Search Results - "Whitney, Paul"

Developing L2 Oral Proficiency through Synchronous CMC: Output, Working Memory, and Interlanguage Development by Payne, J. Scott, Whitney, Paul J.

“…A naturalistic experiment was conducted to test the hypothesis that synchronous computer-mediated communication (CMC) can indirectly improve L2 oral…”
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Spatiotemporally Distinct Interactions with Dendritic Cell Subsets Facilitates CD4+ and CD8+ T Cell Activation to Localized Viral Infection by Hor, Jyh Liang, Whitney, Paul G., Zaid, Ali, Brooks, Andrew G., Heath, William R., Mueller, Scott N.

“…The dynamics of when and where CD4+ T cells provide help for CD8+ T cell priming and which dendritic cells (DCs) activate CD4+ T cells in vivo after localized…”
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IL-17 Regulates Systemic Fungal Immunity by Controlling the Functional Competence of NK Cells by Bär, Eva, Whitney, Paul G., Moor, Kathrin, Reis e Sousa, Caetano, LeibundGut-Landmann, Salomé

“…Interleukin 17 (IL-17)-mediated immunity plays a key role in protection from fungal infections in mice and man. Here, we confirmed that mice deficient in the…”
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Genetic Tracing via DNGR-1 Expression History Defines Dendritic Cells as a Hematopoietic Lineage by Schraml, Barbara U., van Blijswijk, Janneke, Zelenay, Santiago, Whitney, Paul G., Filby, Andrew, Acton, Sophie E., Rogers, Neil C., Moncaut, Natalia, Carvajal, Jaime J., Reis e Sousa, Caetano

“…Mononuclear phagocytes are classified as macrophages or dendritic cells (DCs) based on cell morphology, phenotype, or select functional properties. However,…”
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Microbiota-Derived Short-Chain Fatty Acids Promote the Memory Potential of Antigen-Activated CD8+ T Cells by Bachem, Annabell, Makhlouf, Christina, Binger, Katrina J., de Souza, David P., Tull, Deidra, Hochheiser, Katharina, Whitney, Paul G., Fernandez-Ruiz, Daniel, Dähling, Sabrina, Kastenmüller, Wolfgang, Jönsson, Johanna, Gressier, Elise, Lew, Andrew M., Perdomo, Carolina, Kupz, Andreas, Figgett, William, Mackay, Fabienne, Oleshansky, Moshe, Russ, Brendan E., Parish, Ian A., Kallies, Axel, McConville, Malcolm J., Turner, Stephen J., Gebhardt, Thomas, Bedoui, Sammy

“…Interactions with the microbiota influence many aspects of immunity, including immune cell development, differentiation, and function. Here, we examined the…”
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NLRP3 inflammasome activation downstream of cytoplasmic LPS recognition by both caspase‐4 and caspase‐5 by Baker, Paul J., Boucher, Dave, Bierschenk, Damien, Tebartz, Christina, Whitney, Paul G., D'Silva, Damian B., Tanzer, Maria C., Monteleone, Mercedes, Robertson, Avril A. B., Cooper, Matthew A., Alvarez‐Diaz, Silvia, Herold, Marco J., Bedoui, Sammy, Schroder, Kate, Masters, Seth L.

“…Humans encode two inflammatory caspases that detect cytoplasmic LPS, caspase‐4 and caspase‐5. When activated, these trigger pyroptotic cell death and…”
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Syk signaling in dendritic cells orchestrates innate resistance to systemic fungal infection by Whitney, Paul G, Bär, Eva, Osorio, Fabiola, Rogers, Neil C, Schraml, Barbara U, Deddouche, Safia, LeibundGut-Landmann, Salomé, Reis e Sousa, Caetano

“…Host protection from fungal infection is thought to ensue in part from the activity of Syk-coupled C-type lectin receptors and MyD88-coupled toll-like…”
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Different patterns of peripheral migration by memory CD4+ and CD8+ T cells by Gebhardt, Thomas, Whitney, Paul G., Zaid, Ali, Mackay, Laura K., Brooks, Andrew G., Heath, William R., Carbone, Francis R., Mueller, Scott N.

“…T-cell migration is subset-specific T cells are crucial to immunity at surface tissues such as skin, which represent entry points for many infectious agents…”
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Type 1 conventional dendritic cells maintain and guide the differentiation of precursors of exhausted T cells in distinct cellular niches by Dähling, Sabrina, Mansilla, Ana Maria, Knöpper, Konrad, Grafen, Anika, Utzschneider, Daniel T., Ugur, Milas, Whitney, Paul G., Bachem, Annabell, Arampatzi, Panagiota, Imdahl, Fabian, Kaisho, Tsuneyasu, Zehn, Dietmar, Klauschen, Frederick, Garbi, Natalio, Kallies, Axel, Saliba, Antoine-Emmanuel, Gasteiger, Georg, Bedoui, Sammy, Kastenmüller, Wolfgang

“…Reinvigoration of exhausted CD8+ T (Tex) cells by checkpoint immunotherapy depends on the activation of precursors of exhausted T (Tpex) cells, but the local…”
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Cross-presentation of viral and self antigens by skin-derived CD103 + dendritic cells by Brooks, Andrew G, Caminschi, Irina, Shortman, Ken, Carbone, Francis R, Wojtasiak, Magdalena, Allan, Rhys S, Bedoui, Sammy, Waithman, Jason, Wakim, Linda, Heath, William R, Whitney, Paul G, Eidsmo, Liv

