Search Results - "Whyte, Moira K"

The identification of markers of macrophage differentiation in PMA-stimulated THP-1 cells and monocyte-derived macrophages by Daigneault, Marc, Preston, Julie A, Marriott, Helen M, Whyte, Moira K B, Dockrell, David H

“…Differentiated macrophages are the resident tissue phagocytes and sentinel cells of the innate immune response. The phenotype of mature tissue macrophages…”
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Genome-Wide Association Study of Susceptibility to Idiopathic Pulmonary Fibrosis by Allen, Richard J, Guillen-Guio, Beatriz, Oldham, Justin M, Ma, Shwu-Fan, Dressen, Amy, Paynton, Megan L, Kraven, Luke M, Obeidat, Ma'en, Li, Xuan, Ng, Michael, Braybrooke, Rebecca, Molina-Molina, Maria, Hobbs, Brian D, Putman, Rachel K, Sakornsakolpat, Phuwanat, Booth, Helen L, Fahy, William A, Hart, Simon P, Hill, Mike R, Hirani, Nik, Hubbard, Richard B, McAnulty, Robin J, Millar, Ann B, Navaratnam, Vidyia, Oballa, Eunice, Parfrey, Helen, Saini, Gauri, Whyte, Moira K B, Zhang, Yingze, Kaminski, Naftali, Adegunsoye, Ayodeji, Strek, Mary E, Neighbors, Margaret, Sheng, Xuting R, Gudmundsson, Gunnar, Gudnason, Vilmundur, Hatabu, Hiroto, Lederer, David J, Manichaikul, Ani, Newell, Jr, John D, O'Connor, George T, Ortega, Victor E, Xu, Hanfei, Fingerlin, Tasha E, Bossé, Yohan, Hao, Ke, Joubert, Philippe, Nickle, David C, Sin, Don D, Timens, Wim, Furniss, Dominic, Morris, Andrew P, Zondervan, Krina T, Hall, Ian P, Sayers, Ian, Tobin, Martin D, Maher, Toby M, Cho, Michael H, Hunninghake, Gary M, Schwartz, David A, Yaspan, Brian L, Molyneaux, Philip L, Flores, Carlos, Noth, Imre, Jenkins, R Gisli, Wain, Louise V

“…Idiopathic pulmonary fibrosis (IPF) is a complex lung disease characterized by scarring of the lung that is believed to result from an atypical response to…”
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Zebrafish as a model for the study of neutrophil biology by Henry, Katherine M., Loynes, Catherine A., Whyte, Moira K. B., Renshaw, Stephen A.

“…Review of Zebrafish as a tool complementing existing approaches for the study of neutrophil biology, along with the advantages and advances driven by this…”
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Hypoxia shapes the immune landscape in lung injury and promotes the persistence of inflammation by Mirchandani, Ananda S., Jenkins, Stephen J., Bain, Calum C., Sanchez-Garcia, Manuel A., Lawson, Hannah, Coelho, Patricia, Murphy, Fiona, Griffith, David M., Zhang, Ailiang, Morrison, Tyler, Ly, Tony, Arienti, Simone, Sadiku, Pranvera, Watts, Emily R., Dickinson, Rebecca. S., Reyes, Leila, Cooper, George, Clark, Sarah, Lewis, David, Kelly, Van, Spanos, Christos, Musgrave, Kathryn M., Delaney, Liam, Harper, Isla, Scott, Jonathan, Parkinson, Nicholas J., Rostron, Anthony J., Baillie, J. Kenneth, Clohisey, Sara, Pridans, Clare, Campana, Lara, Lewis, Philip Starkey, Simpson, A. John, Dockrell, David H., Schwarze, Jürgen, Hirani, Nikhil, Ratcliffe, Peter J., Pugh, Christopher W., Kranc, Kamil, Forbes, Stuart J., Whyte, Moira K. B., Walmsley, Sarah R.

“…Hypoxemia is a defining feature of acute respiratory distress syndrome (ARDS), an often-fatal complication of pulmonary or systemic inflammation, yet the…”
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Activation of hypoxia-inducible factor-1α (Hif-1α) delays inflammation resolution by reducing neutrophil apoptosis and reverse migration in a zebrafish inflammation model by Elks, Philip M., van Eeden, Fredericus J., Dixon, Giles, Wang, Xingang, Reyes-Aldasoro, Constantino Carlos, Ingham, Philip W., Whyte, Moira K.B., Walmsley, Sarah R., Renshaw, Stephen A.

