Search Results - "Wiebel, Friedrich J"

Smoke-free Germany 2040: a discussion paper by Hanewinkel, Reiner, Morgenstern, Matthis, Isensee, Barbara, Wiebel, Friedrich J

“…A "smoke-free" society is assumed if less than 5 % of a population smoke. We predict when this goal could be reached in Germany. To reduce the proportion of…”
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Impairment of UDP-glucose dehydrogenase and glucuronidation activities in liver and small intestine of rat and guinea pig in vitro by piperine by Reen, R K, Jamwal, D S, Taneja, S C, Koul, J L, Dubey, R K, Wiebel, F J, Singh, J

“…The effects of piperine, a major ingredient of black pepper, on UDP-glucose dehydrogenase (UDP-GDH) and glucuronidation potentials of rat and guinea pig liver…”
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Expression of cytochromes P-450 in rat hepatoma cells: analysis by monoclonal antibodies specific for cytochromes P-450 from rat liver induced by 3-methylcholanthrene or phenobarbital by WIEBEL, F. J, SANG SHIN PARK, KIEFER, F, GELBOIN, H. V

“…We have studied the expression of aldrin eposidase (AE), 7-ethoxycoumarin-O-deethylase (ECDE), and aryl hydrocarbon (benzo[a]pyrene) hydroxylase (AHH) in nine…”
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Piperine inhibits aflatoxin B 1-induced cytotoxicity and genotoxicity in V79 Chinese hamster cells genetically engineered to express rat cytochrome P4502B1 by Reen, Rashmeet K., Wiebel, Friedrich J., Singh, Jaswant

“…We have investigated the potential of piperine for inhibiting the activity of cytochrome P4502B1 and protecting against aflatoxin B 1 (AFB 1) in V79MZr2B1…”
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Piperine inhibits aflatoxin B1-induced cytotoxicity and genotoxicity in V79 Chinese hamster cells genetically engineered to express rat cytochrome P4502B1 by Reen, R.K, Wiebel, F.J, Singh, J

“…We have investigated the potential of piperine for inhibiting the activity of cytochrome P4502B1 and protecting against aflatoxin B1 (AFB1) in V79MZr2B1 (r2B1)…”
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Enzyme induction in mammalian cells defective in 28S ribosomal RNA formation by WIEBEL, FRIEDRICH J, BADER, JOHN P, GELBOIN, HARRY V

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Establishment of a Simple Cleanup Procedure and Bioassay for Determining 2,3,7,8-Tetrachlorodibenzo-p-dioxin Toxicity Equivalents of Environmental Samples by Schwirzer, Siegfried M.G., Hofmaier, Andrea M., Kettrup, Antonius, Nerdinger, Per E., Schramm, Karl-Werner, Thoma, Heinz, Wegenke, Martin, Wiebel, Friedrich J.

“…The study was aimed at establishing a bioassay for the determination of 2,3,7,8-tetrachlorodibenzo-p-dioxin toxicity equivalents (TEQs) in environmental…”
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Piperine Impairs Cytochrome P4501A1 Activity by Direct Interaction with the Enzyme and Not by Down Regulation of CYP1A1 Gene Expression in the Rat Hepatoma 5L Cell Line by Reen, Rashmeet K., Roesch, Siegfried F., Kiefer, Franz, Wiebel, Friedrich J., Singh, Jaswant

“…Modulation of benzo(a)pyrene (BP) metabolism and regulation of CYP1A1 gene expression by piperine in 5L cells in culture was studied. Treatment of cultures…”
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Ribonucleic Acid Synthesis-dependent Induction of Aryl Hydrocarbon Hydroxylase in the Absence of Ribosomal Ribonucleic Acid Synthesis and Transfer by Wiebel, F J, Matthews, E J, Gelboin, H V

“…The microsomal enzyme system, aryl hydrocarbon (benzo-[a]pyrene) hydroxylase, is highly inducible by substrate in monolayer cultures of the mouse thymus-spleen…”
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Piperine, a major ingredient of black and long peppers, protects against AFB1-induced cytotoxicity and micronuclei formation in H4IIEC3 rat hepatoma cells by Singh, J, Reen, R K, Wiebel, F J

