Search Results - "Widzowski, D"

Quetiapine and its metabolite norquetiapine: translation from in vitro pharmacology to in vivo efficacy in rodent models by Cross, A J, Widzowski, D, Maciag, C, Zacco, A, Hudzik, T, Liu, J, Nyberg, S, Wood, M W

“…Background and Purpose Quetiapine has a range of clinical activity distinct from other atypical antipsychotic drugs, demonstrating efficacy as monotherapy in…”
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PW01-27 - Translational pharmacology of quetiapine and norquetiapine: preclinical findings support multifunctional psychotropic properties by Nyberg, S, Widzowski, D

“…Objectives Clinical studies demonstrate that quetiapine is efficacious in schizophrenia, bipolar mania, bipolar depression, major depressive disorder, and…”
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P.2.d.012 Further characterization of norquetiapine and quetiapine in rodent models of antidepressant and anxiolytic action by Hudzik, T, Zhou, J, Brockel, B, Sutton, E, Maciag, C, Grimm, S, Zeller, Z, Widzowski, D

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P.2.h.006 Quetiapine's antidepressant properties: direct and indirect pharmacologic actions on norepinephrine and serotonin receptors by Goldstein, J, Christoph, G, Grimm, S, Liu, J, Widzowski, D, Brecher, M

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P.2.h.004 Anxiolytic effects of quetiapine in rat punished responding: mechanism of action and the role of D2 antagonism by Maciag, C, Smolka, J, McLaughlin, J, Hudzik, T, Evenden, J, Widzowski, D

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Low affinity use-dependent NMDA receptor antagonists show promise for clinical development by Palmer, G C, Widzowski, D

“…The success of the low affinity use-dependent NMDA receptor antagonists to reach clinical trials can be readily attributed to their wider margins of safety and…”
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Long-Term Functional End Points Following Middle Cerebral Artery Occlusion in the Rat by Hudzik, T.J, Borrelli, A, Bialobok, P, Widzowski, D, Sydserff, S, Howell, A, Gendron, P, Corbett, D, Miller, J, Palmer, G.C

“…The purpose of the present study was to assess the magnitude and stability of a number of functional deficits in rats subjected to occlusion of the middle…”
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Homogeneity of regional brain lead concentrations by Widzowski, D V, Cory-Slechta, D A

“…It has been proposed that the neurobiological basis of many of the behavioral manifestations arising in response to Pb exposure may be due to selective…”
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Apparent mediation of the stimulus properties of a low dose of quinpirole by dopaminergic autoreceptors by Widzowski, D V, Cory-Slechta, D A

“…This study examined the hypothesis that, if the stimulus properties of the D2 agonist quinpirole (QUIN) were mediated by autoreceptors, then pharmacological…”
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Time course of postnatal lead-induced changes in dopamine receptors and their relationship to changes in dopamine sensitivity by Widzowski, D V, Finkelstein, J N, Pokora, M J, Cory-Slechta, D A

“…Although alterations in dopaminergic function represent a potential neurochemical basis of Pb-induced behavioral deficits, the impact of postnatal Pb exposure…”
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Postnatal lead exposure induces supersensitivity to the stimulus properties of a D2-D3 agonist by Cory-Slechta, D A, Pokora, M J, Widzowski, D V

“…To examine the impact of lead (Pb) exposure during the ontogeny of dopaminergic (DA) systems on resultant DA function, rats were exposed postnatally (0-21 days…”
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Low level lead exposure increases sensitivity to the stimulus properties of dopamine D1 and D2 agonists by Cory-Slechta, D A, Widzowski, D V

“…To examine the impact of Pb exposure on dopaminergic (DA) function, weanling rats were chronically exposed to 0, 50 or 250 ppm Pb acetate in drinking water. At…”
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Functional alterations in dopamine systems assessed using drug discrimination procedures by Cory-Slechta, D A, Widzowski, D V, Pokora, M J

“…Numerous studies have suggested that Pb-induced perturbations of dopamine (DA) systems and DA functions could underlie the behavioral impairments attributed to…”
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Behavioral manifestations of prolonged lead exposure initiated at different stages of the life cycle: II. Delayed spatial alternation by Cory-Slechta, D A, Pokora, M J, Widzowski, D V

“…Since both Pb exposure and aging have been associated with alterations in memory functions, this study compared the effects of Pb exposure initiated at early,…”
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Behavioral differentiation of the stimulus properties of a dopaminergic D1 agonist from a D2 agonist by Cory-Slechta, D A, Widzowski, D V, Newland, M C

“…This study examined the hypothesis that the stimulus properties of a dopaminergic D1 agonist should be functionally discriminable from those of a D2 agonist…”
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Comparison of antidepressant and anxiolytic activity of quetiapine and its metabolite, norquetiapine, in rodent models by Maciag, C, Brockel, B, Smolka, J, McLaughlin, J, Duncan, B, Evenden, J, Hudzik, T, Widzowski, D

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Lead retards development of Drosophila melanogaster by Cohn, J, Widzowski, D V, Cory-Slechta, D A

“…1. Lead (Pb) is a ubiquitous environmental toxicant which has been reported to have growth-retarding effects. That premise was examined in the current study of…”
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Selective muscarinic M sub(1) antagonists: Drug design and discovery by Widzowski, D, Helander, H F, Wu, ESC

“…Years of clinical research to treat disorders such as peptic ulcers and obstructive lung disease with the first generation of modestly selective M sub(1)…”
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Selective muscarinic M 1 antagonists: drug design and discovery by Widzowski, Daniel, Wu, Edwin S.C., Helander, Herbert F.

“…Years of clinical research to treat disorders such as peptic ulcers and obstructive lung disease with the first generation of modestly selective M 1…”
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Selective muscarinic M1 antagonists : drug design and discovery by WIDZOWSKI, D, HELANDER, H. F, WU, E. S. C

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