Search Results - "Whitney, Gena S."

Selective Itk Inhibitors Block T-Cell Activation and Murine Lung Inflammation by Lin, Tai-An, McIntyre, Kim W, Das, Jagabandhu, Liu, Chunjian, O'Day, Kathleen D, Penhallow, Becky, Hung, Chen-Yi, Whitney, Gena S, Shuster, David J, Yang, XiaoXia, Townsend, Robert, Postelnek, Jennifer, Spergel, Steven H, Lin, James, Moquin, Robert V, Furch, Joseph A, Kamath, Amrita V, Zhang, Hongjian, Marathe, Punit H, Perez-Villar, Juan J, Doweyko, Arthur, Killar, Loran, Dodd, John H, Barrish, Joel C, Wityak, John, Kanner, Steven B

“…Nonreceptor protein tyrosine kinases including Lck, ZAP-70, and Itk play essential roles in T-cell receptor (TCR) signaling. Gene knockout studies have…”
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CD5 Negatively Regulates the T-Cell Antigen Receptor Signal Transduction Pathway: Involvement of SH2-Containing Phosphotyrosine Phosphatase SHP-1 by Perez-Villar, Juan J., Whitney, Gena S., Bowen, Michael A., Hewgill, Derek H., Aruffo, Alejandro A., Kanner, Steven B.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Phosphorylation of the Linker for Activation of T-Cells by Itk Promotes Recruitment of Vav by Perez-Villar, Juan J, Whitney, Gena S, Sitnick, Mitchell T, Dunn, Robert J, Venkatesan, Srividhya, O'Day, Kathleen, Schieven, Gary L, Lin, Tai-An, Kanner, Steven B

“…The linker for activation of T-cells (LAT) is a palmitoylated integral membrane adaptor protein that resides in lipid membrane rafts and contains nine…”
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The Membrane-proximal Scavenger Receptor Cysteine-rich Domain of CD6 Contains the Activated Leukocyte Cell Adhesion Molecule Binding Site by Whitney, Gena S., Starling, Gary C., Bowen, Michael A., Modrell, Brett, Siadak, Anthony W., Aruffo, Alejandro

“…Binding studies with a CD6 immunoglobulin fusion protein (CD6 Rg) resulted in the identification and cloning of a CD6 ligand. This ligand was found to be a…”
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Abstract 1281: Exploratory analysis of microRNAs as predictive markers of benefit from cetuximab in metastatic colorectal cancer by Kurland, John F., Horak, Christine E., Whitney, Gena S., Malone, Daniel P., Khambata-Ford, Shirin

“…Abstract Global miRNA expression profiling has become increasingly common in cancer research, and miRNA signatures that are correlated to stage of disease or…”
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Characterization of mouse ALCAM (CD166): the CD6-binding domain is conserved in different homologs and mediates cross-species binding by Bowen, M A, Bajorath, J, D'Egidio, M, Whitney, G S, Palmer, D, Kobarg, J, Starling, G C, Siadak, A W, Aruffo, A

“…Activated leukocyte cell adhesion molecule (ALCAM; CD166) is a member of the immunoglobulin gene superfamily (IgSF) which is expressed by activated leukocytes…”
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Molecular Cloning and Expression of an Additional Epidermal Growth Factor Receptor-Related Gene by Plowman, Gregory D., Whitney, Gena S., Neubauer, Michael G., Green, Janell M., McDonald, Vicki L., Todaro, George J., Shoyab, Mohammed

“…Epidermal growth factor (EGF), transforming growth factor α (TGF-α), and amphiregulin are structurally and functionally related growth regulatory proteins…”
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Structure and chromosomal location of the human CD6 gene: detection of five human CD6 isoforms by Bowen, MA, Whitney, GS, Neubauer, M, Starling, GC, Palmer, D, Zhang, J, Nowak, NJ, Shows, TB, Aruffo, A

“…The CD6 protein has been shown to play important roles in T cell costimulation and adhesion. Recently, variably spliced isoforms of CD6 mRNA have been…”
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Periodic, partial inhibition of IkappaB Kinase beta-mediated signaling yields therapeutic benefit in preclinical models of rheumatoid arthritis by Gillooly, Kathleen M, Pattoli, Mark A, Taylor, Tracy L, Chen, Laishun, Cheng, Lihong, Gregor, Kurt R, Whitney, Gena S, Susulic, Vojkan, Watterson, Scott H, Kempson, James, Pitts, William J, Booth-Lute, Hollie, Yang, Guchen, Davies, Paul, Kukral, Daniel W, Strnad, Joann, McIntyre, Kim W, Darienzo, Celia J, Salter-Cid, Luisa, Yang, Zheng, Wang-Iverson, David B, Burke, James R

“…We have previously shown that inhibitors of IkappaB kinase beta (IKKbeta), including 4(2'-aminoethyl)amino-1,8-dimethylimidazo(1,2-a)quinoxaline (BMS-345541),…”
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Analysis of the tyrosine phosphorylation and calcium fluxing of human CD6 isoforms with different cytoplasmatic domains by Kobarg, J, Whitney, G S, Palmer, D, Aruffo, A, Bowen, M A

“…CD6 is a cell surface glycoprotein that functions both as a co-stimulatory and adhesion receptor on T cells. Recently we have described CD6 isoforms (CD6a, b,…”
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Characterization of mouse CD6 with novel monoclonal antibodies which enhance the allogeneic mixed leukocyte reaction by Starling, G C, Whitney, G S, Siadak, A W, Llewellyn, M B, Bowen, M A, Farr, A G, Aruffo, A A

“…Human CD6 is a cell surface protein expressed by thymocytes, mature T cells, a subset of B cells and certain cells of the brain. On human T cells, CD6 has been…”
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Ligans-specific activation of HER4/p180(erbB4), a fourth member of the epidermal growth factor receptor family by Plowman, Gregory D, Culouscou, Jean-Michel, Whitney, Gena S, Green, Janell M

“…The isolation and recombinant expression of a cDNA clone encoding HER4--the fourth member of the human epidermal growth factor receptor (EGFR) family--are…”
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Ligand-Specific Activation of HER4/p180erbB4, a Fourth Member of the Epidermal Growth Factor Receptor Family by Plowman, Gregory D., Culouscou, Jean-Michel, Whitney, Gena S., Green, Janell M., Carlton, Gary W., Foy, Linda, Neubauer, Michael G., Shoyab, Mohammed

“…This report describes the isolation and recombinant expression of a cDNA clone encoding HER4, the fourth member of the human epidermal growth factor receptor…”
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