Search Results - "Whitnall, Mark"

Hematological changes as prognostic indicators of survival: similarities between Gottingen minipigs, humans, and other large animal models by Moroni, Maria, Lombardini, Eric, Salber, Rudolph, Kazemzedeh, Mehdi, Nagy, Vitaly, Olsen, Cara, Whitnall, Mark H

“…The animal efficacy rule addressing development of drugs for selected disease categories has pointed out the need to develop alternative large animal models…”
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The Toll-Like Receptor 5 Agonist Entolimod Mitigates Lethal Acute Radiation Syndrome in Non-Human Primates by Krivokrysenko, Vadim I, Toshkov, Ilia A, Gleiberman, Anatoli S, Krasnov, Peter, Shyshynova, Inna, Bespalov, Ivan, Maitra, Ratan K, Narizhneva, Natalya V, Singh, Vijay K, Whitnall, Mark H, Purmal, Andrei A, Shakhov, Alexander N, Gudkov, Andrei V, Feinstein, Elena

“…There are currently no approved medical radiation countermeasures (MRC) to reduce the lethality of high-dose total body ionizing irradiation expected in…”
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Evaluation of the gamma-H2AX assay for radiation biodosimetry in a swine model by Moroni, Maria, Maeda, Daisuke, Whitnall, Mark H, Bonner, William M, Redon, Christophe E

“…There is a paucity of large animal models to study both the extent and the health risk of ionizing radiation exposure in humans. One promising candidate for…”
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The Gottingen Minipig Is a Model of the Hematopoietic Acute Radiation Syndrome: G-Colony Stimulating Factor Stimulates Hematopoiesis and Enhances Survival From Lethal Total-Body γ-Irradiation by Moroni, Maria, PhD, Ngudiankama, Barbara F., PhD, Christensen, Christine, DVM, Olsen, Cara H., MS, DrPH, Owens, Rossitsa, BS, Lombardini, Eric D., VMD, Holt, Rebecca K., DVM, MPH, Whitnall, Mark H., PhD

“…Purpose We are characterizing the Gottingen minipig as an additional large animal model for advanced drug testing for the acute radiation syndrome (ARS) to…”
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A review of radiation countermeasure work ongoing at the Armed Forces Radiobiology Research Institute by Singh, Vijay K., Ducey, Elizabeth J., Brown, Darren S., Whitnall, Mark H.

“…Purpose: The hazard of exposure to ionizing radiation is a serious public and military health concern that has justified substantial efforts to develop…”
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Identification of granulocyte colony-stimulating factor and interleukin-6 as candidate biomarkers of CBLB502 efficacy as a medical radiation countermeasure by Krivokrysenko, Vadim I, Shakhov, Alexander N, Singh, Vijay K, Bone, Frederick, Kononov, Yevgeniy, Shyshynova, Inna, Cheney, Alec, Maitra, Ratan K, Purmal, Andrei, Whitnall, Mark H, Gudkov, Andrei V, Feinstein, Elena

“…Given an ever-increasing risk of nuclear and radiological emergencies, there is a critical need for development of medical radiation countermeasures (MRCs)…”
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Role of radiation-induced granulocyte colony-stimulating factor in recovery from whole body gamma-irradiation by Singh, Vijay K., Fatanmi, Oluseyi O., Singh, Pankaj K., Whitnall, Mark H.

“…► We demonstrate that G-CSF plays an important role in the recovery from irradiation. ► Irradiation induces G-CSF and other hematopoietic cytokines such as…”
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Bone Marrow Endothelial Cells Influence Function and Phenotype of Hematopoietic Stem and Progenitor Cells after Mixed Neutron/Gamma Radiation by Cary, Lynnette, Noutai, Daniel, Salber, Rudolph, Fadiyimu, Opeyemi, Gross, Arthur, Almeida-Porada, Graca, Kidane, Yared, Whitnall, Mark

“…The bone marrow (BM) microenvironment plays a crucial role in the maintenance and regeneration of hematopoietic stem (HSC) and progenitor cells (HSPC). In…”
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δ-tocotrienol protects mouse and human hematopoietic progenitors from γ-irradiation through extracellular signal-regulated kinase/mammalian target of rapamycin signaling by XIANG HONG LI, DADIN FU, LATIF, Nabil H, MULLANEY, Conor P, NEY, Patrick H, MOG, Steven R, WHITNALL, Mark H, SRINIVASAN, Venkataraman, MANG XIAO

“…Exposure to γ-radiation causes rapid hematopoietic cell apoptosis and bone marrow suppression. However, there are no approved radiation countermeasures for the…”
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Hematopoietic Radiation Syndrome in the Gottingen Minipig by Moroni, Maria, Coolbaugh, Thea V., Lombardini, Eric, Mitchell, Jennifer M., Moccia, Krinon D., Shelton, Larry J., Nagy, Vitaly, Whitnall, Mark H.

