Search Results - "Wideburg, Norman"

Discovery of Ritonavir, a Potent Inhibitor of HIV Protease with High Oral Bioavailability and Clinical Efficacy by Kempf, Dale J, Sham, Hing L, Marsh, Kennan C, Flentge, Charles A, Betebenner, David, Green, Brian E, McDonald, Edith, Vasavanonda, Sudthida, Saldivar, Ayda, Wideburg, Norman E, Kati, Warren M, Ruiz, Lisa, Zhao, Chen, Fino, LynnMarie, Patterson, Jean, Molla, Akhteruzzaman, Plattner, Jacob J, Norbeck, Daniel W

“…The structure−activity studies leading to the potent and clinically efficacious HIV protease inhibitor ritonavir are described. Beginning with the moderately…”
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Synthesis and SAR studies of potent HIV protease inhibitors containing novel dimethylphenoxyl acetates as P2 ligands by XIAOQI CHEN, KEMPF, Dale J, LIN LI, SHAM, Hing L, VASAVANONDA, Sudthida, WIDEBURG, Norman E, SALDIVAR, Ayda, MARSH, Kennan C, MCDONALD, Edith, NORBECK, Daniel W

“…Isopropyl substituted 4-thioazolyl valine side chains are highly optimized P(2)-P(3) ligands for C2 symmetry-based HIV protease inhibitors, as exemplified by…”
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Influence of stereochemistry on activity and binding modes for C2 symmetry-based diol inhibitors of HIV-1 protease by Hosur, Madhusoodan V, Bhat, T. Narayana, Kempf, Dale J, Baldwin, Eric T, Liu, Beishan, Gulnik, Sergei, Wideburg, Norman E, Norbeck, Daniel W, Appelt, Krzysztof, Erickson, John W

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Symmetry-based inhibitors of HIV protease. Structure-activity studies of acylated 2,4-diamino-1,5-diphenyl-3-hydroxypentane and 2,5-diamino-1,6-diphenylhexane-3,4-diol by Kempf, Dale J, Codacovi, Lynnmarie, Wang, Xiu Chun, Kohlbrenner, William E, Wideburg, Norman E, Saldivar, Ayda, Vasavanonda, Sudthida, Marsh, Kennan C, Bryant, Pamela

“…The structure-activity relationships in two series of novel, symmetry-based inhibitors of HIV protease, the enzyme responsible for maturation of the human…”
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A Novel, Picomolar Inhibitor of Human Immunodeficiency Virus Type 1 Protease by Sham, Hing L, Zhao, Chen, Stewart, Kent D, Betebenner, David A, Lin, Shuqun, Park, Chang H, Kong, Xiang-P, Rosenbrook, William, Herrin, Thomas, Madigan, Darold, Vasavanonda, Suthida, Lyons, Nicholas, Molla, Akhter, Saldivar, Ayda, Marsh, Kennan C, McDonald, Edith, Wideburg, Norman E, Denissen, Jon F, Robins, Terrel, Kempf, Dale J, Plattner, Jacob J, Norbeck, Daniel W

“…The design, synthesis, and molecular modeling studies of a novel series of azacyclic ureas, which are inhibitors of human immunodeficiency virus type 1 (HIV-1)…”
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Synthesis and SAR studies of potent HIV protease inhibitors containing novel dimethylphenoxyl acetates as P 2 ligands by Chen, Xiaoqi, Kempf, Dale J., Li, Lin, Sham, Hing L., Vasavanonda, Sudthida, Wideburg, Norman E., Saldivar, Ayda, Marsh, Kennan C., McDonald, Edith, Norbeck, Daniel W.

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ABT-538 is a Potent Inhibitor of Human Immunodeficiency Virus Protease and has High Oral Bioavailability in Humans by Kempf, Dale J., Marsh, Kennan C., Denissen, Jon F., McDonald, Edith, Vasavanonda, Sudthida, Flentge, Charles A., Green, Brian E., Fino, Lynnmarie, Park, Chang H., Kong, Xiang-Peng, Wideburg, Norman E., Saldivar, Ayda, Ruiz, Lisa, Kati, Warren M., Sham, Hing L., Robins, Terry, Stewart, Kent D., Hsu, Ann, Plattner, Jacob J., Leonard, John M., Norbeck, Daniel W.

“…Examination of the structural basis for antiviral activity, oral pharmacokinetics, and hepatic metabolism among a series of symmetry-based inhibitors of the…”
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Structure-based, C2 symmetric inhibitors of HIV protease by Kempf, Dale J, Norbeck, Daniel W, Codacovi, LynnMarie, Wang, Xiu Chun, Kohlbrenner, William E, Wideburg, Norman E, Paul, Deborah A, Knigge, Mark F, Vasavanonda, Sudthida

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Characterization of human immunodeficiency virus type 1 variants with increased resistance to a C2-symmetric protease inhibitor by HO, D. D, TOYOSHIMA, T, HONGMEI MO, KEMPF, D. J, NORBECK, D, CHIH-MING CHEN, WIDEBURG, N. E, BURT, S. K, ERICKSON, J. W, SINGH, M. K

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Design, activity, and 2.8 A crystal structure of a C2 symmetric inhibitor complexed to HIV-1 protease by Erickson, J, Neidhart, D J, VanDrie, J, Kempf, D J, Wang, X C, Norbeck, D W, Plattner, J J, Rittenhouse, J W, Turon, M, Wideburg, N

