Search Results - "Whitlock, N Andrew"

Increased intraocular pressure in mice treated with dexamethasone by Whitlock, N Andrew, McKnight, Beth, Corcoran, Katie N, Rodriguez, Lawrence A, Rice, Dennis S

“…Glucocorticoids are potent modulators of the immune system and are useful in treating systemic and ocular diseases, but they can increase intraocular pressure…”
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Novel Class of LIM-Kinase 2 Inhibitors for the Treatment of Ocular Hypertension and Associated Glaucoma by Harrison, Bryce A, Whitlock, N. Andrew, Voronkov, Michael V, Almstead, Zheng Y, Gu, Kun-jian, Mabon, Ross, Gardyan, Michael, Hamman, Brian D, Allen, Jason, Gopinathan, Suma, McKnight, Beth, Crist, Mike, Zhang, Yulian, Liu, Ying, Courtney, Lawrence F, Key, Billie, Zhou, Julia, Patel, Nita, Yates, Phil W, Liu, Qingyun, Wilson, Alan G. E, Kimball, S. David, Crosson, Craig E, Rice, Dennis S, Rawlins, David B

“…The discovery of a pyrrolopyrimidine class of LIM-kinase 2 (LIMK2) inhibitors is reported. These LIMK2 inhibitors show good potency in enzymatic and cellular…”
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Discovery and Development of LX7101, a Dual LIM-Kinase and ROCK Inhibitor for the Treatment of Glaucoma by Harrison, Bryce A, Almstead, Zheng Y, Burgoon, Hugh, Gardyan, Michael, Goodwin, Nicole C, Healy, Jason, Liu, Ying, Mabon, Ross, Marinelli, Brett, Samala, Lakshman, Zhang, Yulian, Stouch, Terry R, Whitlock, N. Andrew, Gopinathan, Suma, McKnight, Beth, Wang, Shuli, Patel, Nita, Wilson, Alan G. E, Hamman, Brian D, Rice, Dennis S, Rawlins, David B

“…The structure of LX7101, a dual LIM-kinase and ROCK inhibitor for the treatment of ocular hypertension and associated glaucoma, is disclosed. Previously…”
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Hsp27 Upregulation by HIF-1 Signaling Offers Protection against Retinal Ischemia in Rats by Whitlock, N. Andrew, Agarwal, Neeraj, Ma, Jian-Xing, Crosson, Craig E

“…Previous work from the authors' laboratory has shown that Hsp27 is specifically upregulated after retinal ischemic preconditioning (IPC), and this upregulation…”
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Decreased intraocular pressure in mice following either pharmacological or genetic inhibition of ROCK by Whitlock, N Andrew, Harrison, Bryce, Mixon, Travis, Yu, Xiang-Qing, Wilson, Alan, Gerhardt, Brenda, Eberhart, Derek E, Abuin, Alejandro, Rice, Dennis S

“…Goals of this study were to determine if pharmacological or genetic inhibition of Rho-associated coiled coil containing protein kinases (known as ROCK1 and…”
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Heat Shock Protein 27 Delays Ca2+-Induced Cell Death in a Caspase-Dependent and -Independent Manner in Rat Retinal Ganglion Cells by Whitlock, N. Andrew, Lindsey, Kristie, Agarwal, Neeraj, Crosson, Craig E, Ma, Jian-Xing

“…Hsp27 is a well-characterized and studied antiapoptotic protein. A recent study reported that Hsp27 is upregulated in the retina after retinal ischemic…”
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Heat Shock Protein 27 Delays Ca 2+ -Induced Cell Death in a Caspase-Dependent and -Independent Manner in Rat Retinal Ganglion Cells by Whitlock, N. Andrew, Lindsey, Kristie, Agarwal, Neeraj, Crosson, Craig E., Ma, Jian-Xing

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