Search Results - "Whitson, J.S."

Attenuation of the neurotoxic effect of A beta amyloid peptide by apolipoprotein E by Whitson, J S, Mims, M P, Strittmatter, W J, Yamaki, T, Morrisett, J D, Appel, S H

“…Alzheimer's disease patients have increased frequency of apolipoprotein E allele c4, suggesting apoE4 is a risk factor determining disease. ApoE binds A beta…”
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Neurotoxicity of Aβ amyloid protein in vitro is not altered by calcium channel blockade by Whitson, J.S., Appel, S.H.

“…In cortical cultures, Aβ protein destabilizes calcium homeostasis, but direct neurotoxicity of Aβ is not observed. In hippocampal cultures, we and others find…”
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Rescue of injury-induced neurofilaments loss by BDNF gene transfection in primary septo-hippocampal cell cultures by Hayes, R.L., Yang, K., Whitson, J.S., Xue, J.J., Kampfl, A., Mu, X.S., Zhao, X., Faustinella, F., Clifton, G.L.

“…We employed primary septo-hippocampal cell cultures to determine the ability of liposome-mediated BDNF gene transfection to facilitate recovery of…”
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Calpain inhibitors reduce depolarization induced loss of tau protein in primary septo-hippocampal cultures by Kampfl, A., Whitson, J.S., Zhao, X., Posmantur, R., Clifton, G.L., Hayes, R.L.

“…We studied the effects of a 6-min potassium depolarization injury produced by 60 mM KCl and 1.8 mM or 5.8 mM extracellular CaCl 2 on tau protein levels in…”
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Brief potassium depolarization decreases levels of neurofilament proteins in CNS culture by Whitson, J.S., Kampfl, A., Zhao, X., Dixon, C.E., Hayes, R.L.

“…Little is known about the effects of brief potassium depolarization that occurs concurrently with transient ischemia, epilepsy and head trauma. To investigate…”
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Time course of neurofilament protein loss following depolarization-induced injury in CNS culture by Whitson, J.S., Kampfl, A., Zhao, X., Hayes, R.L.

“…In septo-hippocampal cell cultures, brief potassium depolarization produces calcium-dependent decreases in neurofilament proteins and loss of fine neuritic…”
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