Search Results - "Whitlon, Donna S."

Statins protect mice from high-decibel noise-induced hearing loss by Dépreux, Frédéric, Czech, Lyubov, Young, Hunter, Richter, Claus-Peter, Zhou, Yingjie, Whitlon, Donna S.

“…No medical interventions for noise induced hearing loss (NIHL) are approved by the Food and Drug Administration (USA). Here, we evaluate statins in CBA/CaJ…”
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Directed Differentiation of Human Embryonic Stem Cells Toward Placode‐Derived Spiral Ganglion‐Like Sensory Neurons by Matsuoka, Akihiro J., Morrissey, Zachery D., Zhang, Chaoying, Homma, Kazuaki, Belmadani, Abdelhak, Miller, Charles A., Chadly, Duncan M., Kobayashi, Shun, Edelbrock, Alexandra N., Tanaka‐Matakatsu, Miho, Whitlon, Donna S., Lyass, Ljuba, McGuire, Tammy L., Stupp, Samuel I., Kessler, John A.

“…The ability to generate spiral ganglion neurons (SGNs) from stem cells is a necessary prerequisite for development of cell‐replacement therapies for…”
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Statins and hearing by Whitlon, Donna S.

“…•Statins inhibit HMG-CoA reductase, the rate limiting step in cholesterol synthesis.•Statins have non-cholesterol related effects on signaling pathways and…”
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Selectivity of neural stimulation in the auditory system: a comparison of optic and electric stimuli by Izzo, Agnella D, Suh, Eul, Pathria, Jyoti, Walsh, Joseph T, Whitlon, Donna S, Richter, Claus-Peter

“…Pulsed, mid-infrared lasers were recently investigated as a method to stimulate neural activity. There are significant benefits of optically stimulating nerves…”
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Drug discovery for hearing loss: Phenotypic screening of chemical compounds on primary cultures of the spiral ganglion by Whitlon, Donna S.

“…In the United States there are, at present, no drugs that are specifically FDA approved to treat hearing loss. Although several clinical trials are ongoing,…”
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Hearing differences in Hartley guinea pig stocks from two breeders by Whitlon, Donna S., Young, Hunter, Barna, Mark, Depreux, Frédéric, Richter, Claus-Peter

“…Across the world, dozens of outbred Hartley guinea pig stocks are used for auditory experiments. The genetic makeup of these different stocks will differ due…”
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Sex Genotyping of Archival Fixed and Immunolabeled Guinea Pig Cochleas by Depreux, Frédéric F., Czech, Lyubov, Whitlon, Donna S.

“…For decades, outbred guinea pigs (GP) have been used as research models. Various past research studies using guinea pigs used measures that, unknown at the…”
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Fluvastatin protects cochleae from damage by high-level noise by Richter, Claus-Peter, Young, Hunter, Richter, Sonja V., Smith-Bronstein, Virginia, Stock, Stuart R., Xiao, Xianghui, Soriano, Carmen, Whitlon, Donna S.

“…Exposure to noise and ototoxic drugs are responsible for much of the debilitating hearing loss experienced by about 350 million people worldwide. Beyond…”
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Novel High Content Screen Detects Compounds That Promote Neurite Regeneration from Cochlear Spiral Ganglion Neurons by Whitlon, Donna S., Grover, Mary, Dunne, Sara F., Richter, Sonja, Luan, Chi-Hao, Richter, Claus-Peter

“…The bipolar spiral ganglion neurons (SGN) carry sound information from cochlear hair cells to the brain. After noise, antibiotic or toxic insult to the…”
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Introduction: spiral ganglion neurons by Whitlon, Donna S

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Targeting of the hair cell proteins cadherin 23, harmonin, myosin XVa, espin, and prestin in an epithelial cell model by Zheng, Lili, Zheng, Jing, Whitlon, Donna S, García-Añoveros, Jaime, Bartles, James R

“…We have developed an advantageous epithelial cell transfection model for examining the targeting, interactions, and mutations of hair cell proteins. When…”
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Espins are multifunctional actin cytoskeletal regulatory proteins in the microvilli of chemosensory and mechanosensory cells by Sekerková, Gabriella, Zheng, Lili, Loomis, Patricia A, Changyaleket, Benjarat, Whitlon, Donna S, Mugnaini, Enrico, Bartles, James R

“…Espins are associated with the parallel actin bundles of hair cell stereocilia and are the target of mutations that cause deafness and vestibular dysfunction…”
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Cochlear development: hair cells don their wigs and get wired by Whitlon, Donna S

“…Hair cells and spiral ganglion neurons form functional pairings in the cochlea that transduce the mechanical energy of sound into signals that are carried to…”
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Cryoembedding and sectioning of cochleas for immunocytochemistry and in situ hybridization by Whitlon, Donna S., Szakaly, Renee, Greiner, Mary A.

“…Current emphasis on biochemical and molecular aspects of cochlear anatomy underscores the necessity for high quality cryostat sections of the inner ear. The…”
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Spiral Ganglion Neurons by WHITLON, Donna S

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Polysialic acid in the cochlea of the developing mouse by Whitlon, Donna S., Zhang, Xueli

“…Polysialic acid (PSA), an unusual molecule covalently attached to the neural cell adhesion molecule, NCAM, has been shown to regulate cell‐to‐cell and…”
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Spontaneous association of glial cells with regrowing neurites in mixed cultures of dissociated spiral ganglia by Whitlon, D.S, Tieu, D, Grover, M, Reilly, B, Coulson, M.T

“…Abstract Evidence from developmental and regeneration studies of the cochlea and other tissues gives reason to hypothesize a role for nonneural cells in the…”
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Culture conditions determine the prevalence of bipolar and monopolar neurons in cultures of dissociated spiral ganglion by Whitlon, D.S, Grover, M, Tristano, J, Williams, T, Coulson, M.T

“…Abstract To gain insight into the mechanisms that control the generation or maintenance of the characteristic bipolar morphology of cochlear spiral ganglion…”
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Tenascin-C in the cochlea of the developing mouse by Whitlon, Donna S., Zhang, Xueli, Kusakabe, Moriaki

“…Tenascin‐C is a glycoprotein of the extracellular matrix that acts in vitro as both a permissive and a nonpermissive substrate for neurite growth. We analyzed,…”
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Conchlear inner hair cells exist transiently in the fetal Bronx waltzer (bv/bv) mouse by Whitlon, Donna S., Gabel, Carol, Zhang, Xueli

“…In the cochlea of the adult Bronx waltzer (bv/bv) mouse, the majority of inner hair cells are missing or deformed. As a result, Bronx waltzer mice are severely…”
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