“…We studied the effect of piperine on the cytotoxicity and genotoxicity of aflatoxin B1 (AFB1) in rat hepatoma cells H4IIEC3/G-(H4IIE) using cellular growth and…”
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Stable expression of human cytochrome P450 1A1 cDNA in V79 Chinese hamster cells and metabolic activation of benzo[a]pyrene by Schmalix, W A, Mäser, H, Kiefer, F, Reen, R, Wiebel, F J, Gonzalez, F, Seidel, A, Glatt, H, Greim, H, Doehmer, J

“…A V79 Chinese hamster cell line stably expressing human cytochrome P450 1A1 (CYP1A1) was obtained by chromosomal integration of the human CYP1A1 cDNA under the…”
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Genetically engineered V79 Chinese hamster cells for stable expression of human cytochrome P450IA2 by Wölfel, C, Heinrich-Hirsch, B, Schulz-Schalge, T, Seidel, A, Frank, H, Ramp, U, Wächter, F, Wiebel, F J, Gonzalez, F, Greim, H

“…V79 Chinese hamster cells were genetically engineered for stable expression of human P450IA2. Full length cDNA, encoding human P450IA2, was inserted into an…”
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Arylamines Suppress Their Own Activation and That of Nitroarenes in V79 Chinese Hamster Cells by Competing for Acetyltransferases by Kiefer, Franz, Cumpelik, Olga, Reen, Rashmeet, Doehmer, Johannes, Wiebel, Friedrich J.

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Dexamethasone-mediated potentiation of P450IA1 induction in H4IIEC3/T hepatoma cells is dependent on a time-consuming process and associated with induction of the Ah receptor by Wiebel, F J, Cikryt, P

“…The synergistic effect of dexamethasone (DEX) and polycyclic aromatic hydrocarbons on the induction of cytochrome P450IA1 (P450IA1) was examined in H4IIEC3/T…”
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Toxicity of monocyclic and polycyclic nitroaromatic compounds in a panel of mammalian test cell lines by Perchermeier, M M, Kiefer, F, Wiebel, F J

“…The cytotoxicity of polycyclic and monocyclic nitroarenes was tested in cell lines V79/NH, H4IIEC3/G-, 5L and BWI-J, which are distinguished by their specific…”
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Monooxygenase and UDP-glucuronyltransferase activities in established cell cultures by Wiebel, Friedrich J., Singh, Jaswant

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Arylamines Suppress Their Own Activation and That of Nitroarenes in V79 Chinese Hamster Cells by Competing for Acetyltransferases by Kiefer, Franz, Cumpelik, Olga, Reen, Rashmeet, Doehmer, Johannes, Wiebel, Friedrich J.

“…The effect of 2-aminofluorene (2-AF) on the toxicity of 2-aminoanthracene (2-AA) and 1,6-dinitropyrene (1,6-DNP) was studied in N-acetyltransferase-proficient…”
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V79 Chinese hamster cells express cytochrome P-450 activity after simultaneous exposure to polycyclic aromatic hydrocarbons and aminophylline by Kiefer, F, Wiebel, F J

“…V79 Chinese hamster lung cells expressed low but significant aryl hydrocarbon hydroxylase activities when treated with an inducer of cytochrome P-450I, such as…”
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Mutagenicity, clastogenicity and cytotoxicity of procarcinogens in a rat hepatoma cell line competent for xenobiotic metabolism by Roscher, E, Wiebel, F J

“…The present studies were aimed at evaluating the suitability of the differentiated Reuber hepatoma cells H4IIEC3/G- for monitoring permanent damage to the DNA…”
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Aryl hydrocarbon (benzo[a]pyrene) hydroxylases in liver from rats of different age, sex and nutritional status. Distinction of two types by 7,8-benzoflavone by Wiebel, F J, Gelboin, H V

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