Search Results - "Whitson, Ramon J."

Smoothened Variants Explain the Majority of Drug Resistance in Basal Cell Carcinoma by Atwood, Scott X., Sarin, Kavita Y., Whitson, Ramon J., Li, Jiang R., Kim, Geurim, Rezaee, Melika, Ally, Mina S., Kim, Jinah, Yao, Catherine, Chang, Anne Lynn S., Oro, Anthony E., Tang, Jean Y.

“…Advanced basal cell carcinomas (BCCs) frequently acquire resistance to Smoothened (SMO) inhibitors through unknown mechanisms. Here we identify SMO mutations…”
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Epigenetic targeting of Hedgehog pathway transcriptional output through BET bromodomain inhibition by Tang, Yujie, Gholamin, Sharareh, Schubert, Simone, Willardson, Minde I, Lee, Alex, Bandopadhayay, Pratiti, Bergthold, Guillame, Masoud, Sabran, Nguyen, Brian, Vue, Nujsaubnusi, Balansay, Brianna, Yu, Furong, Oh, Sekyung, Woo, Pamelyn, Chen, Spenser, Ponnuswami, Anitha, Monje, Michelle, Atwood, Scott X, Whitson, Ramon J, Mitra, Siddhartha, Cheshier, Samuel H, Qi, Jun, Beroukhim, Rameen, Tang, Jean Y, Wechsler-Reya, Rob, Oro, Anthony E, Link, Brian A, Bradner, James E, Cho, Yoon-Jae

“…Cancers dependent on hedgehog pathway signaling are susceptible to the BET bromodomain inhibitor JQ1. Hedgehog signaling drives oncogenesis in several cancers,…”
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AP-1 and TGFß cooperativity drives non-canonical Hedgehog signaling in resistant basal cell carcinoma by Yao, Catherine D., Haensel, Daniel, Gaddam, Sadhana, Patel, Tiffany, Atwood, Scott X., Sarin, Kavita Y., Whitson, Ramon J., McKellar, Siegen, Shankar, Gautam, Aasi, Sumaira, Rieger, Kerri, Oro, Anthony E.

“…Tumor heterogeneity and lack of knowledge about resistant cell states remain a barrier to targeted cancer therapies. Basal cell carcinomas (BCCs) depend on…”
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RAS/MAPK Activation Drives Resistance to Smo Inhibition, Metastasis, and Tumor Evolution in Shh Pathway-Dependent Tumors by Zhao, Xuesong, Ponomaryov, Tatyana, Ornell, Kimberly J, Zhou, Pengcheng, Dabral, Sukriti K, Pak, Ekaterina, Li, Wei, Atwood, Scott X, Whitson, Ramon J, Chang, Anne Lynn S, Li, Jiang, Oro, Anthony E, Chan, Jennifer A, Kelleher, Joseph F, Segal, Rosalind A

“…Aberrant Shh signaling promotes tumor growth in diverse cancers. The importance of Shh signaling is particularly evident in medulloblastoma and basal cell…”
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Noncanonical hedgehog pathway activation through SRF–MKL1 promotes drug resistance in basal cell carcinomas by Whitson, Ramon J, Lee, Alex, Urman, Nicole M, Mirza, Amar, Yao, Catherine Y, Brown, Alexander S, Li, Jiang R, Shankar, Gautam, Fry, Micah A, Atwood, Scott X, Lee, Eunice Y, Hollmig, S Tyler, Aasi, Sumaira Z, Sarin, Kavita Y, Scott, Matthew P, Epstein, Ervin H, Tang, Jean Y, Oro, Anthony E

“…A large proportion of basal cell carcinomas develop resistance independently of the canonical mutations in genes encoding hedgehog pathway components. An…”
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Loss of Primary Cilia Drives Switching from Hedgehog to Ras/MAPK Pathway in Resistant Basal Cell Carcinoma by Kuonen, François, Huskey, Noelle E., Shankar, Gautam, Jaju, Prajakta, Whitson, Ramon J., Rieger, Kerri E., Atwood, Scott X., Sarin, Kavita Y., Oro, Anthony E.

“…Basal cell carcinomas (BCCs) rely on Hedgehog (HH) pathway growth signal amplification by the microtubule-based organelle, the primary cilium. Despite naive…”
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Tumor-Derived Suppressor of Fused Mutations Reveal Hedgehog Pathway Interactions by Urman, Nicole M, Mirza, Amar, Atwood, Scott X, Whitson, Ramon J, Sarin, Kavita Y, Tang, Jean Y, Oro, Anthony E

“…The Hedgehog pathway is a potent regulator of cellular growth and plays a central role in the development of many cancers including basal cell carcinoma (BCC)…”
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Soil Primes the Seed: Epigenetic Landscape Drives Tumor Behavior by Whitson, Ramon J., Oro, Anthony E.

