimin, Bianco, Alberto, Trouche, Nathalie, Chaloin, Olivier, Dumortier, Hélène, Goldman, Michel, Guichard, Gilles, Fournel, Sylvie, Vray, Bernard

“…Host resistance to Trypanosoma cruzi infection depends on a type 1 response characterized by a strong production of IL-12 and IFN-gamma. Amplifying this…”
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