“…Additional large animal models for the acute radiation syndrome (ARS) would facilitate countermeasure development. We demonstrate here that Gottingen minipigs…”
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5-AED enhances survival of irradiated mice in a G-CSF-dependent manner, stimulates innate immune cell function, reduces radiation-induced DNA damage and induces genes that modulate cell cycle progression and apoptosis by Grace, Marcy B., Singh, Vijay K., Rhee, Juong G., Jackson, William E., Kao, Tzu-Cheg, Whitnall, Mark H.

“…The steroid androst-5-ene-3ß,17ß-diol (5-androstenediol, 5-AED) elevates circulating granulocytes and platelets in animals and humans, and enhances survival…”
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Efficacy of Radiation Countermeasures Depends on Radiation Quality by Cary, Lynnette H., Ngudiankama, Barbara F., Salber, Rudolph E., Ledney, G. David, Whitnall, Mark H.

“…The detonation of a nuclear weapon or a nuclear accident represent possible events with significant exposure to mixed neutron/γ-radiation fields. Although…”
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Gastrointestinal Acute Radiation Syndrome in Göttingen Minipigs (Sus Scrofa Domestica) by Elliott, Thomas B, Deutz, Nicolaas E, Gulani, Jatinder, Koch, Amory, Olsen, Cara H, Christensen, Christine, Chappell, Mark, Whitnall, Mark H, Moroni, Maria

“…In the absence of supportive care, exposing Göttingen minipigs to γ-radiation doses of less than 2 Gy achieves lethality due to hematopoietic acute radiation…”
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Delta-Tocotrienol Protects Mice from Radiation-Induced Gastrointestinal Injury by Li, Xiang Hong, Ghosh, Sanchita P., Ha, Cam T., Fu, Dadin, Elliott, Thomas B., Bolduc, David L., Villa, Vilmar, Whitnall, Mark H., Landauer, Michael R., Xiao, Mang

“…We recently demonstrated that natural delta-tocotrienol (DT3) significantly enhanced survival in total-body irradiated (TBI) mice, and protected mouse bone…”
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Accelerated hematopoietic syndrome after radiation doses bridging hematopoietic (H-ARS) and gastrointestinal (GI-ARS) acute radiation syndrome: Early hematological changes and systemic inflammatory response syndrome in minipig by Moroni, Maria, Elliott, Thomas B., Deutz, Nicolaas E., Olsen, Cara H., Owens, Rossitsa, Christensen, Christine, Lombardini, Eric D., Whitnall, Mark H.

“…Abstract Purpose: To characterize acute radiation syndrome (ARS) sequelae at doses intermediate between the bone marrow (H-ARS) and full gastrointestinal…”
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Effects of genistein administration on cytokine induction in whole-body gamma irradiated mice by Singh, Vijay K., Grace, Marcy B., Parekh, Vaishali I., Whitnall, Mark H., Landauer, Michael R.

“…The development of an effective pharmacological countermeasure is needed to reduce the morbidity and mortality in military and civilian populations associated…”
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MULTIPLE PARAMETER RADIATION INJURY ASSESSMENT USING A NONHUMAN PRIMATE RADIATION MODEL—BIODOSIMETRY APPLICATIONS by Blakely, William F, Ossetrova, Natalia I, Whitnall, Mark H, Sandgren, David J, Krivokrysenko, Vadim I, Shakhov, Alexander, Feinstein, Elena

“…There are urgent needs to establish capability to rapidly assess radiation injury in mass casualty and population monitoring scenarios. This studyʼs objective…”
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Interactions between Endothelial Cells and T Cells Modulate Responses to Mixed Neutron/Gamma Radiation by Cary, Lynnette H., Noutai, Daniel, Salber, Rudolph E., Williams, Margaret S., Ngudiankama, Barbara F., Whitnall, Mark H.

“…Detonation of an improvised nuclear device near a population center would cause significant casualties from the acute radiation syndrome (ARS) due to exposure…”
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Role of NF-κB in hematopoietic niche function of osteoblasts after radiation injury by Xiao, Mang, Inal, Cynthia E, Parekh, Vaishali I, Li, Xiang Hong, Whitnall, Mark H

“…Objective Hematopoietic tissue is very sensitive to ionizing radiation (IR). In adult mammalian bone marrow, hematopoietic stem and progenitor cells (HSPC)…”
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Vascular Access Port Implantation and Serial Blood Sampling in a Gottingen Minipig (Sus scrofa domestica) Model of Acute Radiation Injury by Moroni, Maria, Coolbaugh, Thea V, Mitchell, Jennifer M, Lombardini, Eric, Moccia, Krinon D, Shelton, Larry J, Nagy, Vitaly, Whitnall, Mark H

“…Threats of nuclear and other radiologic exposures have been increasing, but no countermeasure for acute radiation syndrome has been approved by regulatory…”
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