Search Results - "Wiczling, Pawel"

Comparison of Chromatographic Stationary Phases Using a Bayesian-Based Multilevel Model by Wiczling, Paweł, Kamedulska, Agnieszka

“…Herein, we used a Bayesian multilevel model of chromatographic retention to compare five reversed-phase high-performance liquid chromatography stationary…”
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Analyzing chromatographic data using multilevel modeling by Wiczling, Paweł

“…It is relatively easy to collect chromatographic measurements for a large number of analytes, especially with gradient chromatographic methods coupled with…”
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Application of Bayesian Multilevel Modeling in the Quantitative Structure–Retention Relationship Studies of Heterogeneous Compounds by Wiczling, Paweł, Kamedulska, Agnieszka, Kubik, Łukasz

“…Quantitative structure–retention relationships (QSRRs) are used in the field of chromatography to model the relationship between an analyte structure and…”
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Statistical analysis of isocratic chromatographic data using Bayesian modeling by Kamedulska, Agnieszka, Kubik, Łukasz, Wiczling, Paweł

“…Chromatographic retention times are usually modeled considering only one analyte at a time. However, it has certain limitations as no information is shared…”
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How Much Can We Learn from a Single Chromatographic Experiment? A Bayesian Perspective by Wiczling, Paweł, Kaliszan, Roman

“…In this work, we proposed and investigated a Bayesian inference procedure to find the desired chromatographic conditions based on known analyte properties…”
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Overview of experimental and computational methods for the determination of the pKa values of 5-fluorouracil, cyclophosphamide, ifosfamide, imatinib and methotrexate by Mioduszewska, Katarzyna, Dołżonek, Joanna, Wyrzykowski, Dariusz, Kubik, Łukasz, Wiczling, Paweł, Sikorska, Celina, Toński, Michał, Kaczyński, Zbigniew, Stepnowski, Piotr, Białk-Bielińska, Anna

“…We present a review of the available literature concerning pKa values and methods for the determination of selected anticancer drugs as well as the most…”
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Evaluation of sequential Bayesian‐based method development procedures for chromatographic problems involving one, two, and three analytes by Wiczling, Paweł

“…In this work, various sequential Bayesian‐based method development procedures associated with a search of isocratic chromatographic conditions ensuring…”
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Quantitative structure-(chromatographic) retention relationship models for dissociating compounds by Kubik, Łukasz, Wiczling, Paweł

“…The aim of this work was to develop mathematical models relating the hydrophobicity and dissociation constant of an analyte with its structure, which would be…”
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Maximum A Posteriori Bayesian Estimation of Chromatographic Parameters by Limited Number of Experiments by Wiczling, Paweł, Kubik, Łukasz, Kaliszan, Roman

“…The aim of this work was to develop a nonlinear mixed-effect chromatographic model able to describe the retention times of weak acids and bases in all possible…”
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Toward the General Mechanistic Model of Liquid Chromatographic Retention by Kamedulska, Agnieszka, Kubik, Łukasz, Jacyna, Julia, Struck-Lewicka, Wiktoria, Markuszewski, Michał J., Wiczling, Paweł

“…Large datasets of chromatographic retention times are relatively easy to collect. This statement is particularly true when mixtures of compounds are analyzed…”
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Targeted quantitative metabolomics with a linear mixed-effect model for analysis of urinary nucleosides and deoxynucleosides from bladder cancer patients before and after tumor resection by Artymowicz, Małgorzata, Struck-Lewicka, Wiktoria, Wiczling, Paweł, Markuszewski, Marcin, Markuszewski, Michał J., Siluk, Danuta

“…In the present study, we developed and validated a fast, simple, and sensitive quantitative method for the simultaneous determination of eleven nucleosides and…”
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Population Pharmacokinetics and Probability of Target Attainment Analysis of Nadroparin in Different Stages of COVID-19 by Piwowarczyk, Paweł, Szczukocka, Marta, Cios, Wojciech, Okuńska, Paulina, Raszewski, Grzegorz, Borys, Michał, Wiczling, Paweł, Czuczwar, Mirosław

“…Background and Objective The risk of thrombotic complications in critical patients with COVID-19 remains extremely high, and multicenter trials failed to prove…”
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Analysis of Isocratic-Chromatographic-Retention Data using Bayesian Multilevel Modeling by Kubik, Łukasz, Kaliszan, Roman, Wiczling, Paweł

“…The objective of this work was to develop a multilevel (hierarchical) model based on isocratic-reversed-phase-high-performance-chromatographic data collected…”
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Simultaneous determination of hydrophobicity and dissociation constant for a large set of compounds by gradient reverse phase high performance liquid chromatography–mass spectrometry technique by Kubik, Łukasz, Struck-Lewicka, Wiktoria, Kaliszan, Roman, Wiczling, Paweł

“…•The method of log P and pKa determination was tested on a large set of analytes.•It achieved a medium-throughput screening rate of 100 compounds per…”
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Population Pharmacokinetics of High-Dose Tigecycline in Patients with Sepsis or Septic Shock by Borsuk-De Moor, Agnieszka, Rypulak, Elżbieta, Potręć, Beata, Piwowarczyk, Paweł, Borys, Michał, Sysiak, Justyna, Onichimowski, Dariusz, Raszewski, Grzegorz, Czuczwar, Mirosław, Wiczling, Paweł

“…Tigecycline is a glycylcycline often used in critically ill patients as the antibiotic of last resort. The pharmacokinetics (PK) of tigecycline in intensive…”
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Nonstationary Pharmacokinetics of Caspofungin in ICU Patients by Borsuk-De Moor, Agnieszka, Sysiak-Sławecka, Justyna, Rypulak, Elżbieta, Borys, Michał, Piwowarczyk, Paweł, Raszewski, Grzegorz, Onichimowski, Dariusz, Czuczwar, Mirosław, Wiczling, Paweł

“…Standard dosing of caspofungin in critically ill patients has been reported to result in lower drug exposure, which can lead to subtherapeutic 24-h area under…”
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Bayesian multilevel model of micro RNA levels in ovarian-cancer and healthy subjects by Wiczling, Paweł, Daghir-Wojtkowiak, Emilia, Kaliszan, Roman, Markuszewski, Michał Jan, Limon, Janusz, Koczkowska, Magdalena, Stukan, Maciej, Kuźniacka, Alina, Ratajska, Magdalena

“…In transcriptomics, micro RNAs (miRNAs) has gained much interest especially as potential disease indicators. However, apart from holding a great promise…”
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pH Gradient as a Tool for the Separation of Ionizable Analytes in Reversed-Phase High-Performance Chromatography by Wiczling, Paweł, Kaliszan, Roman

“…The aim of this work was to propose a general scheme of optimizing separation of ionizable analytes and to determine conditions of maximal peak compression in…”
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pH-Gradient Liquid Chromatography: Fundamentals and Examples by Kubik, Łukasz, Wiczling, Paweł, Kaliszan, Roman

“…In this paper, we acquaint the readers with the fundamentals of gradient separation, followed by the latest innovations in this field. We describe the…”
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Gradient reversed-phase high-performance chromatography of ionogenic analytes by Kaliszan, Roman, Wiczling, Paweł

“…This review highlights the basis of gradient reversed-phase high-performance liquid chromatography (RP-HPLC) of ionogenic analytes. We describe pH-gradient…”
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