Search Results - "Whitt, Jordan"
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Intestinal epithelial HDAC3 and MHC class II coordinate microbiota-specific immunity
Published in The Journal of clinical investigation (15-02-2023)“…Aberrant immune responses to resident microbes promote inflammatory bowel disease and other chronic inflammatory conditions. However, how microbiota-specific…”
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Dietary phytate primes epithelial antibacterial immunity in the intestine
Published in Frontiers in immunology (19-10-2022)“…Although diet has long been associated with susceptibility to infection, the dietary components that regulate host defense remain poorly understood. Here, we…”
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Microbiota Inhibit Epithelial Pathogen Adherence by Epigenetically Regulating C-Type Lectin Expression
Published in Frontiers in immunology (07-05-2019)“…Numerous bacterial pathogens infect the mammalian host by initially associating with epithelial cells that line the intestinal lumen. Recent work has revealed…”
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Epithelial Histone Deacetylase 3 Instructs Intestinal Immunity by Coordinating Local Lymphocyte Activation
Published in Cell reports (Cambridge) (09-05-2017)“…Mucosal tissues are constantly in direct contact with diverse beneficial and pathogenic microbes, highlighting the need for orchestrating complex…”
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Disruption of Epithelial HDAC3 in Intestine Prevents Diet-Induced Obesity in Mice
Published in Gastroenterology (New York, N.Y. 1943) (01-08-2018)“…Intestinal microbiota modulate metabolism and associate closely with epithelial cells in the intestine. In intestinal epithelial cells (IECs), histone…”
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Microbiota-derived metabolite promotes HDAC3 activity in the gut
Published in Nature (London) (01-10-2020)“…The coevolution of mammalian hosts and their beneficial commensal microbes has led to development of symbiotic host–microbiota relationships 1 . Epigenetic…”
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Commensal Fungi Recapitulate the Protective Benefits of Intestinal Bacteria
Published in Cell host & microbe (13-12-2017)“…Commensal intestinal microbes are collectively beneficial in preventing local tissue injury and augmenting systemic antimicrobial immunity. However, given the…”
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Epithelial MHC class II directs microbiota-specific intestinal immune homeostasis
Published in The Journal of immunology (1950) (01-05-2022)“…The intestinal microbiota is essential for instructing the host immune system, however, dysregulated immune responses to resident commensal microbes can…”
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Commensal segmented filamentous bacteria-derived retinoic acid primes host defense to intestinal infection
Published in Cell host & microbe (08-12-2021)“…Interactions between the microbiota and mammalian host are essential for defense against infection, but the microbial-derived cues that mediate this…”
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Cell type‐specific mechanisms coupling protease‐activated receptor‐1 to infectious colitis pathogenesis
Published in Journal of thrombosis and haemostasis (01-01-2020)“…Background Protease‐activated receptor‐1 (PAR‐1) plays a major role in multiple disease processes, including colitis. Understanding the mechanisms coupling…”
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635 - Intestinal Microbiota Direct an Epithelial Epigenetic Signature of Pediatric Crohn's Disease
Published in Gastroenterology (New York, N.Y. 1943) (01-05-2018)Get full text
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Microbiota-sensitive epigenetic signature predicts inflammation in Crohn's disease
Published in JCI insight (20-09-2018)“…Altered response to the intestinal microbiota strongly associates with inflammatory bowel disease (IBD); however, how commensal microbial cues are integrated…”
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Does Ta Low-grade Urothelial Carcinoma of the Bladder With Focal High-grade Features Carry Worse Prognosis? The Roswell Park Comprehensive Cancer Center Experience
Published in Urology (Ridgewood, N.J.) (01-11-2024)“…To describe the management and outcomes of patients with Ta predominantly low-grade urothelial carcinoma with focal high-grade features (FHG) (<5%), compared…”
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