Search Results - "Wichems, Christine"

Response to a Monovalent 2009 Influenza A (H1N1) Vaccine by Greenberg, Michael E, Lai, Michael H, Hartel, Gunter F, Wichems, Christine H, Gittleson, Charmaine, Bennet, Jillian, Dawson, Gail, Hu, Wilson, Leggio, Connie, Washington, Diane, Basser, Russell L

“…There is an urgent need for a vaccine to prevent pandemic 2009 influenza A (H1N1) infection. In this report, 95% of adult subjects had a significant immune…”
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A Single Dose of Unadjuvanted Novel 2009 H1N1 Vaccine Is Immunogenic and Well Tolerated in Young and Elderly Adults by Talaat, Kawsar R., Greenberg, Michael E., Lai, Michael H., Hartel, Gunter F., Wichems, Christine H., Rockman, Steven, Jeanfreau, Robert J., Rita Ghosh, M., Kabongo, Martin L., Gittleson, Charmaine, Karron, Ruth A.

“…Background. When the novel H1N1 influenza A strain appeared in April of 2009, development of novel H1N1 vaccines became a public health priority. Methods. We…”
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Altered serotonin synthesis, turnover and dynamic regulation in multiple brain regions of mice lacking the serotonin transporter by Kim, Dong-Kyu, Tolliver, Teresa J., Huang, Su-Jan, Martin, Bradley J., Andrews, Anne M., Wichems, Christine, Holmes, Andrew, Lesch, Klaus-Peter, Murphy, Dennis L.

“…To evaluate the consequences of inactivation of the serotonin transporter (SERT) gene on 5-HT homeostasis and function, 5-HT synthesis and turnover rates were…”
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Brain region‐specific alterations of 5‐HT2A and 5‐HT2C receptors in serotonin transporter knockout mice by Li, Qian, Wichems, Christine H., Ma, Li, Van de Kar, Louis D., Garcia, Francisca, Murphy, Dennis L.

“…The aim of the present studies was to determine the effects of reduced or absent serotonin (5‐HT) transporters (5‐HTTs) on 5‐HT2A and 5‐HT2C receptors. The…”
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Molecular Mechanisms of Cocaine Reward: Combined Dopamine and Serotonin Transporter Knockouts Eliminate Cocaine Place Preference by Sora, Ichiro, Hall, F. Scott, Andrews, Anne M., Itokawa, Masanari, Li, Xiao-Fei, Wei, Hong-Bing, Wichems, Christine, Lesch, Klaus-Peter, Murphy, Dennis L., Uhl, George R.

“…Cocaine blocks uptake by neuronal plasma membrane transporters for dopamine (DAT), serotonin (SERT), and norepinephrine (NET). Cocaine reward/reinforcement has…”
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Cocaine Reward Models: Conditioned Place Preference can be Established in Dopamine- and in Serotonin-Transporter Knockout Mice by Sora, Ichiro, Wichems, Christine, Takahashi, Nobuyuki, Li, Xiao-Fei, Zeng, Zhizhen, Revay, Randal, Lesch, Klaus-Peter, Murphy, Dennis L., Uhl, George R.

“…Cocaine and methylphenidate block uptake by neuronal plasma membrane transporters for dopamine, serotonin, and norepinephrine. Cocaine also blocks voltagegated…”
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Cognitive response to memantine in moderate to severe alzheimer disease patients already receiving donepezil : An exploratory reanalysis by SCHMITT, Frederick A, VAN DYCK, Christopher H, WICHEMS, Christine H, OLIN, Jason T

“…To investigate the cognitive effects of the N-methyl-D-aspartate receptor antagonist, memantine, with a post-hoc exploratory reanalysis of a 24-week…”
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A systematic review of assessment and treatment of moderate to severe Alzheimer's disease by Schmitt, Frederick A, Wichems, Christine H

“…The systematic, large-scale study of therapies for moderate to severe Alzheimer's disease (AD) is a relatively recent advancement in the field. This review…”
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Altered brain serotonin homeostasis and locomotor insensitivity to 3, 4-methylenedioxymethamphetamine ("Ecstasy") in serotonin transporter-deficient mice by Bengel, D, Murphy, D L, Andrews, A M, Wichems, C H, Feltner, D, Heils, A, Mössner, R, Westphal, H, Lesch, K P

