Search Results - "Widholz, Sebastian A."

Non-canonical functions of SNAIL drive context-specific cancer progression by Paul, Mariel C., Schneeweis, Christian, Falcomatà, Chiara, Shan, Chuan, Rossmeisl, Daniel, Koutsouli, Stella, Klement, Christine, Zukowska, Magdalena, Widholz, Sebastian A., Jesinghaus, Moritz, Heuermann, Konstanze K., Engleitner, Thomas, Seidler, Barbara, Sleiman, Katia, Steiger, Katja, Tschurtschenthaler, Markus, Walter, Benjamin, Weidemann, Sören A., Pietsch, Regina, Schnieke, Angelika, Schmid, Roland M., Robles, Maria S., Andrieux, Geoffroy, Boerries, Melanie, Rad, Roland, Schneider, Günter, Saur, Dieter

“…SNAIL is a key transcriptional regulator in embryonic development and cancer. Its effects in physiology and disease are believed to be linked to its role as a…”
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Genome‐wide cooperation of EMT transcription factor ZEB1 with YAP and AP‐1 in breast cancer by Feldker, Nora, Ferrazzi, Fulvia, Schuhwerk, Harald, Widholz, Sebastian A, Guenther, Kerstin, Frisch, Isabell, Jakob, Kathrin, Kleemann, Julia, Riegel, Dania, Bönisch, Ulrike, Lukassen, Sören, Eccles, Rebecca L, Schmidl, Christian, Stemmler, Marc P, Brabletz, Thomas, Brabletz, Simone

“…Invasion, metastasis and therapy resistance are the major cause of cancer‐associated deaths, and the EMT‐inducing transcription factor ZEB1 is a crucial…”
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An integrated cellular and molecular model of gastric neuroendocrine cancer evolution highlights therapeutic targets by Griger, Joscha, Widholz, Sebastian A., Jesinghaus, Moritz, de Andrade Krätzig, Niklas, Lange, Sebastian, Engleitner, Thomas, Montero, Juan José, Zhigalova, Ekaterina, Öllinger, Rupert, Suresh, Veveeyan, Winkler, Wiebke, Lier, Svenja, Baranov, Olga, Trozzo, Riccardo, Ben Khaled, Najib, Chakraborty, Shounak, Yu, Jiakun, Konukiewitz, Björn, Steiger, Katja, Pfarr, Nicole, Rajput, Ashish, Sailer, David, Keller, Gisela, Schirmacher, Peter, Röcken, Christoph, Fagerstedt, Klaus W., Mayerle, Julia, Schmidt-Supprian, Marc, Schneider, Günter, Weichert, Wilko, Calado, Dinis P., Sommermann, Thomas, Klöppel, Günter, Rajewsky, Klaus, Saur, Dieter, Rad, Roland

“…Gastric neuroendocrine carcinomas (G-NEC) are aggressive malignancies with poorly understood biology and a lack of disease models. Here, we use genome…”
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Genetically Engineered Mouse Models of Liver Tumorigenesis Reveal a Wide Histological Spectrum of Neoplastic and Non-Neoplastic Liver Lesions by Steiger, Katja, Gross, Nina, Widholz, Sebastian A., Rad, Roland, Weichert, Wilko, Mogler, Carolin

“…Genetically engineered mouse models (GEMM) are an elegant tool to study liver carcinogenesis in vivo. Newly designed mouse models need detailed…”
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CRISPR somatic genome engineering and cancer modeling in the mouse pancreas and liver by Kaltenbacher, Thorsten, Löprich, Jessica, Maresch, Roman, Weber, Julia, Müller, Sebastian, Oellinger, Rupert, Groß, Nina, Griger, Joscha, de Andrade Krätzig, Niklas, Avramopoulos, Petros, Ramanujam, Deepak, Brummer, Sabine, Widholz, Sebastian A., Bärthel, Stefanie, Falcomatà, Chiara, Pfaus, Anja, Alnatsha, Ahmed, Mayerle, Julia, Schmidt-Supprian, Marc, Reichert, Maximilian, Schneider, Günter, Ehmer, Ursula, Braun, Christian J., Saur, Dieter, Engelhardt, Stefan, Rad, Roland

“…Genetically engineered mouse models (GEMMs) transformed the study of organismal disease phenotypes but are limited by their lengthy generation in embryonic…”
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Copy number variation of two separate regulatory regions upstream of SOX9 causes isolated 46,XY or 46,XX disorder of sex development by Kim, Gwang-Jin, Sock, Elisabeth, Buchberger, Astrid, Just, Walter, Denzer, Friederike, Hoepffner, Wolfgang, German, James, Cole, Trevor, Mann, Jillian, Seguin, John H, Zipf, William, Costigan, Colm, Schmiady, Hardi, Rostásy, Moritz, Kramer, Mildred, Kaltenbach, Simon, Rösler, Bernd, Georg, Ina, Troppmann, Elke, Teichmann, Anne-Christin, Salfelder, Anika, Widholz, Sebastian A, Wieacker, Peter, Hiort, Olaf, Camerino, Giovanna, Radi, Orietta, Wegner, Michael, Arnold, Hans-Henning, Scherer, Gerd

