Search Results - "Wickens, R."

Research Review: Dopamine transfer deficit: a neurobiological theory of altered reinforcement mechanisms in ADHD by Tripp, Gail, Wickens, Jeff R.

“…This review considers the hypothesis that changes in dopamine signalling might account for altered sensitivity to positive reinforcement in children with ADHD…”
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Striatal Cholinergic Signaling in Time and Space by Nosaka, Dvyne, Wickens, Jeffery R

“…The cholinergic interneurons of the striatum account for a small fraction of all striatal cell types but due to their extensive axonal arborization give the…”
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Role of Striatal Cholinergic Interneurons in Set-Shifting in the Rat by Aoki, Sho, Liu, Andrew W, Zucca, Aya, Zucca, Stefano, Wickens, Jeffery R

“…The ability to change strategies in different contexts is a form of behavioral flexibility that is crucial for adaptive behavior. The striatum has been shown…”
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An open cortico-basal ganglia loop allows limbic control over motor output via the nigrothalamic pathway by Aoki, Sho, Smith, Jared B, Li, Hao, Yan, Xunyi, Igarashi, Masakazu, Coulon, Patrice, Wickens, Jeffery R, Ruigrok, Tom Jh, Jin, Xin

“…Cortico-basal ganglia-thalamocortical loops are largely conceived as parallel circuits that process limbic, associative, and sensorimotor information…”
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Coincidence of cholinergic pauses, dopaminergic activation and depolarisation of spiny projection neurons drives synaptic plasticity in the striatum by Reynolds, John N. J., Avvisati, Riccardo, Dodson, Paul D., Fisher, Simon D., Oswald, Manfred J., Wickens, Jeffery R., Zhang, Yan-Feng

“…Dopamine-dependent long-term plasticity is believed to be a cellular mechanism underlying reinforcement learning. In response to reward and reward-predicting…”
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Conditioned approach behavior of SHR and SD rats during Pavlovian conditioning by Silic, Bozena, Aggarwal, Mayank, Liyanagama, Kavinda, Tripp, Gail, Wickens, Jeffery R.

“…Individual differences in reward-related learning are relevant to many behavioral disorders. Sensory cues that predict reward can become incentive stimuli that…”
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Synaptic plasticity in the basal ganglia by Wickens, Jeffery R.

“…Activity-dependent synaptic plasticity occurs in several parts of the basal ganglia. Increasing evidence supports the hypothesis that activity-dependent…”
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Acetylcholine waves and dopamine release in the striatum by Matityahu, Lior, Gilin, Naomi, Sarpong, Gideon A., Atamna, Yara, Tiroshi, Lior, Tritsch, Nicolas X., Wickens, Jeffery R., Goldberg, Joshua A.

“…Striatal dopamine encodes reward, with recent work showing that dopamine release occurs in spatiotemporal waves. However, the mechanism of dopamine waves is…”
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Cholinergic interneurons in the rat striatum modulate substitution of habits by Aoki, Sho, Liu, Andrew W., Akamine, Yumiko, Zucca, Aya, Zucca, Stefano, Wickens, Jeffery R.

“…Behavioural flexibility is crucial for adaptive behaviour, and recent evidence suggests that cholinergic interneurons of the striatum play a distinct role…”
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Optimal balance of the striatal medium spiny neuron network by Ponzi, Adam, Wickens, Jeffery R

“…Slowly varying activity in the striatum, the main Basal Ganglia input structure, is important for the learning and execution of movement sequences. Striatal…”
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Abnormal striatal BOLD responses to reward anticipation and reward delivery in ADHD by Furukawa, Emi, Bado, Patricia, Tripp, Gail, Mattos, Paulo, Wickens, Jeff R, Bramati, Ivanei E, Alsop, Brent, Ferreira, Fernanda Meireles, Lima, Debora, Tovar-Moll, Fernanda, Sergeant, Joseph A, Moll, Jorge

“…Altered reward processing has been proposed to contribute to the symptoms of attention deficit hyperactivity disorder (ADHD). The neurobiological mechanism…”
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The Effect of Serotonin Receptor 5-HT1B on Lateral Inhibition between Spiny Projection Neurons in the Mouse Striatum by Pommer, Stefan, Akamine, Yumiko, Schiffmann, Serge N., de Kerchove d'Exaerde, Alban, Wickens, Jeffery R.

