Search Results - "Whittle, Marty"

Abstract B23: Reprogramming of the cancer kinome in response to targeted kinase inhibition by Duncan, James S., Whittle, Marty W., Graves, Lee M., Johnson, Gary L.

“…Kinases are members of a large dynamic and cooperative signaling network, which senses inhibition of key nodal kinases and induces compensatory responses that…”
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Kinome reprogramming response to MEK inhibition: A window-of-opportunity trial in triple-negative breast cancer (TNBC) by Johnson, Gary L., Amos, Keith D., Duncan, James S, Whittle, Marty, Zawistowki, Jon, Goulet, Dan, He, Xiaping, Noe, Jeanne, Perou, Charles M., Earp, Shelton, Carey, Lisa A.

“…Abstract only 512 Background: Targeted therapy (Rx) in TNBC is challenging due to heterogeneity and cancer cell kinome “reprogramming” in response to targeted…”
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Profiling the Kinome of Drug Resistant Chronic Myelogenous Leukemia by Cox, Nathan James, Zimmerman, Eric I., Dewar, Brian J., Duncan, James, Whittle, Marty, Jin, Jian, Frye, Stephen V., Johnson, Gary L., Graves, Lee M.

“…Kinases compose only two percent of the human genome; however, they represent some of the potentially most important new drug targets for cancer chemotherapy…”
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