“…The sodium-dependent, high affinity serotonin [5-hydroxytryptamine (5-HT)] transporter (5-HTT) provides the primary mechanism for inactivation of 5-HT after…”
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Molecular manipulations as tools for enhancing our understanding of 5-HT neurotransmission by Murphy, Dennis L., Wichems, Christine, Li, Qian, Heils, Armin

“…A developing trend in exploring the sites at which drugs act is to use molecular rather than chemical agents to alter receptors, intracellular signalling…”
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Release of serotonin induced by 3,4-methylenedioxymethamphetamine (MDMA) and other substituted amphetamines in cultured fetal raphe neurons: further evidence for calcium-independent mechanisms of release by Wichems, Christine H., Hollingsworth, Charlotte K., Bennett, Barbara A.

“…The substituted amphetamines 3,4-methylenedioxyamphetamine (MDMA), 3,4-methylenedioxyamphetamine (MDA), p-chloroamphetamine (PCA) and fenfluramine (FEN) all…”
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Reduction in the Density and Expression, But Not G-Protein Coupling, of Serotonin Receptors (5-HT1A) in 5-HT Transporter Knock-Out Mice: Gender and Brain Region Differences by Li, Qian, Wichems, Christine, Heils, Armin, Lesch, Klaus-Peter, Murphy, Dennis L

“…The aim of the present study was to investigate the mechanisms underlying the desensitization of 5-HT(1A) receptors in the dorsal raphe and hypothalamus of…”
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Genetic perspectives on the serotonin transporter by Murphy, Dennis L., Li, Qian, Engel, Sharon, Wichems, Christine, Andrews, Anne, Lesch, Klaus-Peter, Uhl, George

“…The serotonin transporter (5-HTT) is most well known as the site of action of the serotonin reuptake inhibitors, which were initially developed as…”
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Reduction of 5-hydroxytryptamine (5-HT)(1A)-mediated temperature and neuroendocrine responses and 5-HT(1A) binding sites in 5-HT transporter knockout mice by Li, Q, Wichems, C, Heils, A, Van De Kar, L D, Lesch, K P, Murphy, D L

“…The aim of the present study was to determine whether alterations in 5-hydroxytryptamine (5-HT)(1A) receptors would be found in knockout mice lacking the…”
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Brain serotonin neurotransmission: an overview and update with an emphasis on serotonin subsystem heterogeneity, multiple receptors, interactions with other neurotransmitter systems, and consequent implications for understanding the actions of serotonergic drugs by Murphy, D L, Andrews, A M, Wichems, C H, Li, Q, Tohda, M, Greenberg, B

“…Knowledge about serotonergic neurotransmission has been expanding rapidly. Recent research has delineated 15 molecularly different serotonin receptors and…”
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Brain region‐specific alterations of 5‐HT 2A and 5‐HT 2C receptors in serotonin transporter knockout mice by Li, Qian, Wichems, Christine H., Ma, Li, Van de Kar, Louis D., Garcia, Francisca, Murphy, Dennis L.

“…Abstract The aim of the present studies was to determine the effects of reduced or absent serotonin (5‐HT) transporters (5‐HTTs) on 5‐HT 2A and 5‐HT 2C…”
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Functional Characterization of the Murine Serotonin Transporter Gene Promoter in Serotonergic Raphe Neurons by Heils, Armin, Wichems, Christine, Mössner, Rainald, Petri, Susanne, Glatz, Katharina, Bengel, Dietmar, Murphy, Dennis L., Lesch, Klaus‐Peter

“…: We have isolated and characterized the 5′‐flanking regulatory region of the murine serotonin 5‐HT transporter (5‐HTT) gene. A TATA‐like motif and several…”
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Genetic perspectives on the serotonin transporter: Serotonin: from the molecule to the clinic by MURPHY, Dennis L, QIAN LI, ENGEL, Sharon, WICHEMS, Christine, ANDREWS, Anne, LESCH, Klaus-Peter, UHL, George

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Brain serotonin neurotransmission: An overview and update with an emphasis on serotonin subsystem heterogeneity, multiple receptors, interactions with other neurotransmitter by Murphy, Dennis L, Andrews, Anne M, Wichems, Christine H, Li, Qian

“…Knowledge about serotonergic neurotransmission has been expanding rapidly. Recent research has delineated 15 molecularly different serotonin receptors and…”
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