“…The principal neurons of the striatum, the spiny projection neurons (SPNs), make inhibitory synaptic connections with each other via collaterals of their main…”
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Three-Dimensional Spatial Analyses of Cholinergic Neuronal Distributions Across The Mouse Septum, Nucleus Basalis, Globus Pallidus, Nucleus Accumbens, and Caudate-Putamen by Carrasco, Andres, Oorschot, Dorothy E., Barzaghi, Paolo, Wickens, Jeffery R.

“…Neuronal networks are regulated by three-dimensional spatial and structural properties. Despite robust evidence of functional implications in the modulation of…”
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Methylphenidate modifies reward cue responses in adults with ADHD: An fMRI study by Furukawa, Emi, da Costa, Raquel Quimas Molina, Bado, Patricia, Hoefle, Sebastian, Vigne, Paula, Monteiro, Myriam, Wickens, Jeff R., Moll, Jorge, Tripp, Gail, Mattos, Paulo

“…Attention deficit hyperactivity disorder (ADHD) has been associated with neural hyposensitivity to reward-predicting cues. Methylphenidate is widely used in…”
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Reward modality modulates striatal responses to reward anticipation in ADHD: Effects of affiliative and food stimuli by Furukawa, Emi, Bado, Patricia, da Costa, Raquel Quimas Molina, Melo, Bruno, Erthal, Pilar, de Oliveira, Iara Peixoto, Wickens, Jeff R, Moll, Jorge, Tripp, Gail, Mattos, Paulo

“…•Hyporesponsiveness to reward-predicting cues in ADHD extends beyond monetary rewards.•Adults with ADHD show decreased striatal activation to affiliative…”
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Dopamine Cells Respond to Predicted Events during Classical Conditioning: Evidence for Eligibility Traces in the Reward-Learning Network by Pan, Wei-Xing, Schmidt, Robert, Wickens, Jeffery R, Hyland, Brian I

“…Behavioral conditioning of cue-reward pairing results in a shift of midbrain dopamine (DA) cell activity from responding to the reward to responding to the…”
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Role of homeostatic feedback mechanisms in modulating methylphenidate actions on phasic dopamine signaling in the striatum of awake behaving rats by Fuller, Justine A, Burrell, Mark H, Yee, Andrew G, Liyanagama, Kavinda, Lipski, Janusz, Wickens, Jeffery R, Hyland, Brian I

“…Methylphenidate is an established treatment for attention-deficit hyperactivity disorder that also has abuse potential. Both properties may relate to blocking…”
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A cellular mechanism of reward-related learning by Wickens, Jeffery R, Reynolds, John N. J, Hyland, Brian I

“…Positive reinforcement helps to control the acquisition of learned behaviours. Here we report a cellular mechanism in the brain that may underlie the…”
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Active propagation of dendritic electrical signals in C. elegans by Shindou, Tomomi, Ochi-Shindou, Mayumi, Murayama, Takashi, Saita, Ei-ichiro, Momohara, Yuto, Wickens, Jeffery R., Maruyama, Ichiro N.

“…Active propagation of electrical signals in C . elegans neurons requires ion channels capable of regenerating membrane potentials. Here we report regenerative…”
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Simvastatin activates single skeletal RyR1 channels but exerts more complex regulation of the cardiac RyR2 isoform by Venturi, Elisa, Lindsay, Chris, Lotteau, Sabine, Yang, Zhaokang, Steer, Emma, Witschas, Katja, Wilson, Abigail D, Wickens, James R, Russell, Angela J, Steele, Derek, Calaghan, Sarah, Sitsapesan, Rebecca

“…Background and Purpose Statins are amongst the most widely prescribed drugs for those at risk of cardiovascular disease, lowering cholesterol levels by…”
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