“…The functions of individual dendritic cell subsets in the skin are unclear. Heath and colleagues now show that langerin-positive CD103 + dermal dendritic cells…”
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The dendritic cell receptor DNGR-1 controls endocytic handling of necrotic cell antigens to favor cross-priming of CTLs in virus-infected mice by Zelenay, Santiago, Keller, Anna M, Whitney, Paul G, Schraml, Barbara U, Deddouche, Safia, Rogers, Neil C, Schulz, Oliver, Sancho, David, Reis e Sousa, Caetano

“…DNGR-1 (CLEC9A) is a receptor for necrotic cells required by DCs to cross-prime CTLs against dead cell antigens in mice. It is currently unknown how DNGR-1…”
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Flexible Usage and Interconnectivity of Diverse Cell Death Pathways Protect against Intracellular Infection by Doerflinger, Marcel, Deng, Yexuan, Whitney, Paul, Salvamoser, Ranja, Engel, Sven, Kueh, Andrew J., Tai, Lin, Bachem, Annabell, Gressier, Elise, Geoghegan, Niall D., Wilcox, Stephen, Rogers, Kelly L., Garnham, Alexandra L., Dengler, Michael A., Bader, Stefanie M., Ebert, Gregor, Pearson, Jaclyn S., De Nardo, Dominic, Wang, Nancy, Yang, Chenying, Pereira, Milton, Bryant, Clare E., Strugnell, Richard A., Vince, James E., Pellegrini, Marc, Strasser, Andreas, Bedoui, Sammy, Herold, Marco J.

“…Programmed cell death contributes to host defense against pathogens. To investigate the relative importance of pyroptosis, necroptosis, and apoptosis during…”
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T Cell Help Amplifies Innate Signals in CD8+ DCs for Optimal CD8+ T Cell Priming by Greyer, Marie, Whitney, Paul G., Stock, Angus T., Davey, Gayle M., Tebartz, Christina, Bachem, Annabell, Mintern, Justine D., Strugnell, Richard A., Turner, Stephen J., Gebhardt, Thomas, O’Keeffe, Meredith, Heath, William R., Bedoui, Sammy

“…DCs often require stimulation from CD4+ T cells to propagate CD8+ T cell responses, but precisely how T cell help optimizes the priming capacity of DCs and why…”
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Classical Type 1 Dendritic Cells Dominate Priming of Th1 Responses to Herpes Simplex Virus Type 1 Skin Infection by Harpur, Christopher M, Kato, Yu, Dewi, Shinta T, Stankovic, Sanda, Johnson, Darryl N, Bedoui, Sammy, Whitney, Paul G, Lahoud, Mireille H, Caminschi, Irina, Heath, William R, Brooks, Andrew G, Gebhardt, Thomas

“…CD4 T cell responses are crucial for the control of many intracellular pathogens, yet the requirements for their induction are not fully understood. To better…”
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A Sheaf Theoretical Approach to Uncertainty Quantification of Heterogeneous Geolocation Information by Joslyn, Cliff A., Charles, Lauren, DePerno, Chris, Gould, Nicholas, Nowak, Kathleen, Praggastis, Brenda, Purvine, Emilie, Robinson, Michael, Strules, Jennifer, Whitney, Paul

“…Integration of multiple, heterogeneous sensors is a challenging problem across a range of applications. Prominent among these are multi-target tracking, where…”
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Total sleep deprivation reduces top-down regulation of emotion without altering bottom-up affective processing by Stenson, Anthony R, Kurinec, Courtney A, Hinson, John. M, Whitney, Paul, Van Dongen, Hans P. A

“…Sleep loss is reported to influence affective processing, causing changes in overall mood and altering emotion regulation. These aspects of affective…”
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PEGylation of a TLR2-agonist-based vaccine delivery system improves antigen trafficking and the magnitude of ensuing antibody and CD8+ T cell responses by Sekiya, Toshiki, Yamagishi, Junya, Gray, John Henry V, Whitney, Paul G, Martinelli, Axel, Zeng, Weiguang, Wong, Chinn Yi, Sugimoto, Chihiro, Jackson, David C, Chua, Brendon Y

“…Abstract The lipopeptide R4 Pam2 Cys is an agonist for toll-like receptor-2 (TLR2), a key pathogen-associated molecular pattern receptor expressed on many…”
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Correction: Syk Signaling in Dendritic Cells Orchestrates Innate Resistance to Systemic Fungal Infection by Whitney, Paul G, Bär, Eva, Osorio, Fabiola, Rogers, Neil C, Schraml, Barbara U, Deddouche, Safia, LeibundGut-Landmann, Salomé, Reis e Sousa, Caetano

“…[This corrects the article DOI: 10.1371/journal.ppat.1004276.]…”
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Optimal protection against Salmonella infection requires noncirculating memory by Benoun, Joseph M., Peres, Newton G., Wang, Nancy, Pham, Oanh H., Rudisill, Victoria L., Fogassy, Zachary N., Whitney, Paul G., Fernandez-Ruiz, Daniel, Gebhardt, Thomas, Pham, Quynh-Mai, Puddington, Lynn, Bedoui, Sammy, Strugnell, Richard A., McSorley, Stephen J.

“…While CD4 Th1 cells are required for resistance to intramacrophage infections, adoptive transfer of Th1 cells is insufficient to protect against Salmonella…”
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Trait anxiety impairs cognitive flexibility when overcoming a task acquired response and a preexisting bias by Wilson, Cristina G, Nusbaum, Amy T, Whitney, Paul, Hinson, John M

“…Individuals with high trait anxiety tend to be worse at flexibly adapting goal-directed behavior to meet changing demands relative to those with low trait…”
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