Search Results - "Wieckowski, Eva"

Tumor-Derived Microvesicles Promote Regulatory T Cell Expansion and Induce Apoptosis in Tumor-Reactive Activated CD8+ T Lymphocytes by Wieckowski, Eva U, Visus, Carmen, Szajnik, Marta, Szczepanski, Miroslaw J, Storkus, Walter J, Whiteside, Theresa L

“…Sera of patients with cancer contain membraneous microvesicles (MV) able to induce apoptosis of activated T cells by activating the Fas/Fas ligand pathway…”
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Retraction for Billington et al., " Clostridium perfringens Type E Animal Enteritis Isolates with Highly Conserved, Silent Enterotoxin Gene Sequences" by Billington, Stephen J, Wieckowski, Eva U, Sarker, Mahfuzur R, Bueschel, Dawn, Songer, J Glenn, McClane, Bruce A

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First-in-man Study of Western Reserve Strain Oncolytic Vaccinia Virus: Safety, Systemic Spread, and Antitumor Activity by Zeh, Herbert J, Downs-Canner, Stephanie, McCart, J Andrea, Guo, Zong Sheng, Rao, Uma N M, Ramalingam, Lekshmi, Thorne, Stephen H, Jones, Heather L, Kalinski, Pawel, Wieckowski, Eva, O'Malley, Mark E, Daneshmand, Manijeh, Hu, Kang, Bell, John C, Hwang, Tae-Ho, Moon, Anne, Breitbach, Caroline J, Kirn, David H, Bartlett, David L

“…Oncolytic viral therapy utilizes a tumor-selective replicating virus which preferentially infects and destroys cancer cells and triggers antitumor immunity…”
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Fas Ligand–Positive Membranous Vesicles Isolated from Sera of Patients with Oral Cancer Induce Apoptosis of Activated T Lymphocytes by JEONG WHUN KIM, WIECKOWSKI, Eva, TAYLOR, Douglas D, REICHERT, Torsten E, WATKINS, Simon, WHITESIDE, Theresa L

“…Objective: In patients with oral squamous cell carcinoma, a high proportion of T cells in the tumor undergo apoptosis, which correlates with Fas ligand (FasL)…”
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A gynecologic oncology group phase II trial of two p53 peptide vaccine approaches: subcutaneous injection and intravenous pulsed dendritic cells in high recurrence risk ovarian cancer patients by Rahma, Osama E., Ashtar, Ed, Czystowska, Malgorzata, Szajnik, Marta E., Wieckowski, Eva, Bernstein, Sarah, Herrin, Vincent E., Shams, Mortada A., Steinberg, Seth M., Merino, Maria, Gooding, William, Visus, Carmen, DeLeo, Albert B., Wolf, Judith K., Bell, Jeffrey G., Berzofsky, Jay A., Whiteside, Theresa L., Khleif, Samir N.

“…Purpose Peptide antigens have been administered by different approaches as cancer vaccine therapy, including direct injection or pulsed onto dendritic cells;…”
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A Role for Mitochondrial Bak in Apoptotic Response to Anticancer Drugs by Wang, Gui-Qiang, Gastman, Brian R., Wieckowski, Eva, Goldstein, Leslie A., Gambotto, Andrea, Kim, Tae-Hyoung, Fang, Bingliang, Rabinovitz, Asaf, Yin, Xiao-Ming, Rabinowich, Hannah

“…In the present study a clonal Jurkat cell line deficient in expression of Bak was used to analyze the role of Bak in cytochrome c release from mitochondria…”
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Apoptosis-resistant Mitochondria in T Cells Selected for Resistance to Fas Signaling by Wang, Gui-Qiang, Gastman, Brian R., Wieckowski, Eva, Goldstein, Leslie A., Rabinovitz, Asaf, Yin, Xiao-Ming, Rabinowich, Hannah

“…Jurkat leukemic T cells are highly sensitive to the extrinsic pathways of apoptosis induced via the death receptor Fas or tumor necrosis factor-related…”
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Promoting the accumulation of tumor-specific T cells in tumor tissues by dendritic cell vaccines and chemokine-modulating agents by Obermajer, Nataša, Urban, Julie, Wieckowski, Eva, Muthuswamy, Ravikumar, Ravindranathan, Roshni, Bartlett, David L, Kalinski, Pawel

“…This protocol describes how to generate and use dendritic cells and combinatorial adjuvants to modulate tumor microenvironment and increase T-cell accumulation…”
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Ex vivo-induction of tumor-specific effector and memory T cells for adoptive T cell therapies using antigen-loaded DCs (TUM4P.910) by Hansen, Morten, Wieckowski, Eva, Kalinski, Pawel

