Search Results - "Wictorin, K"

Memantine and reduced time with dyskinesia in Parkinson's Disease by Wictorin, K, Widner, H

“…The partial glutamate antagonist amantadine is currently used in clinical practice, to reduce dyskinesia developing as a side-effect of levodopa treatment in…”
Get full text

A Phase 2a Trial Investigating the Safety and Tolerability of the Novel Cortical Enhancer IRL752 in Parkinson's Disease Dementia by Svenningsson, Per, Odin, Per, Dizdar, Nil, Johansson, Anders, Grigoriou, Sotirios, Tsitsi, Panagiota, Wictorin, Klas, Bergquist, Filip, Nyholm, Dag, Rinne, Juha, Hansson, Fredrik, Sonesson, Clas, Tedroff, Joakim, Andersson, Kristina, Sundgren, Mathias, Duzynski, Wojciech, Carlström, Christian

“…Background IRL752 is a novel small‐molecule compound that acts to regioselectively enhance norepinephrine, dopamine, and acetylcholine neurotransmission in the…”
Get full text

Anatomy and connectivity of intrastriatal striatal transplants by Wictorin, K

Get more information

Projection neurons in fetal striatal transplants are predominantly derived from the lateral ganglionic eminence by Olsson, M., Campbell, K., Wictorin, K., Björklund, A.

“…In the present study, we have characterized aspects of integration, growth and phenotypic differentation of embryonic grafts derived from the selective…”
Get full text

Amelioration of cholinergic neuron atrophy and spatial memory impairment in aged rats by nerve growth factor by Fischer, W, Wictorin, K, Björklund, A, Williams, L. R, Varon, S, Gage, F. H

“…In aged rodents, impairments in learning and memory have been associated with an age-dependent decline in forebrain of cholinergic function, and recent…”
Get full text

Long distance directed axonal growth from human dopaminergic mesencephalic neuroblasts implanted along the nigrostriatal pathway in 6-hydroxydopamine lesioned adult rats by Wictorin, K, Brundin, P, Sauer, H, Lindvall, O, Björklund, A

“…Dissociated ventral mesencephalon of 6 to 8-week-old human embryos were implanted by stereotaxic injection at different sites along the nigrostriatal pathway…”
Get more information

Continuous Infusion of Nerve Growth Factor Prevents Basal Forebrain Neuronal Death after Fimbria Fornix Transection by Williams, Lawrence R., Varon, Silvio, Peterson, Gary M., Wictorin, Klas, Fischer, Walter, Bjorklund, Anders, Gage, Fred H.

“…Neurons in the rat medial septum (MS) and vertical limb of the diagonal band of Broca (VDB) undergo a rapid and severe cell death after transection of their…”
Get full text

Memantine and reduced time with dyskinesia in Parkinson′s Disease by Wictorin, K., Widner, H.

“…Objectives The partial glutamate antagonist amantadine is currently used in clinical practice, to reduce dyskinesia developing as a side‐effect of levodopa…”
Get full text

Extensive migration and target innervation by striatal precursors after grafting into the neonatal striatum by Olsson, M, Bentlage, C, Wictorin, K, Campbell, K, Björklund, A

“…Embryonic striatal precursors grafted into the lesioned adult host striatum show limited integration with little migration and restricted efferent projections…”
Get full text

Eltoprazine counteracts l-DOPA-induced dyskinesias in Parkinson's disease: a dose-finding study by Svenningsson, Per, Rosenblad, Carl, Af Edholm Arvidsson, Karolina, Wictorin, Klas, Keywood, Charlotte, Shankar, Bavani, Lowe, David A, Björklund, Anders, Widner, Håkan

“…In advanced stages of Parkinson's disease, serotonergic terminals take up L-DOPA and convert it to dopamine. Abnormally released dopamine may participate in…”
Get full text

Neurotransmitter-related gene expression in intrastriatal striatal transplants—I. Phenotypical characterization of striatal and non-striatal graft regions by Campbell, K., Wictorin, K., Björklund, A.

“…In the present study, we have re-examined the heterogeneous nature of intrastriatal striatal transplants derived from embryonic day 14–15 rat striatal…”
Get full text

Connectivity of striatal grafts implanted into the ibotenic acid-lesioned striatum--II. Cortical afferents by Wictorin, K, Björklund, A

“…Grafts of fetal striatal tissue, implanted into the ibotenic acid-lesioned caudate-putamen in adult recipient rats, have previously been shown to receive…”
Get more information

Enhanced synthesis of platelet-derived growth factor following injury induced by 6-hydroxydopamine in rat brain by Funa, K, Yamada, N, Brodin, G, Pietz, K, Åhgren, A, Wictorin, K, Lindvall, O, Odin, P

“…The kinetics of platelet-derived growth factor messenger RNA synthesis in the substantia nigra and in the striatum, before and after unilateral intranigral…”
Get full text

Characterization of GABA release from intrastriatal striatal transplants: dependence on host-derived afferents by Campbell, K, Kalén, P, Wictorin, K, Lundberg, C, Mandel, R J, Björklund, A

“…Extracellular levels of GABA, derived from cell suspension transplants of embryonic day 14-15 rat striatal primordia implanted into the previously…”
Get more information

Differential Regulation of Neuropeptide mRNA Expression in Intrastriatal Striatal Transplants by Host Dopaminergic Afferents by Campbell, Kenneth, Wictorin, Klas, Bjorklund, Anders

“…The effects of dopamine-specific manipulations on neuropeptide gene expression in intrastriatal grafts of fetal striatal tissue were studied by quantitative in…”
Get full text

Connectivity of striatal grafts implanted into the ibotenic acid-lesioned striatum--I. Subcortical afferents by Wictorin, K, Isacson, O, Fischer, W, Nothias, F, Peschanski, M, Björklund, A

“…Subcortical afferents to transplants of fetal striatal tissue, implanted into the excitotoxically lesioned striatum of adult recipient rats, were studied with…”
Get more information

Neurotransmitter-related gene expression in intrastriatal striatal transplants—II. Characterization of efferent projecting graft neurons by Campbell, K., Wictorin, K., Björklund, A.

“…The phenotypic characteristics of identified graft neurons in intrastriatal striatal transplants which give rise to efferent projections innervating the host…”
Get full text

Dopaminergic transplants normalize amphetamine- and apomorphine-induced Fos expression in the 6-hydroxydopamine-lesioned striatum by Cenci, M A, Kalén, P, Mandel, R J, Wictorin, K, Björklund, A

“…Dopamine receptor-mediated Fos protein expression in the striatum has been used to monitor dopamine receptor activation at the cellular level after…”
Get more information

Connectivity of striatal grafts implanted into the ibotenic acid-lesioned striatum--III. Efferent projecting graft neurons and their relation to host afferents within the grafts by Wictorin, K, Simerly, R B, Isacson, O, Swanson, L W, Björklund, A

“…Efferent projections of intrastriatally implanted striatal neurons have been studied using a combination of anterograde and retrograde axonal tracers. Adult…”
Get more information

Development of intrastriatal striatal grafts and their afferent innervation from the host by Labandeira-Garcia, J L, Wictorin, K, Cunningham, Jr, E T, Björklund, A

“…The morphological maturation of cell suspension grafts of fetal striatal tissue (obtained from 14-15-day-old rat fetuses) was followed from two days to eight…”
Get more information