Search Results - "Wiberg, Finn C."

Crystal structure of human dipeptidyl peptidase IV/CD26 in complex with a substrate analog by Rasmussen, Hanne B, Branner, Sven, Wiberg, Finn C, Wagtmann, Nicolai

“…Dipeptidyl peptidase IV (DPP-IV/CD26) is a multifunctional type II transmembrane serine peptidase. This enzyme contributes to the regulation of various…”
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Consistent manufacturing and quality control of a highly complex recombinant polyclonal antibody product for human therapeutic use by Frandsen, Torben P., Næsted, Henrik, Rasmussen, Søren K., Hauptig, Peter, Wiberg, Finn C., Rasmussen, Lone Kjær, Jensen, Anne Marie Valentin, Persson, Pia, Wikén, Margareta, Engström, Anders, Jiang, Yun, Thorpe, Susan J., Förberg, Cecilia, Tolstrup, Anne B.

“…The beneficial effect of antibody therapy in human disease has become well established mainly for the treatment of cancer and immunological disorders. The…”
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Production of target-specific recombinant human polyclonal antibodies in mammalian cells by Wiberg, Finn C., Rasmussen, Søren K., Frandsen, Torben P., Rasmussen, Lone K., Tengbjerg, Kaja, Coljee, Vincent W., Sharon, Jacqueline, Yang, Chiou-Ying, Bregenholt, Søren, Nielsen, Lars S., Haurum, John S., Tolstrup, Anne B.

“…We describe the expression and consistent production of a first target‐specific recombinant human polyclonal antibody. An anti‐Rhesus D recombinant polyclonal…”
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Alanine Scanning Mutagenesis of Insulin by Kristensen, Claus, Kjeldsen, Thomas, Wiberg, Finn C., Schäffer, Lauge, Hach, Morten, Havelund, Svend, Bass, Joseph, Steiner, Donald F., Andersen, Asser S.

“…Alanine scanning mutagenesis has been used to identify specific side chains of insulin which strongly influence binding to the insulin receptor. A total of 21…”
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Discovery and Structure−Activity Relationship of the First Non-Peptide Competitive Human Glucagon Receptor Antagonists by Madsen, Peter, Knudsen, Lotte B, Wiberg, Finn C, Carr, Richard D

“…The first non-peptide competitive human glucagon receptor antagonist, 2-(benzimidazol-2-ylthio)-1-(3,4-dihydroxyphenyl)-1-ethanone, NNC 92-1687 (2), is…”
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Changing the insulin receptor to possess insulin-like growth factor I ligand specificity by Andersen, Asser S, Kjeldsen, Thomas, Wiberg, Finn C, Christensen, Per Michael, Skou Rasmussen, Jesper, Norris, Kjeld, Bach Moeller, Karin, Moeller, Niels Peter H

“…To examine the role of the N-terminal part of the insulin-like growth factor I (IGF-I) receptor and insulin receptor in determining ligand specificity, we…”
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Characterization of recombinant human HBP/CAP37/azurocidin, a pleiotropic mediator of inflammation-enhancing LPS-induced cytokine release from monocytes by Rasmussen, Poul B., Bjørn, Søren, Hastrup, Sven, Nielsen, Per F., Norris, Kjeld, Thim, Lars, Wiberg, Finn C., Flodgaard, Hans

“…Neutrophil-derived heparin-binding protein (HBP) is a strong chemoattractant for monocytes. We report here for the first time the expression of recombinant…”
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Specificity of Insulin and Insulin-like Growth Factor I Receptors Investigated using Chimeric Mini-Receptors by Kristensen, Claus, Wiberg, Finn C., Andersen, Asser S.

“…We have investigated the role of the C-terminal of the α-subunit in the insulin receptor family by characterizing chimeric mini-receptor constructs comprising…”
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Identification of a calcium binding site in the protease domain of human blood coagulation factor VII: evidence for its role in factor VII - tissue factor interaction by Wildgoose, Peter, Foster, Don, Schioedt, Jakob, Wiberg, Finn C, Birktoft, Jens J, Petersen, Lars C

“…Previous studies have identified a putative calcium binding site involving two glutamic acid residues located in the protease domain of coagulation factor IX…”
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Expression and Characterization of a 70-kDa Fragment of the Insulin Receptor That Binds Insulin by Kristensen, Claus, Wiberg, Finn C., Schäffer, Lauge, Andersen, Asser S.

