Search Results - "Wieben, E D"

SLC6A4 variation and citalopram response by Mrazek, D.A., Rush, A.J., Biernacka, J.M., O'Kane, D.J., Cunningham, J.M., Wieben, E.D., Schaid, D.J., Drews, M.S., Courson, V.L., Snyder, K.A., Black III, J.L., Weinshilboum, R.M.

“…The influence of genetic variations in SLC6A4 (serotonin transporter gene) on citalopram treatment of depression using the Sequenced Treatment to Relieve…”
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Pharmacogenetics of the mycophenolic acid targets inosine monophosphate dehydrogenases IMPDH1 and IMPDH2: gene sequence variation and functional genomics by Wu, T‐Y, Peng, Y, Pelleymounter, LL, Moon, I, Eckloff, BW, Wieben, ED, Yee, VC, Weinshilboum, RM

“…BACKGROUND AND PURPOSE Inosine monophosphate dehydrogenases, encoded by IMPDH1 and IMPDH2, are targets for the important immunosuppressive drug, mycophenolic…”
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Human catechol O-methyltransferase genetic variation: gene resequencing and functional characterization of variant allozymes by SHIELD, A. J, THOMAE, B. A, ECKLOFF, B. W, WIEBEN, E. D, WEINSHILBOUM, R. M

“…Catechol O-methyltransferase (COMT) plays an important role in the metabolism of catecholamines, catecholestrogens and catechol drugs. A common COMT G472A…”
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Human cytosolic sulfotransferase database mining: identification of seven novel genes and pseudogenes by Freimuth, R R, Wiepert, M, Chute, C G, Wieben, E D, Weinshilboum, R M

“…A total of 10 SULT genes are presently known to be expressed in human tissues. We performed a comprehensive genome-wide search for novel SULT genes using two…”
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Genetic diversity and function in the human cytosolic sulfotransferases by Hildebrandt, M A T, Carrington, D P, Thomae, B A, Eckloff, B W, Schaid, D J, Yee, V C, Weinshilboum, R M, Wieben, E D

“…Amino-acid substitutions, which result from common nonsynonymous (NS) polymorphisms, may dramatically alter the function of the encoded protein. Gaining…”
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A prospective genome-wide study of prostate cancer metastases reveals association of wnt pathway activation and increased cell cycle proliferation with primary resistance to abiraterone acetate–prednisone by Wang, L., Dehm, S.M., Hillman, D.W., Sicotte, H., Tan, W., Gormley, M., Bhargava, V., Jimenez, R., Xie, F., Yin, P., Qin, S., Quevedo, F., Costello, B.A., Pitot, H.C., Ho, T., Bryce, A.H., Ye, Z., Li, Y., Eiken, P., Vedell, P.T., Barman, P., McMenomy, B.P., Atwell, T.D., Carlson, R.E., Ellingson, M., Eckloff, B.W., Qin, R., Ou, F., Hart, S.N., Huang, H., Jen, J., Wieben, E.D., Kalari, K.R., Weinshilboum, R.M., Wang, L., Kohli, M.

“…Genomic aberrations have been identified in metastatic castration-resistant prostate cancer (mCRPC), but molecular predictors of resistance to abiraterone…”
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Human sulfotransferase SULT2A1 pharmacogenetics: genotype-to-phenotype studies by THOMAE, B. A, ECKLOFF, B. W, FREIMUTH, R. R, WIEBEN, E. D, WEINSHILBOUM, R. M

“…SULT2A1 catalyzes the sulfate conjugation of dehydroepiandrosterone (DHEA) as well as other steroids. As a step toward pharmacogenetic studies, we have…”
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Human liver dehydroepiandrosterone sulfotransferase: molecular cloning and expression of cDNA by Otterness, D M, Wieben, E D, Wood, T C, Watson, W G, Madden, B J, McCormick, D J, Weinshilboum, R M

“…Sulfation is an important pathway in the metabolism of many hormones and drugs. Human liver contains at least three well characterized sulfotransferase (ST)…”
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Thiopurine methyltransferase pharmacogenetics. Cloning of human liver cDNA and a processed pseudogene on human chromosome 18q21.1 by Lee, D, Szumlanski, C, Houtman, J, Honchel, R, Rojas, K, Overhauser, J, Wieben, E D, Weinshilboum, R M

