Search Results - "Widdowson, P S"

Glucokinase activator PSN-GK1 displays enhanced antihyperglycaemic and insulinotropic actions by Fyfe, M. C. T, White, J. R, Taylor, A, Chatfield, R, Wargent, E, Printz, R. L, Sulpice, T, McCormack, J. G, Procter, M. J, Reynet, C, Widdowson, P. S, Wong-Kai-In, P

“…Aims/hypothesis We evaluated the insulinotropic and antihyperglycaemic actions of glucokinase activators (GKAs), especially through acute and subchronic…”
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Hypothalamic orexin expression: modulation by blood glucose and feeding by CAI, X. J, WIDDOWSON, P. S, HARROLD, J, WILSON, S, BUCKINGHAM, R. E, ARCH, J. R. S, TADAYYON, M, CLAPHAM, J. C, WILDING, J, WILLIAMS, G

“…Hypothalamic orexin expression: modulation by blood glucose and feeding. X J Cai , P S Widdowson , J Harrold , S Wilson , R E Buckingham , J R Arch , M…”
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Therapeutic index for rosiglitazone in dietary obese rats: separation of efficacy and haemodilution by Pickavance, L C, Tadayyon, M, Widdowson, P S, Buckingham, R E, Wilding, J P H

“…The blood glucose‐lowering efficacy of rosiglitazone (RSG) and the mechanisms of associated weight gain were determined in dietary obese rats (DIOs). DIO and…”
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Inhibition of food response to intracerebroventricular injection of leptin is attenuated in rats with diet-induced obesity by WIDDOWSON, P. S, UPTON, R, BUCKINGHAM, R, ARCH, J, WILLIAMS, G

“…The fat-derived hormone, leptin, is thought to regulate adipose tissue mass by acting on the brain to reduce food intake and increase thermogenesis. We have…”
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Inhibition of food response to intracerebroventricular injection of leptin is attenuated in rats with diet-induced obesity by Widdowson, P. S., Upton, R., Buckingham, R., Arch, J., Williams, G.

“…Inhibition of food response to intracerebroventricular injection of leptin is attenuated in rats with diet-induced obesity. P S Widdowson , R Upton , R…”
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Altered energy balance causes selective changes in melanocortin-4(MC4-R), but not melanocortin-3 (MC3-R), receptors in specific hypothalamic regions: further evidence that activation of MC4-R is a physiological inhibitor of feeding by HARROLD, J. A, WIDDOWSON, P. S, WILLIAMS, G

“…Altered energy balance causes selective changes in melanocortin-4(MC4-R), but not melanocortin-3 (MC3-R), receptors in specific hypothalamic regions: further…”
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Improved metabolic status and insulin sensitivity in obese fatty (fa/fa) Zucker rats and Zucker Diabetic Fatty (ZDF) rats treated with the thiazolidinedione, MCC‐555 by Upton, R, Widdowson, P. S., Ishii, S, Tanaka, H, Williams, G

“…We examined the effect of chronic (21 days) oral treatment with the thiazolidinedione, MCC‐555…”
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The development of overt diabetes in young Zucker Diabetic Fatty (ZDF) rats and the effects of chronic MCC‐555 treatment by Pickavance, L, Widdowson, P S, King, P, Ishii, S, Tanaka, H, Williams, G

“…1 Young (6‐week‐old) pre‐diabetic Zucker Diabetic Fatty (ZDF) rats displaying impaired glucose tolerance (IGT), moderate hyperglycaemia and hyperinsulinaemia…”
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Regulation of Neuropeptide Y Release by Neuropeptide Y Receptor Ligands and Calcium Channel Antagonists in Hypothalamic Slices by King, Peter J., Widdowson, Peter S., Doods, Henri N., Williams, Gareth

“…: Neuropeptide Y (NPY) is an important regulator of energy balance in mammals through its orexigenic, antithermogenic, and insulin secretagogue actions. We…”
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Quantitative receptor autoradiography demonstrates a differential distribution of neuropeptide-Y Y1 and Y2 receptor subtypes in human and rat brain by Widdowson, P S

“…Quantitative receptor autoradiography was performed on sections of rat and human brain using [125I]peptide YY ([125I]PYY) to measure the anatomical…”
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Regionally-selective down-regulation of NPY receptor subtypes in the obese Zucker rat. Relationship to the Y5 ‘feeding’ receptor by Widdowson, P.S.

