Genetic Landscape of a Cell

A genome-scale genetic interaction map was constructed by examining 5.4 million gene-gene pairs for synthetic genetic interactions, generating quantitative genetic interaction profiles for approximately 75% of all genes in the budding yeast, Saccharomyces cerevisiae. A network based on genetic inter...

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Bibliographic Details
Published in:	Science (American Association for the Advancement of Science) Vol. 327; no. 5964; pp. 425 - 431
Main Authors:	Costanzo, Michael, Baryshnikova, Anastasia, Bellay, Jeremy, Kim, Yungil, Spear, Eric D, Sevier, Carolyn S, Ding, Huiming, Koh, Judice L.Y, Toufighi, Kiana, Mostafavi, Sara, Prinz, Jeany, St. Onge, Robert P, VanderSluis, Benjamin, Makhnevych, Taras, Vizeacoumar, Franco J, Alizadeh, Solmaz, Bahr, Sondra, Brost, Renee L, Chen, Yiqun, Cokol, Murat, Deshpande, Raamesh, Li, Zhijian, Lin, Zhen-Yuan, Liang, Wendy, Marback, Michaela, Paw, Jadine, San Luis, Bryan-Joseph, Shuteriqi, Ermira, Tong, Amy Hin Yan, van Dyk, Nydia, Wallace, Iain M, Whitney, Joseph A, Weirauch, Matthew T, Zhong, Guoqing, Zhu, Hongwei, Houry, Walid A, Brudno, Michael, Ragibizadeh, Sasan, Papp, Balázs, Pál, Csaba, Roth, Frederick P, Giaever, Guri, Nislow, Corey, Troyanskaya, Olga G, Bussey, Howard, Bader, Gary D, Gingras, Anne-Claude, Morris, Quaid D, Kim, Philip M, Kaiser, Chris A, Myers, Chad L, Andrews, Brenda J, Boone, Charles
Format:	Journal Article
Language:	English
Published:	Washington, DC American Association for the Advancement of Science 22-01-2010 The American Association for the Advancement of Science
Subjects:	Biological and medical sciences Cellular biology Computational Biology Cytogenetics Drug interactions Evolutionary genetics Fundamental and applied biological sciences. Psychology Gene Duplication Gene Expression Regulation, Fungal Gene interaction Gene Regulatory Networks Genes Genes, Fungal Genetic Fitness Genetic mapping Genetics Genetics of eukaryotes. Biological and molecular evolution Genome, Fungal Genomics Genotype & phenotype Human genetics Medical genetics Metabolic Networks and Pathways Microbial genetics Mutation Protein Interaction Mapping Quantitative genetics Research Article Saccharomyces cerevisiae Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae - physiology Saccharomyces cerevisiae Proteins - genetics Saccharomyces cerevisiae Proteins - metabolism Thallophyta, bryophyta Vegetals and fungi Yeast Ascomycota Fungi Genetic mapping Yeast Gene interaction Saccharomyces cerevisiae
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Summary:	A genome-scale genetic interaction map was constructed by examining 5.4 million gene-gene pairs for synthetic genetic interactions, generating quantitative genetic interaction profiles for approximately 75% of all genes in the budding yeast, Saccharomyces cerevisiae. A network based on genetic interaction profiles reveals a functional map of the cell in which genes of similar biological processes cluster together in coherent subsets, and highly correlated profiles delineate specific pathways to define gene function. The global network identifies functional cross-connections between all bioprocesses, mapping a cellular wiring diagram of pleiotropy. Genetic interaction degree correlated with a number of different gene attributes, which may be informative about genetic network hubs in other organisms. We also demonstrate that extensive and unbiased mapping of the genetic landscape provides a key for interpretation of chemical-genetic interactions and drug target identification.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Article-2 ObjectType-Feature-1
ISSN:	0036-8075 1095-9203
DOI:	10.1126/science.1180823