Search Results - "Wicks, Nadine L."

UVA Phototransduction Drives Early Melanin Synthesis in Human Melanocytes by Wicks, Nadine L., Chan, Jason W., Najera, Julia A., Ciriello, Jonathan M., Oancea, Elena

“…Exposure of human skin to solar ultraviolet radiation (UVR), a powerful carcinogen [1] comprising ∼95% ultraviolet A (UVA) and ∼5% ultraviolet B (UVB) at the…”
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Opsin Expression in Human Epidermal Skin by Haltaufderhyde, Kirk, Ozdeslik, Rana N., Wicks, Nadine L., Najera, Julia A., Oancea, Elena

“…Human skin is constantly exposed to solar light containing visible and ultraviolet radiation (UVR), a powerful skin carcinogen. UVR elicits cellular responses…”
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Melanosomal dynamics assessed with a live-cell fluorescent melanosomal marker by Bruder, Jan M, Pfeiffer, Zachary A, Ciriello, Jonathan M, Horrigan, Diana M, Wicks, Nadine L, Flaherty, Benjamin, Oancea, Elena

“…Melanocytes present in skin and other organs synthesize and store melanin pigment within membrane-delimited organelles called melanosomes. Exposure of human…”
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Cytoplasmic cAMP-sensing domain of hyperpolarization-activated cation (HCN) channels uses two structurally distinct mechanisms to regulate voltage gating by Wicks, Nadine L., Wong, Tammy, Sun, Jinyi, Madden, Zarina, Young, Edgar C., Aldrich, Richard W.

“…Voltage gating of hyperpolarization-activated cation (HCN) channels is potentiated by direct binding of cAMP to a cytoplasmic cAMP-sensing domain (CSD). When…”
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TRPM1: new trends for an old TRP by Oancea, Elena, Wicks, Nadine L

“…TRPM1, initially named Melastatin, is the founding member of the TRPM subfamily of Transient Receptor Potential (TRP) ion channels. Despite sustained efforts,…”
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Sensitivity of HCN channel deactivation to cAMP is amplified by an S4 mutation combined with activation mode shift by Wicks, Nadine L., Chan, Kerry S. C., Madden, Zarina, Santoro, Bina, Young, Edgar C.

“…Hyperpolarisation–activation of HCN ion channels relies on the movement of a charged S4 transmembrane helix, preferentially stabilising the open conformation…”
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Modulation of HCN Channel Deactivation Kinetics by CAMP and Depolarization Can Be Amplified by Mode Shift by Wicks, Nadine L., Chan, Kerry S.C., Young, Edgar C.

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Mechanisms of cyclic AMP-dependent modulation in pacemaker channels by Wicks, Nadine L

“…Pacemaker (HCN) channels are hyperpolarization-activated and their activity is enhanced by cyclic AMP (cAMP), but whether cAMP-gating is coupled to…”
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