“…SOX9 mutations cause the skeletal malformation syndrome campomelic dysplasia in combination with XY sex reversal. Studies in mice indicate that SOX9 acts as a…”
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Selective multi-kinase inhibition sensitizes mesenchymal pancreatic cancer to immune checkpoint blockade by remodeling the tumor microenvironment by Falcomatà, Chiara, Bärthel, Stefanie, Widholz, Sebastian A, Schneeweis, Christian, Montero, Juan José, Toska, Albulena, Mir, Jonas, Kaltenbacher, Thorsten, Heetmeyer, Jeannine, Swietlik, Jonathan J, Cheng, Jing-Yuan, Teodorescu, Bianca, Reichert, Oliver, Schmitt, Constantin, Grabichler, Kathrin, Coluccio, Andrea, Boniolo, Fabio, Veltkamp, Christian, Zukowska, Magdalena, Vargas, Angelica Arenas, Paik, Woo Hyun, Jesinghaus, Moritz, Steiger, Katja, Maresch, Roman, Öllinger, Rupert, Ammon, Tim, Baranov, Olga, Robles, Maria S, Rechenberger, Julia, Kuster, Bernhard, Meissner, Felix, Reichert, Maximilian, Flossdorf, Michael, Rad, Roland, Schmidt-Supprian, Marc, Schneider, Günter, Saur, Dieter

“…KRAS-mutant pancreatic ductal adenocarcinoma (PDAC) is highly immunosuppressive and resistant to targeted and immunotherapies. Among the different PDAC…”
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TRAIL Receptor Targeting Agents Potentiate PARP Inhibitor Efficacy in Pancreatic Cancer Independently of BRCA2 Mutation Status by Ben Khaled, Najib, Hammer, Katharina, Ye, Liangtao, Alnatsha, Ahmed, Widholz, Sebastian A., Piseddu, Ignazio, Sirtl, Simon, Schneider, Julia, Munker, Stefan, Mahajan, Ujjwal Mukund, Montero, Juan José, Griger, Joscha, Mayerle, Julia, Reiter, Florian P., De Toni, Enrico N.

“…Chemotherapy, the standard treatment for pancreatic ductal adenocarcinoma (PDAC), has only a modest effect on the outcome of patients with late-stage disease…”
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Genome‐wide cooperation of EMT transcription factor ZEB 1 with YAP and AP ‐1 in breast cancer by Feldker, Nora, Ferrazzi, Fulvia, Schuhwerk, Harald, Widholz, Sebastian A, Guenther, Kerstin, Frisch, Isabell, Jakob, Kathrin, Kleemann, Julia, Riegel, Dania, Bönisch, Ulrike, Lukassen, Sören, Eccles, Rebecca L, Schmidl, Christian, Stemmler, Marc P, Brabletz, Thomas, Brabletz, Simone

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TRAIL Receptor Targeting Agents Potentiate PARP Inhibitor Efficacy in Pancreatic Cancer Independently of IBRCA2/I Mutation Status by Ben Khaled, Najib, Hammer, Katharina, Ye, Liangtao, Alnatsha, Ahmed, Widholz, Sebastian A, Piseddu, Ignazio, Sirtl, Simon, Schneider, Julia, Munker, Stefan, Mahajan, Ujjwal Mukund, Montero, Juan José, Griger, Joscha, Mayerle, Julia, Reiter, Florian P, De Toni, Enrico N

“…Research into pancreatic cancer has identified frequent changes in BRCA genes, especially in BRCA2, occurring in about 5% of patients. BRCA proteins help…”
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Abstract 2514: Pancreatic cancer subtype-specific secreted factors determine the immunosuppressive tumor microenvironment by Bärthel, Stefanie, Falcomatà, Chiara, Widholz, Sebastian A., Toska, Albulena, Boniolo, Fabio, Schmitt, Constantin, Gölling, Vanessa, Swietlik, Jonathan, Mir, Jonas, Jesinghaus, Moritz, Meissner, Felix, Rad, Roland, Schmidt-Supprian, Marc, Saur, Dieter

“…Pancreatic ductal adenocarcinoma (PDAC) is a complex disease displaying genetic heterogeneity along with a tumor microenvironment (TME) unique in its…”
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