Search Results - "Wideman, Jeremy G"
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A new mitofusin topology places the redox-regulated C terminus in the mitochondrial intermembrane space
Published in The Journal of cell biology (05-02-2018)“…Mitochondrial fusion occurs in many eukaryotes, including animals, plants, and fungi. It is essential for cellular homeostasis, and yet the underlying…”
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The ubiquitous and ancient ER membrane protein complex (EMC): tether or not?
Published in F1000 research (2015)“…The recently discovered endoplasmic reticulum (ER) membrane protein complex (EMC) has been implicated in ER-associated degradation (ERAD), lipid transport and…”
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Mitochondrial genomes revisited: why do different lineages retain different genes?
Published in BMC biology (25-01-2024)“…The mitochondria contain their own genome derived from an alphaproteobacterial endosymbiont. From thousands of protein-coding genes originally encoded by their…”
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Ancient Homology of the Mitochondrial Contact Site and Cristae Organizing System Points to an Endosymbiotic Origin of Mitochondrial Cristae
Published in Current biology (01-06-2015)“…Mitochondria are eukaryotic organelles that originated from an endosymbiotic α-proteobacterium. As an adaptation to maximize ATP production through oxidative…”
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Losing Complexity: The Role of Simplification in Macroevolution
Published in Trends in ecology & evolution (Amsterdam) (01-08-2016)“…Macroevolutionary patterns can be produced by combinations of diverse and even oppositional dynamics. A growing body of data indicates that secondary…”
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Single cell genomics reveals plastid-lacking Picozoa are close relatives of red algae
Published in Nature communications (17-11-2021)“…The endosymbiotic origin of plastids from cyanobacteria gave eukaryotes photosynthetic capabilities and launched the diversification of countless forms of…”
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The evolution of ERMIONE in mitochondrial biogenesis and lipid homeostasis: An evolutionary view from comparative cell biology
Published in Biochimica et biophysica acta (01-08-2016)“…The ER–mitochondria organizing network (ERMIONE) in Saccharomyces cerevisiae is involved in maintaining mitochondrial morphology and lipid homeostasis. ERMES…”
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Cell Biology: Functional Conservation, Structural Divergence, and Surprising Convergence in the MICOS Complex of Trypanosomes
Published in Current biology (05-11-2018)“…The MICOS complex is conserved across eukaryotes, but little is known about it outside the group that comprises animals and fungi. A new study finds that…”
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The persistent homology of mitochondrial ATP synthases
Published in iScience (19-05-2023)“…Relatively little is known about ATP synthase structure in protists, and the investigated ones exhibit divergent structures distinct from yeast or animals. To…”
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A functional bacteria-derived restriction modification system in the mitochondrion of a heterotrophic protist
Published in PLoS biology (23-04-2021)“…The overarching trend in mitochondrial genome evolution is functional streamlining coupled with gene loss. Therefore, gene acquisition by mitochondria is…”
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The ancient and widespread nature of the ER-mitochondria encounter structure
Published in Molecular biology and evolution (01-09-2013)“…Mitochondria are the result of a billion years of integrative evolution, converting a once free-living bacterium to an organelle deeply linked to diverse…”
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What Defines the "Kingdom" Fungi?
Published in Microbiology spectrum (01-06-2017)“…The application of environmental DNA techniques and increased genome sequencing of microbial diversity, combined with detailed study of cellular characters,…”
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Single-cell genomics unveils a canonical origin of the diverse mitochondrial genomes of euglenozoans
Published in BMC biology (17-05-2021)“…The supergroup Euglenozoa unites heterotrophic flagellates from three major clades, kinetoplastids, diplonemids, and euglenids, each of which exhibits…”
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First report of mitochondrial COI in foraminifera and implications for DNA barcoding
Published in Scientific reports (12-11-2021)“…Foraminifera are a species-rich phylum of rhizarian protists that are highly abundant in many marine environments and play a major role in global carbon…”
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A single-cell genome reveals diplonemid-like ancestry of kinetoplastid mitochondrial gene structure
Published in Philosophical transactions of the Royal Society of London. Series B. Biological sciences (07-10-2019)“…Euglenozoa comprises euglenids, kinetoplastids, and diplonemids, with each group exhibiting different and highly unusual mitochondrial genome organizations…”
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Homologue replacement in the import motor of the mitochondrial inner membrane of trypanosomes
Published in eLife (27-02-2020)“…Many mitochondrial proteins contain N-terminal presequences that direct them to the organelle. The main driving force for their translocation across the inner…”
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Single-Cell Genomics Reveals the Divergent Mitochondrial Genomes of Retaria (Foraminifera and Radiolaria)
Published in mBio (25-04-2023)“…Mitochondria originated from an ancient bacterial endosymbiont that underwent reductive evolution by gene loss and endosymbiont gene transfer to the nuclear…”
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Evolutionary conservation of a core fungal phosphate homeostasis pathway coupled to development in Blastocladiella emersonii
Published in Fungal genetics and biology (01-06-2018)“…•PHO response pathway of Saccharomyces cerevisiae is largely conserved in all major fungal lineages.•Conserved transcriptional response to phosphate limitation…”
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Concepts of the last eukaryotic common ancestor
Published in Nature ecology & evolution (01-03-2019)“…Insight into the last eukaryotic common ancestor (LECA) is central to any phylogeny-based reconstruction of early eukaryotic evolution. Increasing amounts of…”
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The Evolutionary History of MAPL (Mitochondria-Associated Protein Ligase) and Other Eukaryotic BAM/GIDE Domain Proteins
Published in PloS one (05-06-2015)“…MAPL (mitochondria-associated protein ligase, also called MULAN/GIDE/MUL1) is a multifunctional mitochondrial outer membrane protein found in human cells that…”
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