“…Thiopurine methyltransferase (TPMT) is a genetically polymorphic enzyme that catalyzes the S-methylation of thiopurine drugs such as 6-mercaptopurine. This…”
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Abnormal processing of the human cholecystokinin receptor gene in association with gallstones and obesity by Miller, L J, Holicky, E L, Ulrich, C D, Wieben, E D

“…Cholesterol gallstone disease and obesity are often associated and share the potential, yet unreported, common etiology of cholecystokinin (CCK) dysfunction…”
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Human thiopurine methyltransferase: molecular cloning and expression of T84 colon carcinoma cell cDNA by Honchel, R, Aksoy, I A, Szumlanski, C, Wood, T C, Otterness, D M, Wieben, E D, Weinshilboum, R M

“…Thiopurine methyltransferase (TPMT) catalyzes the S-methylation of thiopurine drugs such as 6-mercaptopurine. Levels of TPMT activity in human tissue are…”
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Overexpression of the erythrocyte plasma membrane Ca2+ pump in COS-1 cells by ADAMO, H. P, VERMA, A. K, SANDERS, M. A, HEIM, R, SALISBURY, J. L, WIEBEN, E. D, PENNISTON, J. T

“…A full-length cDNA corresponding to the hPMCA4 plasma membrane Ca2+ pump was assembled and expressed in COS-1 cells. The original sequence of hPMCA4 gave a…”
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Eukaryotic small ribonucleoproteins. Anti-La human autoantibodies react with U1 RNA-protein complexes by Madore, S J, Wieben, E D, Pederson, T

“…Anti-La sera from patients with autoimmune disorders precipitate a set of nuclear and cytoplasmic small RNA-protein complexes. Up to now, it has been thought…”
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Molecular diversity of neuronal-type calcium channels identified in small cell lung carcinoma by Oguro-Okano, M, Griesmann, G E, Wieben, E D, Slaymaker, S J, Snutch, T P, Lennon, V A

“…Using the polymerase chain reaction (PCR), we identified RNA transcripts for two distinct classes of neuronal-type voltage-gated Ca2+ channels (VGCC) in a…”
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Intracellular Site of U1 Small Nuclear RNA Processing and Ribonucleoprotein Assembly by Madore, Steven J., Wieben, Eric D., Pederson, Thoru

“…We have investigated the intracellular site and posttranscriptional immediacy of U1 small nuclear RNA processing and ribonucleoprotein (RNP) assembly in HeLa…”
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Human dehydroepiandrosterone sulfotransferase gene: molecular cloning and structural characterization by Otterness, D M, Her, C, Aksoy, S, Kimura, S, Wieben, E D, Weinshilboum, R M

“…Dehydroepiandrosterone sulfotransferase (DHEA ST) catalyzes the sulfate conjugation of DHEA and other steroids. From 20 to 25% of subjects are included in a…”
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Human histamine N-methyltransferase pharmacogenetics: cloning and expression of kidney cDNA by Girard, B, Otterness, D M, Wood, T C, Honchel, R, Wieben, E D, Weinshilboum, R M

“…Histamine N-methyltransferase (HNMT) catalyzes the NT-methylation of histamine. The level of HNMT activity in human red blood cells is controlled by a common…”
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cDNA Cloning of a Human Autoimmune Nuclear Ribonucleoprotein Antigen by Wieben, Eric D., Rohleder, Anne M., Nenninger, Joan M., Pederson, Thoru

“…Sera from patients with systemic lupus erythematosus and other autoimmune disorders contain antibodies against nuclear proteins. One such autoantibody system,…”
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Transcriptional regulation of the small nuclear ribonucleoprotein E protein gene. Identification of cis-acting sequences with homology to genes encoding ribosomal proteins by FAUTSCH, M. P, WIEBEN, E. D

“…The 5'-upstream region of the small nuclear ribonucleoprotein E protein (snRNP E) gene has multiple sequence similarities to elements found to be integral in…”
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Rapid regulation of c-myc protooncogene expression by progesterone in the avian oviduct by Fink, Karen L., Wieben, Eric D., Woloschak, Gayle E., Spelsberg, Thomas C.

“…The mRNA levels of genes known to be regulated by sex steroids are not altered until 1 hr or longer after steroid treatment, although the steroid receptor…”
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