Search Results - "Wichman, A"

Experimental evolution of viruses: Microviridae as a model system by Wichman, Holly A., Brown, Celeste J.

“…φX174 was developed as a model system for experimental studies of evolution because of its small genome size and ease of cultivation. It has been used…”
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Tracing the history of LINE and SINE extinction in sigmodontine rodents by Yang, Lei, Scott, LuAnn, Wichman, Holly A

“…L1 retrotransposons have co-evolved with their mammalian hosts for the entire history of mammals and currently compose ~ 20% of a mammalian genome. B1…”
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Epistasis between beneficial mutations and the phenotype-to-fitness Map for a ssDNA virus by Rokyta, Darin R, Joyce, Paul, Caudle, S Brian, Miller, Craig, Beisel, Craig J, Wichman, Holly A

“…Epistatic interactions between genes and individual mutations are major determinants of the evolutionary properties of genetic systems and have therefore been…”
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Modeling the Directed Evolution of Broad Host Range Phages by Bull, James J, Wichman, Holly A, Krone, Stephen M

“…The host ranges of individual phages tend to be narrow, yet many applications of phages would benefit from expanded host ranges. Empirical methods have been…”
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Ecological Approach to Understanding Superinfection Inhibition in Bacteriophage by Biggs, Karin R H, Bailes, Clayton L, Scott, LuAnn, Wichman, Holly A, Schwartz, Elissa J

“…In microbial communities, viruses compete with each other for host cells to infect. As a consequence of competition for hosts, viruses evolve inhibitory…”
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Controlling Recombination to Evolve Bacteriophages by Bull, James J, Wichman, Holly A, Krone, Stephen M, Molineux, Ian J

“…Recombination among different phages sometimes facilitates their ability to grow on new hosts. Protocols to direct the evolution of phage host range, as might…”
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Welfare indicators in laying hens in relation to nest exclusion by Alm, M., Tauson, R., Holm, L., Wichman, A., Kalliokoski, O., Wall, H.

“…Consumer concerns about the welfare of laying hens are increasing, leading to increased interest in identifying reliable ways to assess welfare. The present…”
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Horizontal Gene Transfer and the Evolution of Microvirid Coliphage Genomes by ROKYTA, D. R, BURCH, C. L, CAUDLE, S. B, WICHMAN, H. A

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Positive selection and multiple losses of the LINE-1-derived L1TD1 gene in mammals suggest a dual role in genome defense and pluripotency by McLaughlin, Jr, Richard N, Young, Janet M, Yang, Lei, Neme, Rafik, Wichman, Holly A, Malik, Harmit S

“…Mammalian genomes comprise many active and fossilized retroelements. The obligate requirement for retroelement integration affords host genomes an opportunity…”
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Welfare and performance in layers following temporary exclusion from the litter area on introduction to the layer facility by Alm, M., Wall, H., Holm, L., Wichman, A., Palme, R., Tauson, R.

“…When introduced to the laying facility, pullets are sometimes temporarily excluded from the litter area in order to help them locate food and water, and to…”
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Changing folding and binding stability in a viral coat protein: a comparison between substitutions accessible through mutation and those fixed by natural selection by Miller, Craig R, Lee, Kuo Hao, Wichman, Holly A, Ytreberg, F Marty

“…Previous studies have shown that most random amino acid substitutions destabilize protein folding (i.e. increase the folding free energy). No analogous studies…”
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Different Trajectories of Parallel Evolution During Viral Adaptation by Wichman, H. A., Badgett, M. R., Scott, L. A., Boulianne, C. M., Bull, J. J.

“…The molecular basis of adaptation is a major focus of evolutionary biology, yet the dynamic process of adaptation has been explored only piecemeal…”
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New Perspectives on Ebola Virus Evolution by Brown, Celeste J, Quates, Caleb J, Mirabzadeh, Christopher A, Miller, Craig R, Wichman, Holly A, Miura, Tanya A, Ytreberg, F Marty

“…Since the recent devastating outbreak of Ebola virus disease in western Africa, there has been significant effort to understand the evolution of the deadly…”
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Retrofitting the Genome: L1 Extinction Follows Endogenous Retroviral Expansion in a Group of Muroid Rodents by ERICKSON, Issac K, CANTRELL, Michael A, SCOTT, Luann, WICHMAN, Holly A

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Selection affects genes involved in replication during long-term evolution in experimental populations of the bacteriophage φX174 by Brown, Celeste J, Millstein, Jack, Williams, Christopher J, Wichman, Holly A

“…Observing organisms that evolve in response to strong selection over very short time scales allows the determination of the molecular mechanisms underlying…”
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Evolutionary Feedback Mediated through Population Density, Illustrated with Viruses in Chemostats by Bull, J. J., Millstein, J., Orcutt, J., Wichman, H. A.

“…A cornerstone of evolutionary ecology is that population density affects adaptation:randKselection is the obvious example. The reverse is also appreciated:…”
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Genic Incompatibilities in Two Hybrid Bacteriophages by Rokyta, Darin R., Wichman, Holly A.

“…Horizontal gene transfer and recombination play a major role in microbial evolution and have been detected in diverse groups, including many of medical…”
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Loss of LINE-1 Activity in the Megabats by Cantrell, Michael A, Scott, LuAnn, Brown, Celeste J, Martinez, Armando R, Wichman, Holly A

“…LINE-1 (L1) retrotransposons are the most abundant type of mammalian retroelement. They have profound effects on genome plasticity and have been proposed to…”
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First-step mutations for adaptation at elevated temperature increase capsid stability in a virus by Lee, Kuo Hao, Miller, Craig R, Nagel, Anna C, Wichman, Holly A, Joyce, Paul, Ytreberg, F Marty

“…The relationship between mutation, protein stability and protein function plays a central role in molecular evolution. Mutations tend to be destabilizing,…”
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Initiating a watch list for Ebola virus antibody escape mutations by Miller, Craig R, Johnson, Erin L, Burke, Aran Z, Martin, Kyle P, Miura, Tanya A, Wichman, Holly A, Brown, Celeste J, Ytreberg, F Marty

“…The 2014 Ebola virus (EBOV) outbreak in West Africa is the largest in recorded history and resulted in over 11,000 deaths. It is essential that strategies for…”
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