Search Results - "Whittaker, Caroline"
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Potent, orally active inhibitors of lipoprotein-associated phospholipase A2: 1-(biphenylmethylamidoalkyl)-pyrimidones
Published in Bioorganic & medicinal chemistry letters (07-01-2002)Get full text
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N-1 substituted pyrimidin-4-ones: Novel, orally active inhibitors of lipoprotein-associated phospholipase A2
Published in Bioorganic & medicinal chemistry letters (20-11-2000)“…From two related series of 2-(alkylthio)-pyrimidones, a novel series of 1-((amidolinked)-alkyl)-pyrimidones has been designed as nanomolar inhibitors of human…”
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1-(Arylpiperazinylamidoalkyl)-pyrimidones : Orally active inhibitors of lipoprotein-associated phospholipase A2
Published in Bioorganic & medicinal chemistry letters (23-07-2001)Get full text
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Preparing Personnel for Deployment
Published in Prehospital and disaster medicine (01-04-2009)Get full text
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The identification of a potent, water soluble inhibitor of lipoprotein-associated phospholipase A2
Published in Bioorganic & medicinal chemistry letters (12-03-2001)“…Modification of the pyrimidone 5-substituent in a series of 1-((amidolinked)-alkyl)-pyrimidones, lipophilic inhibitors of lipoprotein-associated phospholipase…”
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Helping patients get back to work is vital for their health
Published in Nursing standard (30-04-2008)Get full text
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Opening up part three of nmc register will be confusing
Published in Nursing standard (02-01-2008)Get full text
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The discovery of potent and long-acting oral factor Xa inhibitors with tetrahydroisoquinoline and benzazepine P4 motifs
Published in Bioorganic & medicinal chemistry letters (15-03-2011)“…The discovery of potent and long-acting series of orally available factor Xa inhibitors with tetrahydroisoquinoline and benzazepine motifs is described. The…”
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Structure and property based design of factor Xa inhibitors: Pyrrolidin-2-ones with aminoindane and phenylpyrrolidine P4 motifs
Published in Bioorganic & medicinal chemistry letters (15-03-2011)“…The discovery of potent series of orally available factor Xa inhibitors with aminoindane and phenylpyrrolidine motifs is described. The rational design,…”
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Structure and property based design of factor Xa inhibitors: pyrrolidin-2-ones with monoaryl P4 motifs
Published in Bioorganic & medicinal chemistry letters (15-01-2010)“…The discovery of a potent series of orally available Factor Xa inhibitors with monoaryl P4 motifs is described. Structure and property based drug design was…”
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Leadership in Higher Education: Exploring the Disparity of African American Representation in Washington State Colleges
Published 01-01-2021“…The study reveals the barriers and challenges of African Americans during their ascendancy to senior-level leadership roles. The study addresses the problem of…”
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Dissertation -
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Potent, orally active inhibitors of lipoprotein-associated phospholipase A(2): 1-(biphenylmethylamidoalkyl)-pyrimidones
Published in Bioorganic & medicinal chemistry letters (07-01-2002)“…A series of 1-(biphenylmethylamidoalkyl)-pyrimidones has been designed as nanomolar inhibitors of recombinant lipoprotein-associated phospholipase A(2) with…”
Get full text
Journal Article -
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Potent, orally active inhibitors of lipoprotein-associated phospholipase A 2: 1-(biphenylmethylamidoalkyl)-pyrimidones
Published in Bioorganic & medicinal chemistry letters (2002)“…A series of 1-(biphenylmethylamidoalkyl)-pyrimidones has been designed as nanomolar inhibitors of recombinant lipoprotein-associated phospholipase A 2 with…”
Get full text
Journal Article -
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The discovery of SB-435495. A potent, orally active inhibitor of lipoprotein-associated phospholipase A(2) for evaluation in man
Published in Bioorganic & medicinal chemistry letters (16-09-2002)“…The introduction of a functionalised amido substituent into a series of 1-(biphenylmethylacetamido)-pyrimidones has given a series of inhibitors of recombinant…”
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The discovery of SB-435495
Published in Bioorganic & medicinal chemistry letters (01-09-2002)Get full text
Journal Article -
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The identification of a potent, water soluble inhibitor of lipoprotein-associated phospholipase A 2
Published in Bioorganic & medicinal chemistry letters (2001)“…Modification of the pyrimidone 5-substituent in a series of 1-((amidolinked)-alkyl)-pyrimidones, lipophilic inhibitors of lipoprotein-associated phospholipase…”
Get full text
Journal Article -
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Some oxidative addition reactions of triosmium clusters
Published 01-01-1994“…This thesis describes the chemistry of the triosmium carbonyl cluster [OS3(CO)10(MECN)2] with phosphorus ylides and with nitrogen heterocycles. The aim of the…”
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Dissertation -
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The discovery of SB-435495: A potent, orally active inhibitor of lipoprotein-Associated phospholipase A 2 for evaluation in man
Published in Bioorganic & medicinal chemistry letters (2002)“…The introduction of a functionalised amido substituent into a series of 1-(biphenylmethylacetamido)-pyrimidones has given a series of inhibitors of recombinant…”
Get full text
Journal Article -
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Studies of N-heterocyclic compounds with triosmium clusters: Formation of the heterocyclic-linked dicluster compound [Os 6( μ-H) 2( μ 3-C 6H 4N 3) 2(CO) 18]
Published in Journal of organometallic chemistry (01-08-1997)“…The cluster [Os 3(CO) 10(MeCN) 2] reacts with indazole (C 7H 6N 2) to give two isomeric products [0s 3( μ-H)( μ-C 7H 5N 2)(CO) 10] in which the five-membered…”
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Journal Article