“…The oxygen-sensing transcription factor hypoxia-inducible factor-1α (HIF-1α) plays a critical role in the regulation of myeloid cell function. The mechanisms…”
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Impaired Mitochondrial Microbicidal Responses in Chronic Obstructive Pulmonary Disease Macrophages by Bewley, Martin A, Preston, Julie A, Mohasin, Mohammed, Marriott, Helen M, Budd, Richard C, Swales, Julie, Collini, Paul, Greaves, David R, Craig, Ruth W, Brightling, Christopher E, Donnelly, Louise E, Barnes, Peter J, Singh, Dave, Shapiro, Steven D, Whyte, Moira K B, Dockrell, David H

“…Chronic obstructive pulmonary disease (COPD) is characterized by impaired clearance of pulmonary bacteria. The effect of COPD on alveolar macrophage (AM)…”
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TNF-related apoptosis-inducing ligand (TRAIL) regulates inflammatory neutrophil apoptosis and enhances resolution of inflammation by McGrath, Emmet E., Marriott, Helen M., Lawrie, Allan, Francis, Sheila E., Sabroe, Ian, Renshaw, Stephen A., Dockrell, David H., Whyte, Moira K. B.

“…The death ligand TRAIL plays a role in physiologic resolution of inflammation and exogenous TRAIL has potential therapeutic benefits in neutrophil‐dominant…”
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The Toll-like Receptor 3 L412F Polymorphism and Disease Progression in Idiopathic Pulmonary Fibrosis by O'DWYER, David N, ARMSTRONG, Michelle E, HIRANI, Nik, HOGABOAM, Cory M, DONNELLY, Seamas C, TRUJILLO, Glenda, COOKE, Gordon, KEANE, Michael P, FALLON, Padraic G, SIMPSON, A. John, MILLAR, Ann B, MCGRATH, Emmet E, WHYTE, Moira K

“…Idiopathic pulmonary fibrosis (IPF) is a fatal progressive interstitial pneumonia. The innate immune system provides a crucial function in the recognition of…”
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Differential Effects of p38, MAPK, PI3K or Rho Kinase Inhibitors on Bacterial Phagocytosis and Efferocytosis by Macrophages in COPD by Bewley, Martin A, Belchamber, Kylie B R, Chana, Kirandeep K, Budd, Richard C, Donaldson, Gavin, Wedzicha, Jadwiga A, Brightling, Christopher E, Kilty, Iain, Donnelly, Louise E, Barnes, Peter J, Singh, Dave, Whyte, Moira K B, Dockrell, David H

“…Pulmonary inflammation and bacterial colonization are central to the pathogenesis of chronic obstructive pulmonary disease (COPD). Defects in macrophage…”
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Delayed neutrophil apoptosis enhances NET formation in cystic fibrosis by Gray, Robert D, Hardisty, Gareth, Regan, Kate H, Smith, Maeve, Robb, Calum T, Duffin, Rodger, Mackellar, Annie, Felton, Jennifer M, Paemka, Lily, McCullagh, Brian N, Lucas, Christopher D, Dorward, David A, McKone, Edward F, Cooke, Gordon, Donnelly, Seamas C, Singh, Pradeep K, Stoltz, David A, Haslett, Christopher, McCray, Paul B, Whyte, Moira K B, Rossi, Adriano G, Davidson, Donald J

“…Cystic fibrosis (CF) lung disease is defined by large numbers of neutrophils and associated damaging products in the airway. Delayed neutrophil apoptosis is…”
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Hypoxia selectively inhibits respiratory burst activity and killing of Staphylococcus aureus in human neutrophils by McGovern, Naomi N, Cowburn, Andrew S, Porter, Linsey, Walmsley, Sarah R, Summers, Charlotte, Thompson, Alfred A R, Anwar, Sadia, Willcocks, Lisa C, Whyte, Moira K B, Condliffe, Alison M, Chilvers, Edwin R

“…Neutrophils play a central role in the innate immune response and a critical role in bacterial killing. Most studies of neutrophil function have been conducted…”
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Loss of the oxygen sensor PHD3 enhances the innate immune response to abdominal sepsis by Kiss, Judit, Mollenhauer, Martin, Walmsley, Sarah R, Kirchberg, Johanna, Radhakrishnan, Praveen, Niemietz, Thomas, Dudda, Johanna, Steinert, Gunnar, Whyte, Moira K B, Carmeliet, Peter, Mazzone, Massimiliano, Weitz, Jürgen, Schneider, Martin

“…Hypoxia and HIFs (HIF-1α and HIF-2α) modulate innate immune responses in the setting of systemic inflammatory responses and sepsis. The HIF prolyl hydroxylase…”
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Regulation of neutrophil senescence by microRNAs by Ward, Jon R, Heath, Paul R, Catto, James W, Whyte, Moira K B, Milo, Marta, Renshaw, Stephen A

