Search Results - "Wicker, L. S"

Analysis of 17 autoimmune disease-associated variants in type 1 diabetes identifies 6q23/TNFAIP3 as a susceptibility locus by Fung, E Y M G, Smyth, D J, Howson, J M M, Cooper, J D, Walker, N M, Stevens, H, Wicker, L S, Todd, J A

“…As a result of genome-wide association studies in larger sample sets, there has been an increase in identifying genes that influence susceptibility to…”
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Multi‐parametric flow cytometric and genetic investigation of the peripheral B cell compartment in human type 1 diabetes by Thompson, W. S., Pekalski, M. L., Simons, H. Z., Smyth, D. J., Castro‐Dopico, X., Guo, H., Guy, C., Dunger, D. B., Arif, S., Peakman, M., Wallace, C., Wicker, L. S., Todd, J. A, Ferreira, R. C.

“…Summary The appearance of circulating islet‐specific autoantibodies before disease diagnosis is a hallmark of human type 1 diabetes (T1D), and suggests a role…”
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Induction of autoimmune cholangitis in non-obese diabetic (NOD).1101 mice following a chemical xenobiotic immunization by Wakabayashi, K, Yoshida, K, Leung, P.S.C, Moritoki, Y, Yang, G.-X, Tsuneyama, K, Lian, Z.-X, Hibi, T, Ansari, A.A, Wicker, L.S, Ridgway, W.M, Coppel, R.L, Mackay, I.R, Gershwin, M.E

“…Our laboratory has suggested that loss of tolerance to pyruvate dehydrogenase (PDC-E2) leads to an anti-mitochondrial antibody response and autoimmune…”
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type 1 diabetes subgroup with a female bias is characterised by failure in tolerance to thyroid peroxidase at an early age and a strong association with the cytotoxic T-lymphocyte-associated antigen-4 gene by Howson, J. M. M, Dunger, D. B, Nutland, S, Stevens, H, Wicker, L. S, Todd, J. A

“…Aims/hypothesis HLA haplotypes DRB1*03_DQB1*02 and DRB1*04_DQB1*0302, and allelic variation of the T cell regulatory gene cytotoxic T-lymphocyte-associated…”
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NOD Idd5 locus controls insulitis and diabetes and overlaps the orthologous CTLA4/IDDM12 and NRAMP1 loci in humans by HILL, Natasha J, LYONS, Paul A, ARMITAGE, Nicola, TODD, John A, WICKER, Linda S, PETERSON, Laurence B

“…NOD Idd5 locus controls insulitis and diabetes and overlaps the orthologous CTLA4/IDDM12 and NRAMP1 loci in humans. N J Hill , P A Lyons , N Armitage , J A…”
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Beta 2-microglobulin-deficient NOD mice do not develop insulitis or diabetes by Wicker, L S, Leiter, E H, Todd, J A, Renjilian, R J, Peterson, E, Fischer, P A, Podolin, P L, Zijlstra, M, Jaenisch, R, Peterson, L B

“…Beta 2-microglobulin-deficient NOD mice do not develop insulitis or diabetes. L S Wicker , E H Leiter , J A Todd , R J Renjilian , E Peterson , P A Fischer , P…”
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Localization of two insulin-dependent diabetes (Idd) genes to the Idd10 region on mouse Chromosome 3 by Podolin, P L, Denny, P, Armitage, N, Lord, C J, Hill, N J, Levy, E R, Peterson, L B, Todd, J A, Wicker, L S, Lyons, P A

“…Multiple genes control the development of autoimmune diabetes both in humans and in the nonobese diabetic (NOD) strain of mouse. Previously, three…”
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CD226 Gly307Ser association with multiple autoimmune diseases by Hafler, J P, Maier, L M, Cooper, J D, Plagnol, V, Hinks, A, Simmonds, M J, Stevens, H E, Walker, N M, Healy, B, Howson, J M M, Maisuria, M, Duley, S, Coleman, G, Gough, S C L, Worthington, J, Kuchroo, V K, Wicker, L S, Todd, J A

“…Genome-wide association studies provide insight into multigenic diseases through the identification of susceptibility genes and etiological pathways. In…”
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Both the Lyt-2+ and L3T4+ T cell subsets are required for the transfer of diabetes in nonobese diabetic mice by Miller, B.J, Appel, M.C, O'Neil, J.J, Wicker, L.S

“…The nonobese diabetic mouse is a model of spontaneous type I diabetes mellitus. It is possible to induce diabetes in young, irradiated nonobese diabetic mice…”
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Analysis of the mouse CD30 gene: a candidate for the NOD mouse type 1 diabetes locus Idd9.2 by SIEGMUND, T, ARMITAGE, N, WICKER, L. S, PETERSON, L. B, TODD, J. A, LYONS, P. A

