Psoriasis and osteoporosis: a literature review
Psoriasis is a chronic inflammatory skin disease with complex comorbidities. Recent evidence has revealed how the inflammatory nature of psoriasis affects bone mineral density and may lead to osteoporosis. This review outlines the current understanding and advances on the association between psorias...
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| Published in: | Clinical and experimental dermatology Vol. 47; no. 8; pp. 1438 - 1445 |
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| Main Authors: | , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
England
Oxford University Press
01-08-2022
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| Subjects: | |
| Online Access: | Get full text |
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| Summary: | Psoriasis is a chronic inflammatory skin disease with complex comorbidities. Recent evidence has revealed how the inflammatory nature of psoriasis affects bone mineral density and may lead to osteoporosis. This review outlines the current understanding and advances on the association between psoriasis and osteoporosis. The current literature suggests an increased risk of osteopenia and osteoporosis in patients with extensive and chronic psoriasis, compounded by other lifestyle and genetic factors. It suggests that prophylactic measures such as vitamin D supplementation and increasing weight‐bearing exercises can help, but in patients with extensive psoriasis, prolonged systemic inflammation may require long‐term management. Although there have been many short‐term RCTs on the efficacy and safety of biologics in psoriasis, clinical studies looking at the long‐term effects of biologics, such as whether they might improve bone mineral density in these patients with psoriasis are yet to be conducted.
This review aims to determine the relationship between psoriasis and osteoporosis through an evaluation of the current literature by assessing the prevalence of osteopenia and osteoporosis in patients with psoriasis. Several case–control and cross‐sectional studies unveiled an association between psoriasis and osteoporosis, whereas other studies found no clear evidence. In the future, more robust and larger sample studies are required to address these limitations and subsequently substantiate these results. |
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| Bibliography: | DW and AW contributed equally to this work and should be considered joint first authors. ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 |
| ISSN: | 0307-6938 1365-2230 |
| DOI: | 10.1111/ced.15174 |