Search Results - "Whittern, David"

Concise Construction of Novel Bridged Bicyclic Lactams by Sequenced Ugi/RCM/Heck Reactions by Ribelin, Timothy P, Judd, Andrew S, Akritopoulou-Zanze, Irini, Henry, Rodger F, Cross, Jeffrey L, Whittern, David N, Djuric, Stevan W

“…Herein we report a concise protocol for the diastereoselective synthesis of novel bridged bicyclic lactams from commercially available components by the…”
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Diels-Alder Reactions of a Styrene-Isocyanate: Unexpected Formation of a Pyridinone and Uracil by A. Gfesser, Gregory, Whittern, David, D. Cowart, Marlon, Faghih, Ramin

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5-N-acetylardeemin, a novel heterocyclic compound which reverses multiple drug resistance in tumor cells. II. Isolation and elucidation of the structure of 5-N-acetylardeemin and two congeners by Hochlowski, J E, Mullally, M M, Spanton, S G, Whittern, D N, Hill, P, McAlpine, J B

“…A family of novel compounds has been detected and isolated following an assay for the attenuation of multiple drug resistance in tumor cells from the…”
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Isolation of 9-Dihydro-13-acetylbaccatin III from Taxus canadensis by Gunawardana, Geewananda P, Premachandran, Usha, Burres, Neal S, Whittern, David N, Henry, Rodger, Spanton, Stephen, McAlpine, James B

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The development of an NMR chemical shift prediction application with the accuracy necessary to grade proton NMR spectra for identity by Spanton, Stephen G., Whittern, David

“…We have developed an NMR chemical shift prediction system that enables high throughput automatic grading of NMR spectra. In support of high throughput…”
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Production of brominated tiacumicin derivatives by Hochlowski, J E, Jackson, M, Rasmussen, R R, Buko, A M, Clement, J J, Whittern, D N, McAlpine, J B

“…Several novel tiacumicin derivatives containing bromine have been produced by the addition of inorganic bromine to the fermentation both of Dactylosporangium…”
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Macquarimicins, microbial metabolites from Micromonospora. II. Isolation and structural elucidation by Hochlowski, J E, Mullally, M M, Henry, R, Whittern, D M, McAlpine, J B

“…A novel series of carbocyclic compounds has been isolated from two related Micromonospora cultures. The C-19 and C-22 macquarimicins represent different end…”
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Pacidamycins, a novel series of antibiotics with anti-Pseudomonas aeruginosa activity. II. Isolation and structural elucidation by Chen, R H, Buko, A M, Whittern, D N, McAlpine, J B

“…A novel class of antibiotics was isolated from cultures of Streptomyces coeruleorubidus strain AB 1183F-64. The antimicrobial activity of the pacidamycins is…”
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Fusacandins A and B; novel antifungal antibiotics of the papulacandin class from Fusarium sambucinum. II. Isolation and structural elucidation by Hochlowski, J E, Whittern, D N, Buko, A, Alder, L, McAlpine, J B

“…Two novel antifungal compounds of the papulacandin class, named fusacandins A and B, have been isolated from Fusarium sambucinum. Each compound contains two…”
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Simple aromatics identified with a NFAT-lacZ transcription assay for the detection of immunosuppressants by Burres, N S, Premachandran, U, Hoselton, S, Cwik, D, Hochlowski, J E, Ye, Q, Sunga, G N, Karwowski, J P, Jackson, M, Whittern, D N

“…Determination of the mechanism of action of FK506 and cyclosporin A has yielded new molecular targets involved in signal transduction during T cell activation…”
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Revised NMR assignments for rapamycin by McAlpine, J B, Swanson, S J, Jackson, M, Whittern, D N

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Calbistrins, novel antifungal agents produced by Penicillium restrictum. II. Isolation and elucidation of structure by Brill, G M, Chen, R H, Rasmussen, R R, Whittern, D N, McAlpine, J B

“…The novel antifungal agents, calbistrins A, B, C and D have been isolated from a strain of Penicillium restrictum (AB 1875C-28). The four congeners were…”
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Altromycins, novel pluramycin-like antibiotics. II. Isolation and elucidation of structure by Brill, G M, McAlpine, J B, Whittern, D N, Buko, A M

“…A novel complex of Gram-positive antibiotics was produced from the fermentation of an actinomycete culture AB 1246E-26. The antibiotics were recovered from the…”
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New Trichoverroids from Myrothecium verrucaria Isolated by High Speed Countercurrent Chromatography by Jarvis, Brace B, DeSilva, Tuley, McAlphine, James B, Swanson, Susan J, Whittern, David N

“…Three new double-bond isomers of the trichothecene trichoverrins (3, 4a and 4b) have been isolated, principally through the use of high speed countercurrent…”
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Dunaimycins, a new complex of spiroketal 24-membered macrolides with immunosuppressive activity. II. Isolation and elucidation of structures by Hochlowski, J E, Mullally, M M, Brill, G M, Whittern, D N, Buko, A M, Hill, P, McAlpine, J B

“…A novel complex of antifungal and immunosuppressant compounds has been isolated from the fermentation broth and mycelia of two strains of Streptomyces…”
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Aselacins, novel compounds that inhibit binding of endothelin to its receptor. II. Isolation and elucidation of structures by Hochlowski, J E, Hill, P, Whittern, D N, Scherr, M H, Rasmussen, R R, Dorwin, S A, McAlpine, J B

“…Three novel compounds, named the aselacins, which inhibit the binding of endothelin to its receptor have been isolated from two related Acremonium species of…”
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Tirandalydigin, a novel tetramic acid of the tirandamycin-streptolydigin type. II. Isolation and structural characterization by Brill, G M, McAlpine, J B, Whittern, D

“…Tirandalydigin a structurally unique hybrid of the tirandamycin-streptolydigin families of tetramic acid antibiotics has been isolated from the fermentation…”
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Altromycins E, F, G, H and I; additional novel components of the altromycin complex by Brill, G M, Jackson, M, Whittern, D N, Buko, A M, Hill, P, Chen, R H, McAlpine, J B

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Coloradocin, an antibiotic from a new Actinoplanes. II. Identity with luminamicin and elucidation of structure by Rasmussen, R R, Scherr, M H, Whittern, D N, Buko, A M, McAlpine, J B

“…Coloradocin was isolated from a fermentation broth by adsorption onto Amberlite XAD-2. The activity was eluted in MeOH and purified by gel filtration on…”
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New antibiotics from genetically engineered actinomycetes. I. 2-Norerythromycins, isolation and structural determinations by McAlpine, J B, Tuan, J S, Brown, D P, Grebner, K D, Whittern, D N, Buko, A, Katz, L

“…Novel macrolide antibiotics have been isolated from a genetically manipulated actinomycete. The major components produced have been isolated and identified as…”
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