Search Results - "Whitney, G. Adam"

Medium-throughput Drug Screening of Patient-derived Organoids from Colorectal Peritoneal Metastases to Direct Personalized Therapy by Narasimhan, Vignesh, Wright, Josephine A, Churchill, Michael, Wang, Tongtong, Rosati, Rachele, Lannagan, Tamsin R M, Vrbanac, Laura, Richardson, Anne B, Kobayashi, Hiroki, Price, Timothy, Tye, Gayle X Y, Marker, Julie, Hewett, Peter J, Flood, Michael P, Pereira, Shalini, Whitney, G Adam, Michael, Michael, Tie, Jeanne, Mukherjee, Siddhartha, Grandori, Carla, Heriot, Alexander G, Worthley, Daniel L, Ramsay, Robert G, Woods, Susan L

“…Patients with colorectal cancer with peritoneal metastases (CRPMs) have limited treatment options and the lowest colorectal cancer survival rates. We aimed to…”
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Thyroxine Increases Collagen Type II Expression and Accumulation in Scaffold-Free Tissue-Engineered Articular Cartilage by Whitney, G Adam, Kean, Thomas J, Fernandes, Russell J, Waldman, Stephen, Tse, M Yat, Pang, Stephen C, Mansour, Joseph M, Dennis, James E

“…Low collagen accumulation in the extracellular matrix is a pressing problem in cartilage tissue engineering, leading to a low collagen-to-glycosaminoglycan…”
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An indicator cell assay for blood-based diagnostics by Danziger, Samuel A, Miller, Leslie R, Singh, Karanbir, Whitney, G Adam, Peskind, Elaine R, Li, Ge, Lipshutz, Robert J, Aitchison, John D, Smith, Jennifer J

“…We have established proof of principle for the Indicator Cell Assay Platform™ (iCAP™), a broadly applicable tool for blood-based diagnostics that uses…”
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Scaffold‐free cartilage subjected to frictional shear stress demonstrates damage by cracking and surface peeling by Whitney, G. Adam, Jayaraman, Karthik, Dennis, James E, Mansour, Joseph M

“…Scaffold‐free engineered cartilage is being explored as a treatment for osteoarthritis. In this study, frictional shear stress was applied to determine the…”
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Imaging mass spectrometry reveals heterogeneity of proliferation and metabolism in atherosclerosis by Guillermier, Christelle, Doherty, Sean P, Whitney, Adam G, Babaev, Vladimir R, Linton, MacRae F, Steinhauser, Matthew L, Brown, Jonathan D

“…Atherosclerotic plaques feature local proliferation of leukocytes and vascular smooth muscle cells (VSMCs) and changes in cellular metabolism. Yet the…”
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Disparate response of articular- and auricular-derived chondrocytes to oxygen tension by Kean, Thomas J, Mera, Hisashi, Whitney, G Adam, MacKay, Danielle L, Awadallah, Amad, Fernandes, Russell J, Dennis, James E

“…To determine the effect of reduced (5%) oxygen tension on chondrogenesis of auricular-derived chondrocytes. Currently, many cell and tissue culture experiments…”
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Investigating a continuous shear strain function for depth-dependent properties of native and tissue engineering cartilage using pixel-size data by Motavalli, Mostafa, Whitney, G.Adam, Dennis, James E., Mansour, Joseph M.

“…A previously developed novel imaging technique for determining the depth dependent properties of cartilage in simple shear is implemented. Shear displacement…”
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Methods for producing scaffold-free engineered cartilage sheets from auricular and articular chondrocyte cell sources and attachment to porous tantalum by Whitney, G Adam, Mera, Hisashi, Weidenbecher, Mark, Awadallah, Amad, Mansour, Joseph M, Dennis, James E

“…Scaffold-free cartilage engineering techniques may provide a simple alternative to traditional methods employing scaffolds. We previously reported auricular…”
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Abstract PS4-01: Clinical and genomic correlation of a CLIA certified organoid based functional test in breast cancer patients by Margossian, Astrid, Richardson, Anne, Pollastro, Madison, Churchill, Michael, Schaub, Franz, Pereira, Shalini, Chatterjee, Payel, Rosati, Rachele, Appleyard, Lauren, Durenberger, Grace, Federation, Alex, Whitney, G. Adam, Swan, Hallie, Ainge, Trevor, Diaz, Robert, Hunter, Natasha, Gamboa, Eric, Kemp, Chris, Gadi, Vijayakrishna, Grandori, Carla

“…Abstract The goal of precision medicine is to match the right drug to the right patient. However, every individual cancer carries a unique and complex mosaic…”
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Abstract 818: Organoid based functional test to predict personalized treatment in cholangiocarcinoma by Margossian, Astrid, Schaub, Franz X., Richardson, Annie, Churchill, Michael, Rosati, Rachele, Dullea, Alexandra, Whitney, G Adam, Swan, Hallie, Diaz, Robert, Appleyard, Lauren, Gadi, Vijaykrishna, Zarrinpar, Ali, Javle, Milind, Kemp, Christopher, Pereira, Shalini, Grandori, Carla

“…Abstract Introduction: It is difficult to find targeted therapies that work across the genetically diverse Cholangiocarcinoma (CCA) patient population; genomic…”
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A cancer organogram test as a guide for oncology treatments in SOLID tumors: An analysis of 628 tests in 419 patients by Margossian, Astrid, Pollastro, Madison, Richardson, Annie, Chatterjee, Payel, Lints, Mia, Peretti, Danielle, Rosati, Rachele, Appleyard, Lauren, Durenberger, Grace, Whitney, G. Adam, Swan, Hallie, Pereira, Shalini, Diehl, Adam, Kemp, Christopher J, Goff, Barbara Ann, Banda, Kalyan, Harris, William Proctor, Swisher, Elizabeth M., Gadi, Vijayakrishna K., Grandori, Carla

“…Abstract only 2602 Background: A CLIA-certified organoid based drug sensitivity assay (a cancer organogram) has been developed for all solid tumors. An…”
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Scaffold-free cartilage subjected to frictional shear stress demonstrates damage by cracking and surface peeling: Frictional shear and damage assessment of scaffold-free engineered cartilage by Whitney, G. Adam, Jayaraman, Karthik, Dennis, James E., Mansour, Joseph M.

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Absence of complement protects against bone loss in a model of postmenopausal osteoporosis by MacKay, Danielle L, Kean, Thomas J, Bernardi, Kristina G, Whitney, G. Adam, Dennis, James E, Lin, Feng

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Characterization of the Frictional-Shear Damage Properties of Scaffold-free Engineered Cartilage and Reduction of Damage Susceptibility by Upregulation of Collagen Content by Whitney, G Adam

“…Cartilage tissue engineers have made great inroads on understanding the factors controlling chondrogenesis, however, the biomechanical properties of tissue…”
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