Adipokine levels and their association with clinical disease severity in patients with dengue

Adipokines have not been studied in acute dengue, despite their emerging role in inducing and regulating inflammation. Therefore, we sought to identify adipokine levels in patients with varying severities of acute dengue to understand their role in disease pathogenesis. We determined the levels of l...

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Bibliographic Details
Published in:	PLoS neglected tropical diseases Vol. 17; no. 9; p. e0011613
Main Authors:	Kuruppu, Heshan, Wickramanayake, W. P Rivindu H, Jeewandara, Chandima, Peranantharajah, Deneshan, Colambage, H. S, Perera, Lahiru, Gomes, Laksiri, Wijewickrama, Ananda, Ogg, Graham S, Malavige, Gathsaurie Neelika
Format:	Journal Article
Language:	English
Published:	San Francisco Public Library of Science 07-09-2023 Public Library of Science (PLoS)
Subjects:	Adiponectin Biology and Life Sciences Care and treatment Chronic illnesses Correlation COVID-19 Cytokines Dengue fever Dengue hemorrhagic fever Development and progression Diabetes Diagnosis ELISA Enzyme-linked immunosorbent assay Ethics Evaluation Human diseases Hypertension Infections Infectious diseases Inflammation Influenza Interferon Laboratories Leptin Liver Medicine and Health Sciences Metabolic disorders Nucleotide sequence Obesity Pathogenesis Patients PCR Proteins Real time Risk factors Serotypes Severe acute respiratory syndrome coronavirus 2 Statistical analysis Therapeutic targets Ultrasonic imaging Vector-borne diseases Viral diseases β-Interferon Sri Lanka United States > US
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Summary:	Adipokines have not been studied in acute dengue, despite their emerging role in inducing and regulating inflammation. Therefore, we sought to identify adipokine levels in patients with varying severities of acute dengue to understand their role in disease pathogenesis. We determined the levels of leptin, resistin, omentin, adiponectin, as well as IFNβ, and NS1 using quantitative ELISA in patients with dengue fever (DF = 49) and dengue haemorrhagic fever (DHF = 22) at admission (febrile phase) and at the time of discharge (recovery phase). The viral loads and serotypes of all samples were quantified using quantitative real-time RT-PCR. Resistin levels (p = 0.04) and omentin (p = 0.006) levels were significantly higher in patients who developed DHF. Omentin levels in the febrile phase also correlated with the AST (Spearman’s r = 0.38, p = 0.001) and ALT levels (Spearman’s r = 0.24, p = 0.04); as well as serum leptin levels with both AST (Spearman’s r = 0.27, p = 0.02) and ALT (Spearman’s r = 0.28, p = 0.02). Serum adiponectin levels in the febrile phase did not correlate with any of the other adipokines or with liver enzymes, but inversely correlated with CRP levels (Spearman’s r = -0.31, p = 0.008). Although not significant (p = 0.14) serum IFNβ levels were lower in the febrile phase in those who progressed to develop DHF (median 0, IQR 0 to 39.4 pg/ml), compared to those who had DF (median 37.1, IQR 0 to 65.6 pg.ml). The data suggest that adipokines are likely to play a role in the pathogenesis of dengue, which should be further explored for the potential to be used as prognostic markers and as therapeutic targets.
Bibliography:	new_version ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 The authors have no competing interests.
ISSN:	1935-2735 1935-2727 1935-2735
DOI:	10.1371/journal.pntd.0011613