Search Results - "Whittard, Toni"

Suppression of Glomerulonephritis in Lupus‐Prone NZB × NZW Mice by RN486, a Selective Inhibitor of Bruton's Tyrosine Kinase by Mina‐Osorio, Paola, LaStant, Jacob, Keirstead, Natalie, Whittard, Toni, Ayala, Julia, Stefanova, Stella, Garrido, Rosario, Dimaano, Nena, Hilton, Holly, Giron, Mario, Lau, Kai‐Yeung, Hang, Julie, Postelnek, Jennifer, Kim, Yong, Min, Soo, Patel, Alka, Woods, John, Ramanujam, Meera, DeMartino, Julie, Narula, Satwant, Xu, Daigen

“…Objective Bruton's tyrosine kinase (BTK) plays a critical role in B cell development and function. We recently described a selective BTK inhibitor, RN486, that…”
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Selective inhibition of spleen tyrosine kinase (SYK) with a novel orally bioavailable small molecule inhibitor, RO9021, impinges on various innate and adaptive immune responses: implications for SYK inhibitors in autoimmune disease therapy by Liao, Cheng, Hsu, Jonathan, Kim, Yong, Hu, Dong-Qing, Xu, Daigen, Zhang, Jun, Pashine, Achal, Menke, John, Whittard, Toni, Romero, Natasha, Truitt, Theresa, Slade, Michelle, Lukacs, Christine, Hermann, Johannes, Zhou, Mingyan, Lucas, Matthew, Narula, Satwant, DeMartino, Julie, Tan, Seng-Lai

“…Spleen tyrosine kinase (SYK) is a key integrator of intracellular signals triggered by activated immunoreceptors, including Bcell receptors (BCR) and Fc…”
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Discovery of Orally Active Carboxylic Acid Derivatives of 2-Phenyl-5-trifluoromethyloxazole-4-carboxamide as Potent Diacylglycerol Acyltransferase-1 Inhibitors for the Potential Treatment of Obesity and Diabetes by Qian, Yimin, Wertheimer, Stanley J, Ahmad, Mushtaq, Cheung, Adrian Wai-Hing, Firooznia, Fariborz, Hamilton, Matthew M, Hayden, Stuart, Li, Shiming, Marcopulos, Nicholas, McDermott, Lee, Tan, Jenny, Yun, Weiya, Guo, Liang, Pamidimukkala, Anjula, Chen, Yingsi, Huang, Kuo-Sen, Ramsey, Gwendolyn B, Whittard, Toni, Conde-Knape, Karin, Taub, Rebecca, Rondinone, Cristina M, Tilley, Jefferson, Bolin, David

“…Diacylglycerol acyltransferase-1 (DGAT-1) is the enzyme that catalyzes the final and committed step of triglyceride formation, namely, the acylation of…”
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Discovery and optimization of 2-phenyloxazole derivatives as diacylglycerol acyltransferase-1 inhibitors by Yun, Weiya, Ahmad, Mushtaq, Chen, Yingsi, Gillespie, Paul, Conde-Knape, Karin, Kazmer, Sonja, Li, Shiming, Qian, Yimin, Taub, Rebecca, Wertheimer, Stanley J., Whittard, Toni, Bolin, David

“…The discovery and SAR studies of a phenyloxazole based diacylglycerol acyltransferase-1 inhibitor are reported. The optimized compound 25 is orally available…”
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Identification of an Adamantyl Azaquinolone JNK Selective Inhibitor by Haynes, Nancy-Ellen, Scott, Nathan R, Chen, Li C, Janson, Cheryl A, Li, Jia Kui, Lukacs, Christine M, Railkar, Aruna, Tozzo, Effie, Whittard, Toni, Brown, Nicholas F, Cheung, Adrian Wai-Hing

“…3-[4-((1S,2S,3R,5S,7S)-5-Hydroxyadamantan-2-ylcarbamoyl)benzyl]-4-oxo-1-phenyl-1,4-dihydro-[1,8]naphthyridine-2-carboxylic acid methyl ester (4) was identified…”
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