Search Results - "Whittier, Sean K."

Conformational Motions Regulate Phosphoryl Transfer in Related Protein Tyrosine Phosphatases by Whittier, Sean K., Hengge, Alvan C., Loria, J. Patrick

“…Many studies have implicated a role for conformational motions during the catalytic cycle, acting to optimize the binding pocket or facilitate product release,…”
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The Shigella Type III Secretion System: An Overview from Top to Bottom by Muthuramalingam, Meenakumari, Whittier, Sean K, Picking, Wendy L, Picking, William D

“…comprises four species of human-restricted pathogens causing bacillary dysentery. While possesses multiple genetic loci contributing to virulence, a type III…”
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Immunogenicity and protective efficacy of nanoparticle formulations of L-SseB against Salmonella infection by Das, Sayan, Howlader, Debaki R, Lu, Ti, Whittier, Sean K, Hu, Gang, Sharma, Simran, Dietz, Zackary K, Ratnakaram, Siva S K, Varisco, David J, Ernst, Robert K, Picking, William D, Picking, Wendy L

“…, a Gram-negative pathogen, has over 2500 serovars that infect a wide range of hosts. In humans, causes typhoid or gastroenteritis and is a major public health…”
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Development of a Broadly Protective, Self-Adjuvanting Subunit Vaccine to Prevent Infections by Pseudomonas aeruginosa by Das, Sayan, Howlader, Debaki R, Zheng, Qi, Ratnakaram, Siva Sai Kumar, Whittier, Sean K, Lu, Ti, Keith, Johnathan D, Picking, William D, Birket, Susan E, Picking, Wendy L

“…Infections caused by the opportunistic pathogen can be difficult to treat due to innate and acquired antibiotic resistance and this is exacerbated by the…”
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Development of a nano-emulsion based multivalent protein subunit vaccine against Pseudomonas aeruginosa by Howlader, Debaki R, Mandal, Rahul Shubhra, Lu, Ti, Maiti, Suhrid, Dietz, Zackary K, Das, Sayan, Whittier, Sean K, Nagel, Aaron C, Biswas, Satabdi, Varisco, David J, Gardner, Francesca M, Ernst, Robert K, Picking, William D, Picking, Wendy L

“…(Pa) is an opportunistic bacterial pathogen responsible for severe hospital acquired infections in immunocompromised and elderly individuals. Emergence of…”
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Impact of the TLR4 agonist BECC438 on a novel vaccine formulation against Shigella spp by Lu, Ti, Das, Sayan, Howlader, Debaki R, Jain, Akshay, Hu, Gang, Dietz, Zackary K, Zheng, Qi, Ratnakaram, Siva Sai Kumar, Whittier, Sean K, Varisco, David J, Ernst, Robert K, Picking, William D, Picking, Wendy L

“…Shigellosis (bacillary dysentery) is a severe gastrointestinal infection with a global incidence of 90 million cases annually. Despite the severity of this…”
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Composition and Biophysical Properties of the Sorting Platform Pods in the Shigella Type III Secretion System by Tachiyama, Shoichi, Skaar, Ryan, Chang, Yunjie, Carroll, Brittany L, Muthuramalingam, Meenakumari, Whittier, Sean K, Barta, Michael L, Picking, Wendy L, Liu, Jun, Picking, William D

“…, causative agent of bacillary dysentery (shigellosis), uses a type III secretion system (T3SS) as its primary virulence factor. The T3SS injectisome delivers…”
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The L-DBF vaccine cross protects mice against different Shigella serotypes after prior exposure to the pathogen by Lu, Ti, Howlader, Debaki R, Das, Sayan, Dietz, Zackary K, Nagel, Aaron C, Whittier, Sean K, Picking, William D, Picking, Wendy L

“…Shigellosis is endemic to low- and middle-income regions of the world where children are especially vulnerable. In many cases, there are pre-existing…”
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Vaccination with a Protective Ipa Protein-Containing Nanoemulsion Differentially Alters the Transcriptomic Profiles of Young and Elderly Mice following Shigella Infection by Lu, Ti, Raju, Murugesan, Howlader, Debaki R, Dietz, Zackary K, Whittier, Sean K, Varisco, David J, Ernst, Robert K, Coghill, Lyndon M, Picking, William D, Picking, Wendy L

“…spp. are responsible for bacillary dysentery or shigellosis transmitted via the fecal-oral route, causing significant morbidity and mortality, especially among…”
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Reengineering Rate-Limiting, Millisecond Enzyme Motions by Introduction of an Unnatural Amino Acid by Watt, Eric D., Rivalta, Ivan, Whittier, Sean K., Batista, Victor S., Loria, J. Patrick

“…Rate-limiting millisecond motions in wild-type (WT) Ribonuclease A (RNase A) are modulated by histidine 48. Here, we incorporate an unnatural amino acid,…”
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The Structures of SctK and SctD from Pseudomonas aeruginosa Reveal the Interface of the Type III Secretion System Basal Body and Sorting Platform by Muthuramalingam, Meenakumari, Whittier, Sean K., Lovell, Scott, Battaile, Kevin P., Tachiyama, Shoichi, Johnson, David K., Picking, Wendy L., Picking, William D.

“…The first reported structure for a T3SS SctK protein family member was solved for PscK from Pseudomonas aeruginosa and this allowed for modeling of the…”
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H, ¹⁵N, and ¹³C backbone resonance assignments for the Yersinia protein tyrosine phosphatase YopH by Whittier, Sean K, Loria, J Patrick

“…YopH is a protein tyrosine phosphatase that functions as a required virulence factor in Yersinia. Here we report the backbone resonance assignments for a point…”
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super(1)H, super(15)N, and super(13)C backbone resonance assignments for the yersinia protein tyrosine phosphatase YopH by Whittier, Sean K, Loria, JPatrick

“…YopH is a protein tyrosine phosphatase that functions as a required virulence factor in Yersinia. Here we report the backbone resonance assignments for a point…”
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L-DBF Elicits Cross Protection Against Different Serotypes of Shigella spp by Lu, Ti, Das, Sayan, Howlader, Debaki R., Zheng, Qi, Ratnakaram, Siva Sai Kumar, Whittier, Sean K., Picking, William D., Picking, Wendy L.

“…Shigellosis is a severe diarrheal disease caused by members of the genus Shigella , with at least 80 million cases and 700,000 deaths annually around the…”
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1H, 15N, and 13C backbone resonance assignments for the yersinia protein tyrosine phosphatase YopH by Whittier, Sean K., Loria, J. Patrick

“…YopH is a protein tyrosine phosphatase that functions as a required virulence factor in Yersinia . Here we report the backbone resonance assignments for a…”
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sup 1^H, ^sup 15^N, and ^sup 13^C backbone resonance assignments for the yersinia protein tyrosine phosphatase YopH by Whittier, Sean K, Loria, J Patrick

“…YopH is a protein tyrosine phosphatase that functions as a required virulence factor in Yersinia. Here we report the backbone resonance assignments for a point…”
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