Search Results - "Wicha, Sebastian"

Antimicrobial therapeutic drug monitoring in critically ill adult patients: a Position Paper by Abdul-Aziz, Mohd H., Alffenaar, Jan-Willem C., Bassetti, Matteo, Bracht, Hendrik, Dimopoulos, George, Marriott, Deborah, Neely, Michael N., Paiva, Jose-Artur, Pea, Federico, Sjovall, Fredrik, Timsit, Jean F., Udy, Andrew A., Wicha, Sebastian G., Zeitlinger, Markus, De Waele, Jan J., Roberts, Jason A.

“…Purpose This Position Paper aims to review and discuss the available data on therapeutic drug monitoring (TDM) of antibacterials, antifungals and antivirals in…”
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From Therapeutic Drug Monitoring to Model‐Informed Precision Dosing for Antibiotics by Wicha, Sebastian G., Märtson, Anne‐Grete, Nielsen, Elisabet I., Koch, Birgit C.P., Friberg, Lena E., Alffenaar, Jan‐Willem, Minichmayr, Iris K.

“…Therapeutic drug monitoring (TDM) and model‐informed precision dosing (MIPD) have evolved as important tools to inform rational dosing of antibiotics in…”
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Optimized Rhombic Experimental Dynamic Checkerboard Designs to Elucidate Pharmacodynamic Drug Interactions of Antibiotics by Kroemer, Niklas, Aubry, Romain, Couet, William, Grégoire, Nicolas, Wicha, Sebastian G.

“…Purpose Quantification of pharmacodynamic interactions is key in combination therapies, yet conventional checkerboard experiments with up to 10 by 10…”
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Contact-Biocide TiO2 Surfaces by Surface-Initiated Atom Transfer Radical Polymerization with Chemically Stable Phosphonate Initiators by Zorn, Eilika, Knaack, J. Iven H., Burmeister, Nils, Scharnagl, Nico, Rohnke, Marcus, Wicha, Sebastian G., Maison, Wolfgang

“…Surface-initiated atom transfer radical polymerization (SI-ATRP) is a powerful tool for grafting functional polymers from metal surfaces. It depends on the…”
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Evaluation of in vitro pharmacodynamic drug interactions of ceftazidime/avibactam and fosfomycin in Escherichia coli by Kroemer, Niklas, Martens, Miklas, Decousser, Jean-Winoc, Grégoire, Nicolas, Nordmann, Patrice, Wicha, Sebastian G

“…Abstract Background Combination therapy can increase efficacy of antibiotics and prevent emergence of resistance. Ceftazidime/avibactam and fosfomycin may be…”
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An improved PKPD modeling approach to characterize the pharmacodynamic interaction over time between ceftazidime/avibactam and colistin from in vitro time-kill experiments against multidrug-resistant Klebsiella pneumoniae isolates by Aubry, Romain, Buyck, Julien, Prouvensier, Laure, Decousser, Jean-Winoc, Nordmann, Patrice, Wicha, Sebastian G., Marchand, Sandrine, Grégoire, Nicolas

“…In contrast to the checkerboard method, bactericidal experiments [time-kill curves (TKCs)] allow an assessment of pharmacodynamic (PD) interactions over time…”
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Drug Combination Modeling: Methods and Applications in Drug Development by Pearson, Rachael A., Wicha, Sebastian G., Okour, Malek

“…Combination therapies have become increasingly researched and used in the treatment and management of complex diseases due to their ability to increase the…”
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Individualised dosing of antibiotics in ICU patients: timing, target and model selection matter by Liebchen, Uwe, Briegel, Josef, Brinkmann, Alexander, Frey, Otto, Wicha, Sebastian G.

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A general pharmacodynamic interaction model identifies perpetrators and victims in drug interactions by Wicha, Sebastian G., Chen, Chunli, Clewe, Oskar, Simonsson, Ulrika S. H.

“…Assessment of pharmacodynamic (PD) drug interactions is a cornerstone of the development of combination drug therapies. To guide this venture, we derive a…”
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Assessing parameter uncertainty in small-n pharmacometric analyses: value of the log-likelihood profiling-based sampling importance resampling (LLP-SIR) technique by Broeker, Astrid, Wicha, Sebastian G.

