Search Results - "Wiechen, K"

FAST: a randomised phase II study of zolbetuximab (IMAB362) plus EOX versus EOX alone for first-line treatment of advanced CLDN18.2-positive gastric and gastro-oesophageal adenocarcinoma by Sahin, U., Türeci, Ö., Manikhas, G., Lordick, F., Rusyn, A., Vynnychenko, I., Dudov, A., Bazin, I., Bondarenko, I., Melichar, B., Dhaene, K., Wiechen, K., Huber, C., Maurus, D., Arozullah, A., Park, J.W., Schuler, M., Al-Batran, S.-E.

“…Claudin 18.2 (CLDN18.2) is contained within normal gastric mucosa epithelial tight junctions; upon malignant transformation, CLDN18.2 epitopes become exposed…”
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A multicentre, phase IIa study of zolbetuximab as a single agent in patients with recurrent or refractory advanced adenocarcinoma of the stomach or lower oesophagus: the MONO study by Türeci, O., Sahin, U., Schulze-Bergkamen, H., Zvirbule, Z., Lordick, F., Koeberle, D., Thuss-Patience, P., Ettrich, T., Arnold, D., Bassermann, F., Al-Batran, S.E., Wiechen, K., Dhaene, K., Maurus, D., Gold, M., Huber, C., Krivoshik, A., Arozullah, A., Park, J.W., Schuler, M.

“…Claudin 18.2 (CLDN18.2) is physiologically confined to gastric mucosa tight junctions; however, upon malignant transformation, perturbations in cell polarity…”
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Two distinct functional effects of protein phosphatase inhibitors on guinea-pig cardiac L-type Ca2+ channels by Wiechen, K, Yue, D T, Herzig, S

“…1. The effects of the phosphatase inhibitors okadaic acid and calyculin A on single guinea-pig ventricular L-type Ca2+ channels were studied. The inactive…”
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Suppression of the c-erbB-2 gene product decreases transformation abilities but not the proliferation and secretion of proteases of SK-OV-3 ovarian cancer cells by WIECHEN, K, KARAASLAN, S, TURZYNSKI, A, DIETEL, M

“…The overexpression of the c-erbB-2 oncogene product has been reported in approximately 20-30% of human ovarian cancers and has been correlated with a poor…”
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Diagnostic difficulties before definitive treatment of an extragonadal retroperitoneal germ cell tumor by Lassmann, J, Wille, A, Wiechen, K, Taupitz, M, Loening, S.A

“…A primary extragonadal germ cell tumor of the retroperitoneum was diagnosed in a 47-year-old man without elevated serum alpha-fetoprotein, human chorionic…”
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Biochemical and electrophysiological mechanisms of the positive inotropic effect of calyculin A, a protein phosphatase inhibitor by Neumann, J, Bokník, P, Herzig, S, Schmitz, W, Scholz, H, Wiechen, K, Zimmermann, N

“…Calyculin A (CyA; 1 microM) increased the force of contraction in isolated guinea pig papillary muscles to 144% of control without affecting contraction…”
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Discordant results obtained for different methods of HER-2/neu testing in breast cancer: a question of standardization, automation and timing by LÜFTNER, D, HENSCHKE, P, KAFKA, A, ANAGNOSTOPOULOS, I, WIECHEN, K, GEPPERT, R, STEIN, H, WERNECKE, K. D, KREIENBERG, R, POSSINGER, K

“…HER-2/neu positivity is required for the selection of stage IV breast cancer patients for trastuzumab therapy. We compared the results of the recommended…”
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Caveolin-1 Is Down-Regulated in Human Ovarian Carcinoma and Acts as a Candidate Tumor Suppressor Gene by Wiechen, Kai, Diatchenko, Luda, Agoulnik, Alexander, Scharff, K. Michael, Schober, Hagen, Arlt, Katharina, Zhumabayeva, Bakhyt, Siebert, Paul D., Dietel, Manfred, Schäfer, Reinhold, Sers, Christine

“…To identify novel markers differentially expressed in ovarian cancer versus normal ovary, we hybridized microarrays with cDNAs derived from normal human…”
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Loss of Gelsolin expression in human ovarian carcinomas by Noske, Aurelia, Denkert, Carsten, Schober, Hagen, Sers, Christine, Zhumabayeva, Bakhyt, Weichert, Wilko, Dietel, Manfred, Wiechen, Kai

“…The ubiquitously expressed actin-binding protein, gelsolin, is known to play a role in the modulation of the actin network and in the regulation of cell growth…”
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Down-Regulation of Caveolin-1, a Candidate Tumor Suppressor Gene, in Sarcomas by Wiechen, Kai, Sers, Christine, Agoulnik, Alexander, Arlt, Katharina, Dietel, Manfred, Schlag, Peter M., Schneider, Ulrike