“…A two-fold (C2) symmetric inhibitor of the protease of human immunodeficiency virus type-1 (HIV-1) has been designed on the basis of the three-dimensional…”
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Synthetic chemical diversity: solid phase synthesis of libraries of C2 symmetric inhibitors of HIV protease containing diamino diol and diamino alcohol cores by Wang, Gary T, Li, Sam, Wideburg, Norman, Krafft, Grant A, Kempf, Dale J

“…Solid phase synthesis of non-oligomeric organic compounds has been pursued for high-efficiency generation of large numbers of structurally diverse compounds…”
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A new aminoglycoside antibiotic complex--the seldomycins. IV. The structure of seldomycin factor 5 by McAlpine, J B, Sinclair, A C, Egan, R S, De Vault, R L, Stanaseszek, R S, Cirovic, M, Mueller, S L, Goodley, P C, Mauritz, R J, Wideburg, N E, Mitscher, L A, Shirahata, K, Matsushima, H, Sato, S, Iida, T

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Evaluation of furofuran as a P2 ligand for symmetry-based HIV protease inhibitors by Chen, Xiaoqi, Li, Lin, Kempf, Dale J., Sham, Hing, Wideburg, Norman E., Saldivar, Ayda, Vasavanonda, Sudthida, Marsh, Kennan C., McDonald, Edith, Norbeck, Daniel W.

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Design of orally bioavailable, symmetry-based inhibitors of HIV protease by Kempf, D J, Marsh, K C, Fino, L C, Bryant, P, Craig-Kennard, A, Sham, H L, Zhao, C, Vasavanonda, S, Kohlbrenner, W E, Wideburg, N E

“…A series of novel inhibitors of HIV-1 protease with excellent oral bioavailability is described. Differential acylation of the two amino groups of…”
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Potent piperazine hydroxyethylamine HIV protease inhibitors containing novel P 3 ligands by Chen, Xiaoqi, Kempf, Dale J., Sham, Hing L., Green, Brian E., Molla, Akhteruzaman, Korneyeva, Marina, Vasavanonda, Sudthida, Wideburg, Norman E., Saldivar, Ayda, Marsh, Kennan C., McDonald, Edith, Norbeck, Daniel W.

“…The 2-isopropyl thiazolyl group is a highly optimized P 3 ligand for C 2 symmetry-based HIV protease inhibitors, as exemplified in the drug ritonavir. Here we…”
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Potent piperazine hydroxyethylamine HIV protease inhibitors containing novel p3 ligands by XIAOQI CHEN, KEMPF, D. J, MCDONALD, E, NORBECK, D. W, SHAM, H. L, GREEN, B. E, MOLLA, A, KORNEYEVA, M, VASAVANONDA, S, WIDEBURG, N. E, SALDIVAR, A, MARSH, K. C

“…The 2-isopropyl thiazolyl group is a highly optimized P3 ligand for C2 symmetry-based HIV protease inhibitors, as exemplified in the drug ritonavir. Here we…”
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Evaluation of substituted benzamides as P2 ligands for symmetry-based inhibitors of HIV protease by Kempf, Dale J., Flentge, Charles A., Wideburg, Norman E., Saldivar, Ayda, Vasavanonda, Sudthida, Norbeck, Daniel W.

“…Substituted benzamides were evaluated as P2 ligands for symmetry-based HIV protease inhibitors. In contrast to previous reports, 2-methyl substitution provided…”
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Evaluation of furofuran as a P 2 ligand for symmetry-based HIV protease inhibitors by Chen, Xiaoqi, Li, Lin, Kempf, Dale J., Sham, Hing, Wideburg, Norman E., Saldivar, Ayda, Vasavanonda, Sudthida, Marsh, Kennan C., McDonald, Edith, Norbeck, Daniel W.

“…The hexahydrofurofuranyloxy group was evaluated as a conformationally constrained P 2 ligand for symmetry-based HIV protease inhibitors. A number of compounds…”
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Novel Azacyclic Ureas That Are Potent Inhibitors of HIV-1 Protease by Sham, Hing L., Zhao, Chen, Marsh, Kennan C., Betebenner, David A., Lin, Shuqun, Jr, William Rosenbrook, Herrin, Thomas, Li, Leping, Madigan, Darold, Vasavanonda, Suthida, Molla, Akhter, Saldivar, Ayda, McDonald, Edith, Wideburg, Norman E., Kempf, Dale, Norbeck, Daniel W., Plattner, Jacob J.

“…A series of novel, azacyclic ureas which are highly potent inhibitors of the HIV-1 protease (IC50= 4.1 to <0.5 nM) were synthesized. Aqueous solubilities of…”
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Potent Inhibitors of the HIV-1 Protease with Good Oral Bioavailabilities by Sham, H.L., Zhao, C., Marsh, K.C., Betebenner, D.A., Lin, S.Q., Mcdonald, E., Vasavanonda, S., Wideburg, N., Saldivar, A., Robins, T., Kempf, D.J., Plattner, J.J., Norbeck, D.W.

“…A series of novel pseudo-symmetrical and unsymmetrical inhibitors based on the backbone modification of a peptidomimetic were synthesized and found to be…”
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