Search Results - "Whitley, Guy St.J."

Decidual natural killer cells regulate vessel stability: implications for impaired spiral artery remodelling by Fraser, Rupsha, Whitley, Guy St.J, Thilaganathan, Baskaran, Cartwright, Judith E

“…Highlights • dNK cells isolated from pregnancies with high or normal uterine artery resistance indices. • Normal-RI dNK cells activate ECs and destabilise…”
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all-trans-Retinoic Acid Increases Nitric Oxide Synthesis by Endothelial Cells: A Role for the Induction of Dimethylarginine Dimethylaminohydrolase by Achan, Vinod, Tran, Cam T.L, Arrigoni, Francesca, Whitley, Guy St.J, Leiper, James M, Vallance, Patrick

“…all-trans-Retinoic acid (atRA) has important effects on the developing and mature cardiovascular system. Nitric oxide (NO) production has been associated with…”
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Regulation of nitric oxide synthesis by dimethylarginine dimethylaminohydrolase by MacAllister, Raymond J., Parry, Heather, Kimoto, Masumi, Ogawa, Tadashi, Russell, Rachel J., Hodson, Harold, Whitley, Guy St.J., Vallance, Patrick

“…1 Dimethylarginine dimethylaminohydrolase (DDAH), an enzyme that metabolizes the endogenous nitric oxide synthase inhibitors NG‐monomethyl‐L‐arginine and NG,…”
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Plasma concentrations of asymmetric dimethylarginine, a natural inhibitor of nitric oxide synthase, in normal pregnancy and preeclampsia by Holden, Desmond P., Fickling, Sara A., Whitley, Guy St.J., Nussey, Stephen S.

“…OBJECTIVE: We investigated the change in the plasma concentration of asymmetric dimethylarginine, an endogenous inhibitor of nitric oxide synthase, in early-,…”
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Nitric oxide inhibits polyamine‐induced apoptosis in the human extravillous trophoblast cell line SGHPL‐4 by Dash, Philip R., Cartwright, Judith E., Whitley, Guy St.J.

“…BACKGROUND: Polyamines are regulators of proliferation and differentiation in mammalian cells. They are also known to regulate cell survival and apoptosis,…”
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S-nitrosylation of proteins at the leading edge of migrating trophoblasts by inducible nitric oxide synthase promotes trophoblast invasion by Harris, Lynda K., McCormick, James, Cartwright, Judith E., Whitley, Guy St.J, Dash, Philip R.

“…Nitric oxide regulates many important cellular processes including motility and invasion. Many of its effects are mediated through the modification of specific…”
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Identification of two human dimethylarginine dimethylaminohydrolases with distinct tissue distributions and homology with microbial arginine deiminases by Leiper, J M, Santa Maria, J, Chubb, A, MacAllister, R J, Charles, I G, Whitley, G S, Vallance, P

“…Methylarginines inhibit nitric oxide synthases (NOS). Cellular concentrations of methylarginines are determined in part by the activity of dimethylarginine…”
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Nitric oxide protects human extravillous trophoblast cells from apoptosis by a cyclic GMP-dependent mechanism and independently of caspase 3 nitrosylation by Dash, Philip R., Cartwright, Judith E., Baker, Philip N., Johnstone, Alan P., Whitley, Guy St.J.

“…Apoptosis is thought to play an important regulatory role in placental development and inappropriate trophoblast apoptosis has been implicated in complications…”
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Trophoblast apoptosis is inhibited by hepatocyte growth factor through the Akt and β-catenin mediated up-regulation of inducible nitric oxide synthase by Dash, Philip R., Whitley, Guy St.J., Ayling, Laura-Jo, Johnstone, Alan P., Cartwright, Judith E.

“…Excessive apoptosis of trophoblast cells is thought to be a contributing factor in complications of pregnancy such as pre-eclampsia. Hepatocyte growth factor…”
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Hepatocyte growth factor-induced endothelial cell motility is mediated by the upregulation of inducible nitric oxide synthase expression by Purdie, Karin J., Whitley, Guy St.J., Johnstone, Alan P., Cartwright, Judith E.

“…Abstract Objectives: Hepatocyte growth factor (HGF) is an angiogenic mitogen which stimulates migration in various cell types and has been shown to induce the…”
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Insulin resistance and endothelial dysfunction in Asian Indian women with polycystic ovary syndrome by Kaushal, Rashmi, Bano, Gul, Rodin, Andrew, Whitley, Guy St.J, Nussey, Stephen S

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The Expression and Release of Adhesion Molecules by Human Endothelial Cell Lines and Their Consequent Binding of Lymphocytes by Cartwright, Judith E., Whitley, Guy St.J., Johnstone, Alan P.

“…We report the characterization of a novel series of human endothelial cell lines (designated SGHEC) regarding the expression and release of adhesion molecules…”
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Angiotensin II-induced inositol phosphate production in isolated rat zona glomerulosa and fasciculata/reticularis cells by Whitley, G S, Hyatt, P J, Tait, J F

“…Angiotensin II (2.5 to 250nM) induced, within 60 sec, a significant increase in [3H]inositol-labeled inositol phosphate, inositol bisphosphate, and inositol…”
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