“…Caveolae are plasma membrane microdomains that have been implicated in the regulation of several intracellular signaling pathways. Previous studies suggest…”
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A multicentre, phase IIa study of zolbetuximab as a single agent in patients with recurrent or refractory advanced adenocarcinoma of the stomach or lower oesophagus: the MONO study by Türeci, O, Sahin, U, Schulze-Bergkamen, H, Zvirbule, Z, Lordick, F, Koeberle, D, Thuss-Patience, P, Ettrich, T, Arnold, D, Bassermann, F, Al-Batran, S E, Wiechen, K, Dhaene, K, Maurus, D, Gold, M, Huber, C, Krivoshik, A, Arozullah, A, Park, J W, Schuler, M

“…Claudin 18.2 (CLDN18.2) is physiologically confined to gastric mucosa tight junctions; however, upon malignant transformation, perturbations in cell polarity…”
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Systematic identification and molecular characterization of genes differentially expressed in breast and ovarian cancer by Dahl, Edgar, Sadr-Nabavi, Ariane, Klopocki, Eva, Betz, Beate, Grube, Susanne, Kreutzfeld, Rene, Himmelfarb, Marina, An, Han-Xiang, Gelling, Stephen, Klaman, Irina, Hinzmann, Bernd, Kristiansen, Glen, Grützmann, Robert, Kuner, Ruprecht, Petschke, Beate, Rhiem, Kerstin, Wiechen, Kai, Sers, Christine, Wiestler, Otmar, Schneider, Achim, Höfler, Heinz, Nährig, Jörg, Dietel, Manfred, Schäfer, Reinhold, Rosenthal, André, Schmutzler, Rita, Dürst, Matthias, Meindl, Alfons, Niederacher, Dieter

“…The identification of novel disease‐associated genes in gynaecological tumours has important implications for understanding the process of tumourigenesis and…”
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The class II tumour suppressor gene H-REV107-1 is a target of interferon-regulatory factor-1 and is involved in IFNγ-induced cell death in human ovarian carcinoma cells by SERS, Christine, HUSMANN, Knut, NAZARENKO, Irina, REICH, Steffen, KAI WIECHEN, ZHUMABAYEVA, Bakhyt, ADHIKARI, Punam, SCHRÖDER, Katharina, GONTAREWICZ, Artur, SCHÄFER, Reinhold

“…H-rev107-1 is a growth inhibitory RAS target gene capable of suppressing anchorage independent growth in vitro and in vivo. Using a tumour tissue array with…”
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Antisense phosphorothioate oligodeoxynucleotide down‐regulation of the insulin‐like growth factor I receptor in ovarian cancer cells by Müller, Markus, Dietel, Manfred, Turzynski, Andreas, Wiechen, Kai

“…The insulin‐like growth factors (IGF‐I and IGF‐II) play a key role in cellular proliferation and are involved in cellular transformation. The expression of the…”
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Formalin-fixed blood clots--additional histological findings on computed tomography-guided fine-needle aspiration biopsies in comparison with core biopsies by Althoff, Christian E, Hermann, Kay-Geert A, Wiechen, Kai, Lembcke, Alexander, Enzweiler, Christian N H, Hamm, Bernd, Rogalla, Patrik

“…We investigated the diagnostic yield of histological examined formalin-fixed blood clots (FFBCs) in comparison with the established procedures of fine-needle…”
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Selection of a high activity c-erbB-2 ribozyme using a fusion gene of c-erbB-2 and the enhanced green fluorescent protein by Wiechen, K, Zimmer, C, Dietel, M

“…In different types of human cancer there is an overexpression of the c-erbB-2 (HER2/neu) oncogene, which is thought to be involved in tumor progression…”
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Involvement of the c‐erbB‐2 oncogene product in the egf‐induced cell motility of sk‐ov‐3 ovarian cancer cells by Wiechen, Kai, Karaaslan, Selma, Dietel, Manfred

“…The epidermal growth factor (EGF) induces the rapid formation of dendritic processes and the dissociation of SK‐OV‐3 ovarian cancer cells. The SK‐OV‐3 cell…”
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The class II tumour suppressor gene H-REV107-1 is a target of interferon-regulatory factor-1 and is involved in IFN gamma -induced cell death in human ovarian carcinoma cells by Sers, C, Husmann, K, Nazarenko, I, Reich, S, Wiechen, K, Zhumabayeva, B, Adhikari, P, Schroeder, K, Gontarewicz, A, Schaefer, R

“…H-rev107-1 is a growth inhibitory RAS target gene capable of suppressing anchorage independent growth in vitro and in vivo. Using a tumour tissue array with…”
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Discordant results obtained for different methods of HER-2/neu testing in breast cancer a question of standardization, automation and timing by Lftner, D., Henschke, P., Kafka, A., Anagnostopoulos, I., Wiechen, K., Geppert, R., Stein, H., Wernecke, K.D., Kreienberg, R., Possinger, K.

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Expression of gelsolin in ovarian carcinomas by Noske, A., Schober, H., Zhumabayeva, B., Sers, C., Denkert, C., Dietel, M., Wiechen, K.

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