“…In order to characterize regions of the insulin receptor that are essential for ligand binding and possibly identify a smaller insulin-binding fragment of the…”
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Specificity of insulin and insulin-like growth factor I receptors investigated using chimeric mini-receptors. Role of C-terminal of receptor alpha subunit by Kristensen, C, Wiberg, F C, Andersen, A S

“…We have investigated the role of the C-terminal of the alpha-subunit in the insulin receptor family by characterizing chimeric mini-receptor constructs…”
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Sustained signalling from the insulin receptor after stimulation with insulin analogues exhibiting increased mitogenic potency by Hansen, B F, Danielsen, G M, Drejer, K, Sørensen, A R, Wiberg, F C, Klein, H H, Lundemose, A G

“…The metabolic and mitogenic potencies of six different insulin analogues were determined by measuring glucose transport in primary adipocytes and DNA synthesis…”
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Selective Down-regulation of the Insulin Receptor Signal by Protein-tyrosine Phosphatases α and by M⊘ller, Niels Peter H., M⊘ller, Karin B., Lammers, Reiner, Kharitonenkov, Alexei, Hoppe, Edmund, Wiberg, Finn C., Sures, Irmi, Ullrich, Axel

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Expression and characterization of a 70-kDa fragment of the insulin receptor that binds insulin. Minimizing ligand binding domain of the insulin receptor by Kristensen, C, Wiberg, F C, Schäffer, L, Andersen, A S

“…In order to characterize regions of the insulin receptor that are essential for ligand binding and possibly identify a smaller insulin-binding fragment of the…”
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The Ligand Specificities of the Insulin Receptor and the Insulin-Like Growth Factor I Receptor Reside in Different Regions of a Common Binding Site by Kjeldsen, Thomas, Andersen, Asser S., Wiberg, Finn C., Rasmussen, Jesper Skou, Schaffer, Lauge, Balschmidt, Per, Moller, Karin Bach, Niels Peter H. Moller

“…To identify the region(s) of the insulin receptor and the insulin-like growth factor I (IGF-I) receptor responsible for ligand specificity (high-affinity…”
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Human plasma and recombinant factor VII. Characterization of O-glycosylations at serine residues 52 and 60 and effects of site-directed mutagenesis of serine 52 to alanine by BJOERN, S, FOSTER, D. C, THIM, L, WIBERG, F. C, CHRISTENSEN, M, KOMIYAMA, Y, PEDERSEN, A. H, KISIEL, W

“…Factor VII is a multidomain, vitamin K-dependent plasma glycoprotein that participates in the extrinsic pathway of blood coagulation. Earlier studies…”
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Recombinant human extrinsic pathway inhibitor. Production, isolation, and characterization of its inhibitory activity on tissue factor-initiated coagulation reactions by Pedersen, A H, Nordfang, O, Norris, F, Wiberg, F C, Christensen, P M, Moeller, K B, Meidahl-Pedersen, J, Beck, T C, Norris, K, Hedner, U

“…Previous studies have shown that extrinsic pathway inhibitor (EPI) is an effective inhibitor of factor Xa alone or factor VIIa-tissue factor complex in the…”
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Identification of determinants that confer ligand specificity on the insulin receptor by Andersen, A S, Kjeldsen, T, Wiberg, F C, Vissing, H, Schäffer, L, Rasmussen, J S, De Meyts, P, Møller, N P

“…We have previously shown, using truncated soluble recombinant receptors, that substituting the 62 N-terminal amino acids of the alpha subunit from the…”
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Immobilized insulin for high capacity affinity chromatography of insulin receptors by MARKUSSEN, J, HALSTRØM, J, WIBERG, F. C, SCHÄFFER, L

“…Insulin receptors can be purified by affinity chromatography on immobilized insulin, but published methods all suffer from a rather low capacity of the…”
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Chimeric receptors indicate that phenylalanine 39 is a major contributor to insulin specificity of the insulin receptor by Kjeldsen, T, Wiberg, F C, Andersen, A S

“…The exact nature of how the insulin molecule interacts with the insulin receptor is obscure although chimeric receptors have shown that the ligand specificity…”
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