MRI demonstration of impairment of the blood-CSF barrier by glucose administration to the thiamin-deficient rat brain

Contrast-enhanced T 1 -weighted spin-echo magnetic resonance imaging (MRI) has demonstrated that Gd-diethylenetriaminepentaacetate (Gd-DTPA), which normally does not cross the blood-brain or blood-CSF barriers, does so approximately 40 min after administration of glucose to a vitamin B 1 deficient r...

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Bibliographic Details
Published in:	Magnetic resonance imaging Vol. 13; no. 4; pp. 555 - 561
Main Authors:	Zelaya, F.O., Rose, S.E., Nixon, P.F., Wholohan, B.T., Bower, A.J., Zimitat, C., Schoutrop, J., Doddrell, D.M.
Format:	Journal Article
Language:	English
Published:	New York, NY Elsevier Inc 1995 Elsevier Science
Subjects:	Animals Biological and medical sciences Blood-Brain Barrier - drug effects Blood-CSF barrier Brain - pathology Contrast Media - pharmacokinetics Female Gadolinium - pharmacokinetics Gadolinium DTPA Gd-diethylenetriaminepentaacetate (Gd-DTPA) Glucose - pharmacology Investigative techniques, diagnostic techniques (general aspects) Magnetic Resonance Imaging Medical sciences Miscellaneous. Technology Organometallic Compounds - pharmacokinetics Pentetic Acid - analogs & derivatives Pentetic Acid - pharmacokinetics Radiodiagnosis. Nmr imagery. Nmr spectrometry Rat brain Rats Rats, Wistar Thiamine Deficiency - pathology Thiamine Deficiency - physiopathology Vitamin B 1 deficiency Wernicke Encephalopathy - physiopathology Vitamin B 1 deficiency Gd-diethylenetriaminepentaacetate (Gd-DTPA) Rat brain Blood-CSF barrier Vertebrata Mammalia Rat Animal Rodentia Vitamin Gadolinium Glucose Blood brain barrier Nuclear magnetic resonance imaging Thiamin Brain (vertebrata)
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Summary:	Contrast-enhanced T 1 -weighted spin-echo magnetic resonance imaging (MRI) has demonstrated that Gd-diethylenetriaminepentaacetate (Gd-DTPA), which normally does not cross the blood-brain or blood-CSF barriers, does so approximately 40 min after administration of glucose to a vitamin B 1 deficient rat. The period of the onset of this blood-CSF or blood-brain barrier dysfunction coincides with our previous observations of accumulation of glutamate or glutamate derivatives following an equivalent glucose load under identical conditions of thiamin deficiency, consistent with a relationship between these two observations. The dysfunction was reversed when a thiamin deficient animal was made thiamin replete.
ISSN:	0730-725X 1873-5894
DOI:	10.1016/0730-725X(95)00020-H