Search Results - "Wickens, Zachary K."

Photoinduced Hydrocarboxylation via Thiol-Catalyzed Delivery of Formate Across Activated Alkenes by Alektiar, Sara N, Wickens, Zachary K

“…Herein we disclose a new photochemical process to prepare carboxylic acids from formate salts and alkenes. This redox-neutral hydrocarboxylation proceeds in…”
Get full text

Electrochemical Synthesis of Allylic Amines from Terminal Alkenes and Secondary Amines by Wang, Diana J, Targos, Karina, Wickens, Zachary K

“…Allylic amines are valuable synthetic targets en route to diverse biologically active amine products. Current allylic C–H amination strategies remain limited…”
Get full text

Potent Reductants via Electron-Primed Photoredox Catalysis: Unlocking Aryl Chlorides for Radical Coupling by Cowper, Nicholas G. W, Chernowsky, Colleen P, Williams, Oliver P, Wickens, Zachary K

“…We describe a new catalytic strategy to transcend the energetic limitations of visible light by electrochemically priming a photocatalyst prior to excitation…”
Get full text

Aziridine synthesis by coupling amines and alkenes via an electrogenerated dication by Holst, Dylan E., Wang, Diana J., Kim, Min Ji, Guzei, Ilia A., Wickens, Zachary K.

“…Aziridines—three-membered nitrogen-containing cyclic molecules—are important synthetic targets. Their substantial ring strain and resultant proclivity towards…”
Get full text

Highly Enantioselective, Hydrogen-Bond-Donor Catalyzed Additions to Oxetanes by Strassfeld, Daniel A, Wickens, Zachary K, Picazo, Elias, Jacobsen, Eric N

“…A precisely designed chiral squaramide derivative is shown to promote the highly enantioselective addition of trimethylsilyl bromide (TMSBr) to a broad variety…”
Get full text

Primary Alcohols from Terminal Olefins: Formal Anti-Markovnikov Hydration via Triple Relay Catalysis by Dong, Guangbin, Teo, Peili, Wickens, Zachary K., Grubbs, Robert H.

“…Alcohol synthesis is critical to the chemical and pharmaceutical industries. The addition of water across olefins to form primary alcohols (anti-Markovnikov…”
Get full text

Catalyst-Controlled Wacker-Type Oxidation: Facile Access to Functionalized Aldehydes by Wickens, Zachary K, Skakuj, Kacper, Morandi, Bill, Grubbs, Robert H

“…The aldehyde-selective oxidation of alkenes bearing diverse oxygen groups in the allylic and homoallylic position was accomplished with a nitrite-modified…”
Get full text

Practical and General Palladium-Catalyzed Synthesis of Ketones from Internal Olefins by Morandi, Bill, Wickens, Zachary K., Grubbs, Robert H.

“…Make it simple! A convenient and general palladium‐catalyzed oxidation of internal olefins to ketones is reported. The transformation occurs at room…”
Get full text

Regioselective Wacker Oxidation of Internal Alkenes: Rapid Access to Functionalized Ketones Facilitated by Cross-Metathesis by Morandi, Bill, Wickens, Zachary K., Grubbs, Robert H.

“…Wacka wacka: The title reaction makes use of a wide range of directing groups (DG) to enable the highly regioselective oxidation of alkenes, and occurs…”
Get full text

Tandem Z-Selective Cross-Metathesis/Dihydroxylation: Synthesis of anti-1,2-Diols by Dornan, Peter K., Wickens, Zachary K., Grubbs, Robert H.

“…A stereoselective synthesis of anti‐1,2‐diols has been developed using a multitasking Ru catalyst in an assisted tandem catalysis protocol. A cyclometalated Ru…”
Get full text

Unveiling Potent Photooxidation Behavior of Catalytic Photoreductants by Targos, Karina, Williams, Oliver P, Wickens, Zachary K

“…We describe a photocatalytic system that reveals latent photooxidant behavior from one of the most reducing conventional photoredox catalysts,…”
Get full text

Electrochemical Activation of Diverse Conventional Photoredox Catalysts Induces Potent Photoreductant Activity by Chernowsky, Colleen P., Chmiel, Alyah F., Wickens, Zachary K.

“…Herein, we disclose that electrochemical stimulation induces new photocatalytic activity from a range of structurally diverse conventional photocatalysts…”
Get full text

Non-innocent Radical Ion Intermediates in Photoredox Catalysis: Parallel Reduction Modes Enable Coupling of Diverse Aryl Chlorides by Chmiel, Alyah F, Williams, Oliver P, Chernowsky, Colleen P, Yeung, Charles S, Wickens, Zachary K

“…We describe a photocatalytic system that elicits potent photoreductant activity from conventional photocatalysts by leveraging radical anion intermediates…”
Get full text

Radical Hydrocarboxylation of Unactivated Alkenes via Photocatalytic Formate Activation by Alektiar, Sara N., Han, Jimin, Dang, Y, Rubel, Camille Z., Wickens, Zachary K.

“…Herein we disclose a strategy to promote the hydrocarboxylation of unactivated alkenes using photochemical activation of formate salts. We illustrate that an…”
Get full text

Translating Planar Heterocycles into Three‐Dimensional Analogs by Photoinduced Hydrocarboxylation by Mikhael, Myriam, Alektiar, Sara N., Yeung, Charles S., Wickens, Zachary K.

“…The rapid preparation of complex three‐dimensional (3D) heterocyclic scaffolds is a key challenge in modern medicinal chemistry. Despite the increased…”
Get full text

Aldehyde-Selective Wacker-Type Oxidation of Unbiased Alkenes Enabled by a Nitrite Co-Catalyst by Wickens, Zachary K., Morandi, Bill, Grubbs, Robert H.

“…Breaking the rules: Reversal of the high Markovnikov selectivity of Wacker‐type oxidations was accomplished using a nitrite co‐catalyst. Unbiased aliphatic…”
Get full text

A Case Study in Catalyst Generality: Simultaneous, Highly-Enantioselective Brønsted- and Lewis-Acid Mechanisms in Hydrogen-Bond-Donor Catalyzed Oxetane Openings by Strassfeld, Daniel A, Algera, Russell F, Wickens, Zachary K, Jacobsen, Eric N

“…Generality in asymmetric catalysis can be manifested in dramatic and valuable ways, such as high enantioselectivity across a wide assortment of substrates in a…”
Get full text

Regiospecific Alkene Aminofunctionalization via an Electrogenerated Dielectrophile by Holst, Dylan E., Dorval, Céline, Winter, Casey K., Guzei, Ilia A., Wickens, Zachary K.

“…Modular strategies to rapidly increase molecular complexity have proven immensely synthetically valuable. In principle, transformation of an alkene into a…”
Get full text

Alkene Thianthrenation Unlocks Diverse Cation Synthons: Recent Progress and New Opportunities by Kim, Min Ji, Targos, Karina, Holst, Dylan E., Wang, Diana J., Wickens, Zachary K.

“…Oxidative alkene functionalization reactions are a fundamental class of complexity‐building organic transformations. However, the majority of established…”
Get full text

Practical and General Alcohol Deoxygenation Protocol by Williams, Oliver P., Chmiel, Alyah F., Mikhael, Myriam, Bates, Desiree M., Yeung, Charles S., Wickens, Zachary K.

“…Herein, we describe a practical protocol for the removal of alcohol functional groups through reductive cleavage of their benzoate ester analogs. This…”
Get full text