“…Assessing parameter uncertainty is a crucial step in pharmacometric workflows. Small datasets with ten or fewer subjects appear regularly in drug development…”
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Simultaneous determination and stability studies of linezolid, meropenem and vancomycin in bacterial growth medium by high-performance liquid chromatography by Wicha, Sebastian G., Kloft, Charlotte

“…[Display omitted] •Simultaneous quantification of linezolid, meropenem and vancomycin in growth medium.•Simple, rapid sample treatment and flexible gradient…”
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Impact of Key Components of Intensified Ceftaroline Dosing on Pharmacokinetic/Pharmacodynamic Target Attainment by Minichmayr, Iris K., Wicha, Sebastian G., Matzneller, Peter, Kloft, Charlotte, Zeitlinger, Markus

“…Background and Objective Ceftaroline fosamil is a β-lactam antibiotic approved as a 600 mg twice daily dose (≤1 h infusion, ‘standard dosing’) or a 600 mg…”
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Population pharmacokinetics and target attainment analysis of linezolid in multidrug‐resistant tuberculosis patients by Tietjen, Anna K., Kroemer, Niklas, Cattaneo, Dario, Baldelli, Sara, Wicha, Sebastian G.

“…Aim This study investigates the pharmacokinetic/pharmacodynamic (PK/PD) target attainment of linezolid in patients infected with multidrug‐resistant (MDR)…”
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Low-Fouling and Antibacterial Polymer Brushes via Surface-Initiated Polymerization of a Mixed Zwitterionic and Cationic Monomer by Burmeister, Nils, Zorn, Eilika, Preuss, Lena, Timm, Donovan, Scharnagl, Nico, Rohnke, Marcus, Wicha, Sebastian G., Streit, Wolfgang R., Maison, Wolfgang

“…The use of surface-grafted polymer brushes with combined low-fouling and antibacterial functionality is an attractive strategy to fight biofilm formation. This…”
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A dosing nomograph for cerebrospinal fluid penetration of meropenem applied by continuous infusion in patients with nosocomial ventriculitis by König, Christina, Grensemann, Jörn, Czorlich, Patrick, Schlemm, Eckhard, Kluge, Stefan, Wicha, Sebastian G.

“…In difficult-to-treat infections such as nosocomial ventriculitis, meropenem exposure in the infected compartment is often uncertain but crucial for…”
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Pharmacokinetics and pharmacological target attainment of standard temocillin dosing in non-critically ill patients with complicated urinary tract infections by Wijnant, Gert-Jan, Ngougni Pokem, Perrin, Coessens, Marie, Cottone, Eleonora, Ermtraud, Julian, Goeman, Lieven, Vervaeke, Steven, Wicha, Sebastian G, Van Bambeke, Françoise

“…Abstract Objectives Temocillin, a carbapenem-sparing β-lactam antibiotic, is commonly used at the standard 4 g/day dosage for treating complicated urinary…”
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Operational characteristics of full random effects modelling (‘frem’) compared to stepwise covariate modelling (‘scm’) by Amann, Lisa F., Wicha, Sebastian G.

“…An adequate covariate selection is a key step in population pharmacokinetic modelling. In this study, the automated stepwise covariate modelling technique…”
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A Machine Learning Approach to Predict Interdose Vancomycin Exposure by Bououda, Mehdi, Uster, David W., Sidorov, Egor, Labriffe, Marc, Marquet, Pierre, Wicha, Sebastian G., Woillard, Jean-Baptiste

“…Introduction Estimation of vancomycin area under the curve (AUC) is challenging in the case of discontinuous administration. Machine learning approaches are…”
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A Model Averaging/Selection Approach Improves the Predictive Performance of Model‐Informed Precision Dosing: Vancomycin as a Case Study by Uster, David W., Stocker, Sophie L., Carland, Jane E., Brett, Jonathan, Marriott, Deborah J.E., Day, Richard O., Wicha, Sebastian G.

“…Many important drugs exhibit substantial variability in pharmacokinetics and pharmacodynamics leading to a loss of the desired clinical outcomes or significant…”
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Contact-Biocide TiO 2 Surfaces by Surface-Initiated Atom Transfer Radical Polymerization with Chemically Stable Phosphonate Initiators by Zorn, Eilika, Knaack, J Iven H, Burmeister, Nils, Scharnagl, Nico, Rohnke, Marcus, Wicha, Sebastian G, Maison, Wolfgang

“…Surface-initiated atom transfer radical polymerization (SI-ATRP) is a powerful tool for grafting functional polymers from metal surfaces. It depends on the…”
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