“…Analysis of the mouse CD30 gene: a candidate for the NOD mouse type 1 diabetes locus Idd9.2. T Siegmund , N Armitage , L S Wicker , L B Peterson , J A Todd and…”
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Exploration of requirements for peptide binding to HLA DRB10101 and DRB10401 by Hill, CM, Liu, A, Marshall, KW, Mayer, J, Jorgensen, B, Yuan, B, Cubbon, RM, Nichols, EA, Wicker, LS, Rothbard, JB

“…The individual amino acid contacts responsible for peptide binding to DRB1*0101 and/or DRB1*0401 were defined using a quantitative binding assay. The…”
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I-E+ nonobese diabetic mice develop insulitis and diabetes by PODOLIN, P. L, PRESSEY, A, DELARATO, N. H, FISCHER, P. A, PETERSON, L. B, WICKER, L. S

“…The development of type I diabetes in the nonobese diabetic (NOD) mouse is under the control of multiple genes, one or more of which is linked to the major…”
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Autoimmune syndromes in major histocompatibility complex (MHC) congenic strains of nonobese diabetic (NOD) mice. The NOD MHC is dominant for insulitis and cyclophosphamide-induced diabetes by WICKER, L. S, APPEL, M. C, DOTTA, F, PRESSEY, A, MILLER, B. J, DELARATO, M. H, FISCHER, P. A, BOLTZ, R. C, PETERSON, L. B

“…The development of autoimmune diabetes in the nonobese diabetic (NOD) mouse is controlled by multiple genes. At least one diabetogenic gene is linked to the…”
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Mapping of the IDDM locus Idd3 to a 0.35-cM interval containing the interleukin-2 gene by Denny, P., Lord, C. J., Hill, N. J., Goy, J. V., Levy, E. R., Podolin, P. L., Peterson, L. B., Wicker, L. S., Todd, J. A., Lyons, P. A.

“…Mapping of the IDDM locus Idd3 to a 0.35-cM interval containing the interleukin-2 gene. P Denny , C J Lord , N J Hill , J V Goy , E R Levy , P L Podolin , L B…”
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Transfer of autoimmune diabetes mellitus with splenocytes from nonobese diabetic (NOD) mice by WICKER, L. S, MILLER, B. J, MULLEN, Y

“…The nonobese diabetic (NOD) mouse, a model of human type I diabetes, develops insulitis beginning at 4-6 wk of age. By 30 wk of age, 72% of females and 39% of…”
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Transfer of autoimmune diabetes mellitus with splenocytes from nonobese diabetic (NOD) mice by Wicker, L. S., Miller, B. J., Mullen, Y.

“…Transfer of autoimmune diabetes mellitus with splenocytes from nonobese diabetic (NOD) mice. L S Wicker , B J Miller and Y Mullen Abstract The nonobese…”
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Genetic control of diabetes and insulitis in the nonobese diabetic (NOD) mouse by WICKER, L. S, MILLER, B. J, COKER, L. Z, MCNALLY, S. E, SCOTT, S, MULLEN, Y, APPEL, M. C

“…Genetic analysis of the development of diabetes and insulitis has been performed in the nonobese diabetic (NOD) mouse strain, a model of insulin-dependent…”
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Type 1 diabetes in mice is linked to the interleukin-1 receptor and LSh/Ity/Bcg genes on chromosome 1 by CORNALL, R. J, PRINS, J.-B, TODD, J. A, PRESSEY, A, DELARATO, N. H, WICKER, L. S, PETERSON, L. B

“…Human type 1 (insulin-dependent) diabetes is a common auto-immune disease of the insulin-producing beta cells of the pancreas which is caused by both genetic…”
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An autoimmune disease-associated CTLA-4 splice variant lacking the B7 binding domain signals negatively in T cells by Vijayakrishnan, Lalitha, Slavik, Jacqueline M, Illés, Zsolt, Greenwald, Rebecca J, Rainbow, Dan, Greve, Bernhard, Peterson, Laurence B, Hafler, David A, Freeman, Gordon J, Sharpe, Arlene H, Wicker, Linda S, Kuchroo, Vijay K

“…Cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) plays a critical role in downregulating T cell responses. A number of autoimmune diseases have shown…”
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Genetic Protection from the Inflammatory Disease Type 1 Diabetes in Humans and Animal Models by Todd, John A, Wicker, Linda S

“…Populations of humans and mice contain alleles at many loci that protect from immune-mediated diseases. Identification of these alleles, some which are likely…”
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