“…Adoptive transfer of ex vivo expanded tumor infiltrating lymphocytes (TILs), or blood-derived T cells genetically-modified to express specific T cell receptors…”
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Identification of a Clostridium perfringens Enterotoxin Region Required for Large Complex Formation and Cytotoxicity by Random Mutagenesis by Kokai-Kun, J F, Benton, K, Wieckowski, E U, McClane, B A

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Clostridium perfringens Type E Animal Enteritis Isolates with Highly Conserved, Silent Enterotoxin Gene Sequences by BILLINGTON, S. J, WIECKOWSKI, E. U, SARKER, M. R, BUESCHEL, D, SONGER, J. G, MCCLANE, B. A

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Tumor-derived microvesicles in sera of patients with head and neck cancer and their role in tumor progression by Bergmann, Christoph, Strauss, Laura, Wieckowski, Eva, Czystowska, Malgorzata, Albers, Andreas, Wang, Yun, Zeidler, Reinhard, Lang, Stephan, Whiteside, Theresa L.

“…Background Tumor‐derived membranous vesicles (MV) isolated from sera of the patients with squamous cell carcinomas of the head and neck (HNSCC) induce…”
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Generation of stable Th1/CTL-, Th2-, and Th17-inducing human dendritic cells by Kalinski, Pawel, Wieckowski, Eva, Muthuswamy, Ravikumar, de Jong, Esther

“…Dendritic cells (DC) are the most potent inducers and regulators of immune responses, responsible for communication within immune system. The ability of DC to…”
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Human tumor-derived vs dendritic cell-derived exosomes have distinct biologic roles and molecular profiles by Wieckowski, Eva, Whiteside, Theresa L

“…Microvesicles (MV) or exosomes are produced and secreted by tumor and normal cells. The molecular profile and functions of tumor-derived vs dendritic cell…”
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Type-1 polarized dendritic cells loaded with apoptotic prostate cancer cells are potent inducers of CD8+ T cells against prostate cancer cells and defined prostate cancer-specific epitopes by Wieckowski, Eva, Chatta, Gurkamal S., Mailliard, Robbie M., Gooding, William, Palucka, Karolina, Banchereau, Jacques, Kalinski, Pawel

“…BACKGROUND In order to develop improved vaccines for patients with recurrent prostate cancer (PCa), we tested the feasibility of using type‐1 polarized…”
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Type-I Polarized Dendritic Cells Loaded with Apoptotic Prostate Cancer Cells Are Potent Inducers of CD8+ T cells against Prostate Cancer Cells and Defined Prostate Cancer-Specific Epitopes by WIECKOWSKI, Eva, CHATTA, Gurkamal S, MAILLIARD, Robbie M, GOODING, William, PALUCKA, Karolina, BANCHEREAU, Jacques, KALINSKI, Pawel

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Comparative Biochemical and Immunocytochemical Studies Reveal Differences in the Effects of Clostridium perfringens Enterotoxin on Polarized CaCo-2 CellsVersus Vero Cells by Singh, Usha, Mitic, Laura L., Wieckowski, Eva U., Anderson, James M., McClane, Bruce A.

“…Since most in vitrostudies exploring the action of Clostridium perfringensenterotoxin (CPE) utilize either Vero or CaCo-2 cells, the current study directly…”
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Characterization of Membrane-Associated Clostridium perfringens Enterotoxin following Pronase Treatment by WIECKOWSKI, E. U, KOKAI-KUN, J. F, MCCLANE, B. A

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Selective costimulation by IL-15R/IL-15, but not IL-2R/IL-2, allows the induction of high numbers of tumor-specific CD8+ T cells by human dendritic cells matured in conditions of acute inflammation by Hansen, Morten, Wieckowski, Eva, Svane, Inge Marie, Edwards, Robert P, Kalinski, Pawel

“…Conventional dendritic cells (DC) are believed to rely on membrane-bound IL-2Rα to trans-present soluble IL-2 and costimulate T cell activation and expansion…”
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Prolonged intralymphatic delivery of dendritic cells through implantable lymphatic ports in patients with advanced cancer by Radomski, Michal, Zeh, Herbert J, Edington, Howard D, Pingpank, James F, Butterfield, Lisa H, Whiteside, Theresa L, Wieckowski, Eva, Bartlett, David L, Kalinski, Pawel

“…The currently-used modes of administration of immunotherapeutic agents result in their limited delivery to the lymph nodes and/or require repetitive…”
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