The genetic basis of high-carbohydrate and high-monosodium glutamate diet related to the increase of likelihood of type 2 diabetes mellitus: a review

The genetic basis of high-carbohydrate and high-monosodium glutamate diet related to the increase of likelihood of type 2 diabetes mellitus: a review

Diabetes is one of the most common metabolic diseases. Aside from the genetic factor, previous studies stated that other factors such as environment, lifestyle, and paternal–maternal condition play critical roles in diabetes through DNA methylation in specific areas of the genome. One of diabetic ca...

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Bibliographic Details
Published in:Endocrine Vol. 69; no. 1; pp. 18 - 29
Main Authors: Nathanael, Joshua, Harsono, Hans Cristian Adhinatya, Wibawa, Aubrey Druce, Suardana, Putu, Vianney, Yoanes Maria, Dwi Putra, Sulistyo Emantoko
Format: Journal Article
Language:English
Published: New York Springer US 01-07-2020
Springer Nature B.V
Subjects:
Blood glucose
Carbohydrates
Diabetes
Diabetes mellitus (non-insulin dependent)
DNA methylation
Endocrinology
Gene expression
Genomes
High carbohydrate diet
High fat diet
Homeostasis
Humanities and Social Sciences
Hyperglycemia
Insulin
Internal Medicine
Medicine
Medicine & Public Health
Metabolic disorders
Metabolism
Monosodium glutamate
multidisciplinary
Pathophysiology
Protein turnover
Review
Science
Obesity
High carbohydrate
Insulin resistance
Type 2 diabetes mellitus
Monosodium glutamate
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Summary:Diabetes is one of the most common metabolic diseases. Aside from the genetic factor, previous studies stated that other factors such as environment, lifestyle, and paternal–maternal condition play critical roles in diabetes through DNA methylation in specific areas of the genome. One of diabetic cases is caused by insulin resistance and changing the homeostasis of blood glucose control so glucose concentration stood beyond normal rate (hyperglycemia). High fat diet has been frequently studied and linked to triggering diabetes. However, most Asians consume rice (or food with high carbohydrate) and food with monosodium glutamate (MSG). This habit could lead to pathophysiology of type 2 diabetes mellitus (T2D). Previous studies showed that high-carbohydrate or high-MSG diet could change gene expression or modify protein activity in body metabolism. This imbalanced metabolism can lead to pleiotropic effects of diabetes mellitus. In this study, the authors have attempted to relate various changes in genes expression or protein activity to the high-carbohydrate and high-MSG-induced diabetes. The authors have also tried to relate several genes that contribute to pathophysiology of T2D and proposed several ideas of genes as markers and target for curing people with T2D. These are done by investigating altered activities of various genes that cause or are caused by diabetes. These genes are selected based on their roles in pathophysiology of T2D.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:1355-008X
1559-0100
DOI:10.1007/s12020-020-02256-x