Search Results - "Whyte, Lauren S."

Endo‐lysosomal and autophagic dysfunction: a driving factor in Alzheimer's disease? by Whyte, Lauren S., Lau, Adeline A., Hemsley, Kim M., Hopwood, John J., Sargeant, Timothy J.

“…Alzheimer's disease (AD) is the most common cause of dementia, and its prevalence will increase significantly in the coming decades. Although important…”
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putative cannabinoid receptor GPR55 affects osteoclast function in vitro and bone mass in vivo by Whyte, Lauren S, Ryberg, Erik, Sims, Natalie A, Ridge, Susan A, Mackie, Ken, Greasley, Peter J, Ross, Ruth A, Rogers, Michael J

“…GPR55 is a G protein-coupled receptor recently shown to be activated by certain cannabinoids and by lysophosphatidylinositol (LPI). However, the physiological…”
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Identification of Novel GPR55 Modulators Using Cell-Impedance-Based Label-Free Technology by Morales, Paula, Whyte, Lauren S, Chicharro, Roberto, Gómez-Cañas, María, Pazos, M. Ruth, Goya, Pilar, Irving, Andrew J, Fernández-Ruiz, Javier, Ross, Ruth A, Jagerovic, Nadine

“…The orphan G protein-coupled receptor GPR55 has been proposed as a novel receptor of the endocannabinoid system. However, the validity of this categorization…”
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Reduction in open field activity in the absence of memory deficits in the AppNL−G−F knock-in mouse model of Alzheimer’s disease by Whyte, Lauren S., Hemsley, Kim M., Lau, Adeline A., Hassiotis, Sofia, Saito, Takashi, Saido, Takaomi C., Hopwood, John J., Sargeant, Timothy J.

“…•AppNL−G−F mice show reduced open field activity at six months of age.•Detection of memory deficits in six month AppNL−G−F mice may depend on…”
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Lysosomal gene Hexb displays haploinsufficiency in a knock-in mouse model of Alzheimer’s disease by Whyte, Lauren S., Fourrier, Célia, Hassiotis, Sofia, Lau, Adeline A., Trim, Paul J., Hein, Leanne K., Hattersley, Kathryn J., Bensalem, Julien, Hopwood, John J., Hemsley, Kim M., Sargeant, Timothy J.

“…Lysosomal network abnormalities are an increasingly recognised feature of Alzheimer’s disease (AD), which appear early and are progressive in nature. Sandhoff…”
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Variables influencing fluorimetric N-sulfoglucosamine sulfohydrolase (SGSH) activity measurement in brain homogenates by Whyte, Lauren S., Hopwood, John J., Hemsley, Kim M., Lau, Adeline A.

“…Deficient N-sulfoglucosamine sulfohydrolase (SGSH) enzyme activity causes mucopolysaccharidosis (MPS) type IIIA. A fluorimetric SGSH activity assay is commonly…”
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Lysosomal Dysregulation in the Murine AppNL-G-F/NL-G-F Model of Alzheimer’s Disease by Whyte, Lauren S., Hassiotis, Sofia, Hattersley, Kathryn J., Hemsley, Kim M., Hopwood, John J., Lau, Adeline A., Sargeant, Timothy J.

“…•LAMP1 accumulates at amyloid beta plaques in AppNL-G-F/NL-G-F (knock-in) mouse brain.•Lysosomal hydrolases are enriched at amyloid beta plaques in…”
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Lysosomal Dysregulation in the Murine App Model of Alzheimer’s Disease by Whyte, Lauren S., Hassiotis, Sofia, Hattersley, Kathryn J., Hemsley, Kim M., Hopwood, John J., Lau, Adeline A., Sargeant, Timothy J.

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A novel conditional Sgsh knockout mouse model recapitulates phenotypic and neuropathic deficits of Sanfilippo syndrome by Lau, Adeline A., King, Barbara M., Thorsen, Carly L., Hassiotis, Sofia, Beard, Helen, Trim, Paul J., Whyte, Lauren S., Tamang, Sarah J., Duplock, Stephen K., Snel, Marten F., Hopwood, John J., Hemsley, Kim M.

“…Mucopolysaccharidosis (MPS) type IIIA, or Sanfilippo syndrome, is a neurodegenerative lysosomal storage disorder caused by a deficiency of the lysosomal enzyme…”
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Cannabinoids and bone: endocannabinoids modulate human osteoclast function in vitro by Whyte, LS, Ford, L, Ridge, SA, Cameron, GA, Rogers, MJ, Ross, RA

“…BACKGROUND AND PURPOSE Both CB1 and CB2 cannabinoid receptors have been shown to play a role in bone metabolism. Crucially, previous studies have focussed on…”
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Lysosomal Dysregulation in the Murine App NL-G-F/NL-G-F Model of Alzheimer's Disease by Whyte, Lauren S, Hassiotis, Sofia, Hattersley, Kathryn J, Hemsley, Kim M, Hopwood, John J, Lau, Adeline A, Sargeant, Timothy J

“…Lysosomal network dysfunction is a prominent feature of Alzheimer's disease (AD). Although transgenic mouse models of AD are known to model some aspects of…”
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Reduction in open field activity in the absence of memory deficits in the App NL-G-F knock-in mouse model of Alzheimer's disease by Whyte, Lauren S, Hemsley, Kim M, Lau, Adeline A, Hassiotis, Sofia, Saito, Takashi, Saido, Takaomi C, Hopwood, John J, Sargeant, Timothy J

“…The recent development of knock-in mouse models of Alzheimer's disease provides distinct advantages over traditional transgenic mouse models that rely on…”
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