Search Results - "Whittington, R A"

Hypothermia and Alzheimer's disease neuropathogenic pathways by Whittington, R A, Papon, M-A, Chouinard, F, Planel, E

“…Alzheimer's disease (AD) remains a major health problem, and accounts for 50 to 60% of all cases of dementia. The two histopathological hallmarks of AD are…”
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The comparative toxicity of cocaine and its metabolites in conscious rats by MORISHIMA, H. O, WHITTINGTON, R. A, ISO, A, COOPER, T. B

“…The metabolites of cocaine, benzoylecgonine and ecgonine methyl ester, have been considered pharmacologically inactive when administered systemically. However,…”
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The nitric oxide-cGMP system of the locus coeruleus and the hypnotic action of alpha-2 adrenergic agonists by Vulliemoz, Yvonne, Whittington, Robert A., Virag, Laszlo

“…Dexmedetomidine (Dex), a potent, selective alpha-2 adrenergic agonist, injected bilaterally directly into the locus coeruleus (LC), 7 μg/LC, or ip, 100 μg/kg,…”
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Interaction of the α-2 adrenergic- and opioid receptor with the cGMP system in the mouse cerebellum by Vulliemoz, Yvonne, Virag, Laszlo, Whittington, Robert A.

“…The α-2 adrenergic agonist dexmedetomidine (Dex), 3–300 μg/kg, i.p., decreased cerebellar cGMP in a dose-dependent manner. Fentanyl (F), an opioid agonist,…”
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Rapid opioid detoxification during general anesthesia: is death not a significant outcome? by Whittington, R A, Collins, E D, Kleber, H D

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The disposition of cocaethylene in rat maternal, placental, and fetal compartments by Morishima, Hisayo O., Whittington, Robert A., Zhang, Yi, Cooper, Thomas B.

“…Objective: The aim of this project was to examine the disposition of maternally administered cocaethylene in the fetus. Study Design: Pregnant rats with…”
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Calcium phosphate ceramics in bone tissue engineering: A review of properties and their influence on cell behavior by Samavedi, Satyavrata, Whittington, Abby R., Goldstein, Aaron S.

“…Calcium phosphate ceramics (CPCs) have been widely used as biomaterials for the regeneration of bone tissue because of their ability to induce osteoblastic…”
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Anesthesia-Assisted vs Buprenorphine- or Clonidine-Assisted Heroin Detoxification and Naltrexone Induction: A Randomized Trial by Collins, Eric D, Kleber, Herbert D, Whittington, Robert A, Heitler, Nicole E

“…CONTEXT Rapid opioid detoxification with opioid antagonist induction using general anesthesia has emerged as an expensive, potentially dangerous, unproven…”
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Pharmacokinetic considerations for the use of the ovine model in cocaine research by Morishima, H O, Whittington, R A

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Synthesis and biological activity of novel cephalosporins containing a (Z)-vinyl dimethylphosphonate group by Smith, P W, Chamiec, A J, Chung, G, Cobley, K N, Duncan, K, Howes, P D, Whittington, A R, Wood, M R

“…A series of cephalosporins containing a novel 7-[2-(Z)-(2-amino-thiazol-4- yl)-3-(dimethoxy-phosphoryl)-acryloylamino] group were prepared and their…”
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Dissociable influences of opiates and expectations on pain by Atlas, Lauren Y, Whittington, Robert A, Lindquist, Martin A, Wielgosz, Joe, Sonty, Nomita, Wager, Tor D

“…Placebo treatments and opiate drugs are thought to have common effects on the opioid system and pain-related brain processes. This has created excitement about…”
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Response of bone marrow stromal cells to graded co-electrospun scaffolds and its implications for engineering the ligament-bone interface by Samavedi, Satyavrata, Guelcher, Scott A, Goldstein, Aaron S, Whittington, Abby R

“…Abstract Biomaterial scaffolds with gradients in architecture, mechanical and chemical properties have the potential to improve the osseointegration of…”
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Dexmedetomidine decreases extracellular dopamine concentrations in the rat nucleus accumbens by Whittington, Robert A, Virag, Laszlo, Morishima, Hisayo O, Vulliemoz, Yvonne

“…The effects of dexmedetomidine, a highly selective α 2-adrenoceptor agonist, on extracellular dopamine (DA) concentrations in the nucleus accumbens of awake…”
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Highly sensitive chromatographic assay for dopamine determination during in vivo cerebral microdialysis in the rat by Virag, Laszlo, Whittington, Robert A

“…A highly sensitive, yet simple, isocratic high-performance liquid chromatographic (HPLC) assay with electrochemical detection (ED) for the determination of…”
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Best Practices for Postoperative Brain Health: Recommendations From the Fifth International Perioperative Neurotoxicity Working Group by Berger, Miles, Schenning, Katie J., Brown, Charles H., Deiner, Stacie G., Whittington, Robert A., Eckenhoff, Roderic G.

“…As part of the American Society of Anesthesiology Brain Health Initiative goal of improving perioperative brain health for older patients, over 30 experts met…”
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State of the clinical science of perioperative brain health: report from the American Society of Anesthesiologists Brain Health Initiative Summit 2018 by Mahanna-Gabrielli, Elizabeth, Schenning, Katie J, Eriksson, Lars I, Browndyke, Jeffrey N, Wright, Clinton B, Culley, Deborah J, Evered, Lis, Scott, David A, Wang, Nae Yah, Brown, 4th, Charles H, Oh, Esther, Purdon, Patrick, Inouye, Sharon, Berger, Miles, Whittington, Robert A, Price, Catherine C, Deiner, Stacie

“…Cognitive recovery after anaesthesia and surgery is a concern for older adults, their families, and caregivers. Reports of patients who were 'never the same'…”
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Dose-related differences in the distribution of cocaine in the maternal–fetoplacental compartments in rats by Morishima, Hisayo O, Okutomi, Toshiyuki, Whittington, Robert A, Cooper, Thomas B

“…Our goals were to examine whether a high dose of cocaine to causing CNS toxic manifestations in the pregnant rats influences the delivery of cocaine to the…”
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Novel inhibitors of influenza sialidases related to zanamivir. Heterocyclic replacements of the glycerol sidechain by Smith, Paul W., Whittington, Andrew R., Sollis, Steven L., Howes, Peter D., Taylor, Neil R.

“…A series of substituted 4-amino-4H-pyran-2-carboxylic acid 6-triazoles and oxadiazoles are described. The compounds are inhibitors of influenza virus…”
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Highly potent and selective heptapeptide antagonists of the neurokinin NK-2 receptor by McElroy, Andrew B, Clegg, Stephen P, Deal, Martyn J, Ewan, George B, Hagan, Russell M, Ireland, Simon J, Jordan, Christopher C, Porter, Barry, Ross, Barry C

“…Incorporation of D-Pro9 into substance P related peptides is known to enhance neurokinin NK-2 receptor agonist potency and selectivity with respect to other…”
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Sodium Nitroprusside Metabolism in Children by Kazim, Robert, Whittington, Robert A., Sun, Lena S.

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