“…Neutrophils are rapidly recruited to sites of tissue injury or infection, where they protect against invading pathogens. Neutrophil functions are limited by a…”
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Interleukin-1β Regulates CXCL8 Release and Influences Disease Outcome in Response to Streptococcus pneumoniae, Defining Intercellular Cooperation between Pulmonary Epithelial Cells and Macrophages by MARRIOTT, Helen M, GASCOYNE, Kate A, DOCKRELL, David H, GOWDA, Ravi, GEARY, Ian, NICKLIN, Martin J. H, LANNELLI, Francesco, POZZI, Gianni, MITCHELL, Timothy J, WHYTE, Moira K. B, SABROE, Ian

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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A zebrafish compound screen reveals modulation of neutrophil reverse migration as an anti-inflammatory mechanism by Robertson, Anne L, Holmes, Geoffrey R, Bojarczuk, Aleksandra N, Burgon, Joseph, Loynes, Catherine A, Chimen, Myriam, Sawtell, Amy K, Hamza, Bashar, Willson, Joseph, Walmsley, Sarah R, Anderson, Sean R, Coles, Mark C, Farrow, Stuart N, Solari, Roberto, Jones, Simon, Prince, Lynne R, Irimia, Daniel, Rainger, G Ed, Kadirkamanathan, Visakan, Whyte, Moira K B, Renshaw, Stephen A

“…Diseases of failed inflammation resolution are common and largely incurable. Therapeutic induction of inflammation resolution is an attractive strategy to…”
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Author Correction: Hypoxia shapes the immune landscape in lung injury and promotes the persistence of inflammation by Mirchandani, Ananda S., Jenkins, Stephen J., Bain, Calum C., Sanchez-Garcia, Manuel A., Lawson, Hannah, Coelho, Patricia, Murphy, Fiona, Griffith, David M., Zhang, Ailiang, Morrison, Tyler, Ly, Tony, Arienti, Simone, Sadiku, Pranvera, Watts, Emily R., Dickinson, Rebecca. S., Reyes, Leila, Cooper, George, Clark, Sarah, Lewis, David, Kelly, Van, Spanos, Christos, Musgrave, Kathryn M., Delaney, Liam, Harper, Isla, Scott, Jonathan, Parkinson, Nicholas J., Rostron, Anthony J., Baillie, J. Kenneth, Clohisey, Sara, Pridans, Clare, Campana, Lara, Lewis, Philip Starkey, Simpson, A. John, Dockrell, David H., Schwarze, Jürgen, Hirani, Nikhil, Ratcliffe, Peter J., Pugh, Christopher W., Kranc, Kamil, Forbes, Stuart J., Whyte, Moira K. B., Walmsley, Sarah R.

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Effective caspase inhibition blocks neutrophil apoptosis and reveals Mcl-1 as both a regulator and a target of neutrophil caspase activation by Wardle, David J, Burgon, Joseph, Sabroe, Ian, Bingle, Colin D, Whyte, Moira K B, Renshaw, Stephen A

“…Human tissue inflammation is terminated, at least in part, by the death of inflammatory neutrophils by apoptosis. The regulation of this process is therefore…”
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Pyocyanin Production by Pseudomonas aeruginosa Induces Neutrophil Apoptosis and Impairs Neutrophil-Mediated Host Defenses In Vivo by Allen, Lucy, Dockrell, David H, Pattery, Theresa, Lee, Daniel G, Cornelis, Pierre, Hellewell, Paul G, Whyte, Moira K. B

“…Clearance of neutrophils from inflamed sites is critical for resolution of inflammation, but pathogen-driven neutrophil apoptosis can impair host defenses. We…”
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Opsonic Phagocytosis in Chronic Obstructive Pulmonary Disease Is Enhanced by Nrf2 Agonists by Bewley, Martin A, Budd, Richard C, Ryan, Eilise, Cole, Joby, Collini, Paul, Marshall, Jennifer, Kolsum, Umme, Beech, Gussie, Emes, Richard D, Tcherniaeva, Irina, Berbers, Guy A M, Walmsley, Sarah R, Donaldson, Gavin, Wedzicha, Jadwiga A, Kilty, Iain, Rumsey, William, Sanchez, Yolanda, Brightling, Christopher E, Donnelly, Louise E, Barnes, Peter J, Singh, Dave, Whyte, Moira K B, Dockrell, David H

“…Previous studies have identified defects in bacterial phagocytosis by alveolar macrophages (AMs) in patients with chronic obstructive pulmonary disease (COPD),…”
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The Role of Toll-Like Receptors in the Regulation of Neutrophil Migration, Activation, and Apoptosis by Sabroe, Ian, Dower, Steven K., Whyte, Moira K. B.

“…Toll-like receptors (TLRs) playan essential role inthe detection of invading pathogens and in theinduction of host antimicrobial defenses. TLR4, the major…”
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