“…Experiments were performed to examine whether there are regionally and subtype selective changes in the density of neuropeptide Y (NPY) receptors in the obese…”
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Reciprocal regional changes in brain NPY receptor density during dietary restriction and dietary-induced obesity in the rat by Widdowson, P.S, Upton, R, Henderson, L, Buckingham, R, Wilson, S, Williams, G

“…Neuropeptide Y (NPY) potently induces feeding, reduces thermogenesis and induces obesity in rats when injected into the cerebral ventricles. Groups of male…”
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Early Leptin Response to a Palatable Diet Predicts Dietary Obesity in Rats: Key Role of Melanocortin‐4 Receptors in the Ventromedial Hypothalamic Nucleus by Harrold, Joanne A., Williams, Gareth, Widdowson, Peter S.

“…We have investigated whether interactions between leptin and hypothalamic melanocortin‐4 receptors (MC4‐Rs) determine individual susceptibility to dietary…”
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Reduced neuropeptide Y concentrations in suicide brain by Widdowson, P S, Ordway, G A, Halaris, A E

“…Neuropeptide Y (NPY) was measured in postmortem brain tissue from victims of suicide and from individuals dying a sudden natural or accidental death…”
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Influence of age on the passage of paraquat through the blood-brain barrier in rats: a distribution and pathological examination by Widdowson, P S, Farnworth, M J, Simpson, M G, Lock, E A

“…Experiments were performed to determine the extent of paraquat entry into the brain of neonatal and elderly rats, as compared with adult rats, which may be…”
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No changes in behaviour, nigro-striatal system neurochemistry or neuronal cell death following toxic multiple oral paraquat administration to rats by Widdowson, P S, Farnworth, M J, Upton, R, Simpson, M G

“…We have examined whether the widely used herbicide, paraquat (1,1'-dimethyl-4,4'dipyridylium) may accumulate in rat brain following multiple oral dosing (5 mg…”
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Neuropathological Studies on Cycloate-Induced Neuronal Cell Death in the Rat Brain by Simpson, M.G., Horner, S.A., Mistry, P., Duffel, S., Widdowson, P.S., Scanlon, Y., Lock, E.A.

“…The herbicide cycloate (carbamothioic acid, ethyl(cyclohexyl)- S-ethyl ester) given as a single oral dose to rats, caused selective neuronal cell death in two…”
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NMDA receptors in rat cerebellum and forebrain: subtle differences in pharmacology and modulation by Widdowson, P S, Trainor, A, Lock, E A

“…Binding of [3H]glutamate, [3H]glycine, and the glutamate antagonist [3H]CGS-19755 to NMDA-type glutamate receptors was examined in homogenates of rat forebrain…”
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Existence of three subtypes of bradykinin B2 receptors in guinea pig by Seguin, L, Widdowson, P S, Giesen-Crouse, E

“…We describe the binding of [3H]bradykinin to homogenates of guinea pig brain, lung, and ileum. Analysis of [3H]bradykinin binding kinetics in guinea pig brain,…”
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Calpain activation and not oxidative damage mediates L-2-chloropropionic acid-induced cerebellar granule cell necrosis by WIDDOWSON, P. S, GYTE, A, UPTON, R, FOSTER, J, COUTTS, C. T, WYATT, I

“…Possible biochemical events involved in L-2-chloropropionic acid (L-CPA)-induced delayed cerebellar granule cell necrosis following N-methyl-D-aspartate…”
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