“…Whether invasive tumor phenotypes like EMT arise from oncogenic drivers or from priming of the pre-tumor cell of origin remains unknown. In this issue of Cell…”
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Growth differentiation factor-15 (GDF-15) suppresses in vitro angiogenesis through a novel interaction with connective tissue growth factor (CCN2) by Whitson, Ramon J., Lucia, Marshall Scott, Lambert, James R.

“…Growth differentiation factor‐15 (GDF‐15) and the CCN family member, connective tissue growth factor (CCN2), are associated with cardiac disease, inflammation,…”
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Advanced treatment for basal cell carcinomas by Atwood, Scott X, Whitson, Ramon J, Oro, Anthony E

“…Basal cell carcinomas (BCCs) are very common epithelial cancers that depend on the Hedgehog pathway for tumor growth. Traditional therapies such as surgical…”
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Reduced expression of GDF-15 is associated with atrophic inflammatory lesions of the prostate by Lambert, James R., Whitson, Ramon J., Iczkowski, Kenneth A., La Rosa, Francisco G., Smith, Maxwell L., Wilson, R. Storey, Smith, Elizabeth E., Torkko, Kathleen C., Gari, Hamid H., Lucia, M. Scott

“…BACKGROUND Accumulating evidence suggests that chronic prostatic inflammation may lead to prostate cancer development. Growth differentiation factor‐15…”
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“Patch”ing Up Our Tumor Signaling Knowledge by Atwood, Scott X., Whitson, Ramon J., Oro, Anthony E.

“…The tumor suppressor Patched1 (Ptch1) possesses well-described roles in regulating sonic hedgehog (SHH) signaling in the skin and preventing the formation of…”
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EPIGENETIC TARGETING OF HEDGEHOG PATHWAY TRANSCRIPTIONAL OUTPUT by Cho, Y.-J., Tang, Y., Schubert, S., Willardson, M., Bandopadhayay, P., Bergthold, G., Nguyen, B., Masoud, S., Vue, N., Balansay, B., Gholamin, S., Cheshier, S. H., Atwood, S. X., Whitson, R. J., Lee, A., Tang, J. Y., Qi, J., Beroukhim, R., Wechsler-Reya, R., Oro, A. E., Link, B., Bradner, J. E.

“…BACKGROUND: (blind field) METHODS: We used ligand and genetic activation of the Hedgehog pathway to study the effects of BET bromodomain inhibition on Hedgehog…”
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Non-canonical hedgehog pathway activation by MKL1/SRF promotes drug-resistance in basal cell carcinomas by Whitson, Ramon J., Lee, Alex, Urman, Nicole M., Mirza, Amar, Yao, Catherine Y., Brown, Alexander S., Li, Jiang R., Shankar, Gautam, Fry, Micah A., Atwood, Scott X., Hollmig, S. Tyler, Aasi, Sumaira Z., Sarin, Kavita Y., Epstein, Ervin H., Tang, Jean Y., Oro, Anthony E.

“…Hedgehog pathway-dependent cancers can escape smoothened (SMO) inhibition through canonical pathway mutations, however, 50% of resistant BCCs lack additional…”
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Abstract B6: Epigenetic regulation of Hedgehog pathway transcriptional output by BET bromodomain proteins by Tang, Yujie, Schubert, Simone, Qi, Jun, Nguyen, Brian, Masoud, Sabran, Vue, Nujsaunusi, Balansay, Brianna, Yu, Furong, Atwood, Scott X., Whitson, Ramon J., Ponnuswami, Anitha, Chen, Spencer, Gholamin, Sharareh, Pamelyn, Woo J., Monje-Diesseroth, Michelle, Oh, Sekyung, Lee, Alex, Tang, Jean Y., Wechsler-Reya, Rob, Oro, Anthony E., Bradner, James E., Cho, Yoon-Jae

“…Abstract Aberrant activation of Hedgehog signaling drives oncogenesis in several types of cancer. As a result, there has been significant interest in…”
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Abstract B60: Prostate-derived factor/macrophage inhibitory cytokine-1/nonsteroidal anti-inflammatory drug activated gene: A mediator of prostatic inflammation by Whitson, Ramon J., Genova, Erin, Torkko, Kathleen, Rosa, Francisco G. La, Kelly, Julie, Wilson, Storey, Lambert, James R., Lucia, Marshall Scott

“…Abstract Prostatic inflammation is recognized as a potential initiating and potentiating factor in the development of prostate cancer. Prostate derived factor…”
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